The role of p21(ras) in pancreatic neoplasia and chronic pancreatitis

Human Pathology

Volumn 30, Issue 6, 1999, Pages 602-610

  Mulligan, Niall J ^b   Yang, Shi ^b   Andry, Chris ^b   Klein, Michael ^b   O'Brien, Michael J ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Carcinoma; Chronic pancreatitis; Intraductal papillary mucinous tumor; K ras; Pancreatic ductal cell

Indexed keywords

PROTEIN P21; RAS PROTEIN; HRAS PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER REGRESSION; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CODON; FEMALE; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TRANSFORMATION; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PANCREAS TUMOR; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; CARCINOMA; CHRONIC DISEASE; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; ONCOGENE RAS; PANCREATITIS; PATHOLOGY;

AGED; CARCINOMA; CHRONIC DISEASE; FEMALE; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; PANCREATITIS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS P21(RAS);

EID: 0032588232     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90082-5     Document Type: Article

References (37)

1. Bos JL: ras oncogenes in human cancer: A review. Cancer Res 49:4682-4689, 1989
2. Almoguera C, Shibata D, Forrester K, et al: Most human carcinomas of the exocrine pancreas contain mutant C-K-ras genes. Cell 53:549-554, 1988
3. Hruban RH, van Mansfeld AD, Offerhaus GJ, et al: K-ras oncogene activation in adenocarcinoma of the human pancreas: A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143:545-554, 1993
4. Dergham ST, Dugan MC, Kueway R, et al: Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma. Int J Pancreatol 21:127-43, 1997
5. Lemoine NR, Jain S, Hughes C, et al: Ki-ras oncogene activation in preinvasive pancreatic cancer. Gastroenterology 102:230-236, 1992
6. Kloppel G, Solcia E, Longnecker DS, et al: Histologic Typing of Tumors of the Exocrine Pancreas. New York, NY, Springer-Verlag; 1996
7. Morohoshi T, Kanda M, Asanuma K, et al: Intraductal papillary neoplasms of the pancreas: A clinicopathologic study of six patients. Cancer 64:1329-1335, 1989
8. Ohhashi K, Murakami Y, Takekoshi T, et al: Four cases of "Mucin producing" cancer of the pancreas on specific findings of the papilla of vater. Prog Dig Endosc 20:348-351, 1982 (Japanese abstract in English)
9. Sessa F, Solcia E, Capella C, et al: Intraductal papillary mucinous tumors represent a distinct group of pancreatic neoplasms: An investigation of tumor cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients. Virchows Arch 425:357-367, 1994
10. Santini D, Campione O, Salerno A, et al: Intraductal papillary-mucinous neoplasm of the pancreas. Arch Pathol Lab Med 119:209-213, 1995
11. Ratcliffe N, Terhune PG, Longnecker DS: Small intraductal papillary-mucinous adenomas of the pancreas. Arch Pathol Lab Med 120:1111-1115, 1996
12. Hoshi T, Imai M, Ogawa K: Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas. J Surg Oncol 55:84-91, 1994
13. Kondo H, Sugano K, Fukayama N, et al: Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas. Cancer 79:900-905, 1997
14. Satoh K, Sawai T, Shimosegawa T, et al: Point mutation of c-k-ras oncogene at codon 12 in mucin-producing cystic tumor of the pancreas. Nippon Shokakibyo Gakkai Zasshi 88:2795-2803, 1991
15. Satoh K, Shimosegawa T, Moriizumi S, et al: K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas. Pancreas 12:362-368, 1996
16. Tada M, Omata M, Ohto M: Ras gene mutations in intraductal papillary neoplasms of the pancreas. Cancer 67:634-637, 1991
17. Yanagisawa A, Kato Y, Ohtake K, et al: c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas. Jpn J Cancer Res 82:1057-1060, 1991
18. Z'graggen K, Rivera JA, Pins M, et al: Intraductal papillary mucinous tumors of the pancreas: The frequency of activating K-ras mutations correlates to the degree of histopathologic abnormality. Ann Surg 226:491-498, 1997
19. Hall A: The cellular functions of small GTP-binding proteins. Science 249:635-640, 1990
20. Kim K, Kuo T, Cai J, et al: N-ras protein: Frequent quantitative and qualitative changes occur in human colorectal carcinomas. Int J Cancer 71:767-775, 1997
21. Ng S, Conlon J, Lavecchio J, et al: Production and characterization of monoclonal antibodies to Ha-ras and N-ras. Hybridoma 10:467-480, 1991
22. Hamer PJ, Trimpe KL, Pullano T, et al: Production and characterization of anti-ras p21 monoclonal antibodies. Hybridoma 9:573-587, 1990
23. Shibata D: Extraction of DNA from paraffin embedded tissue for analysis by polymerase chain reaction: New tricks from old friends. HUM PATHOL 25:561-563, 1994
24. Kahn SM, Jiang W, Culbertson TA, et al: Rapid and sensitive non-radioactive detection of mutant K-ras genes via "enriched" PCR amplification. Oncogene 6:1079-1083, 1991
25. Yanagisawa A, Ohtake K, Ohashi K, et al: Frequent c-Ki-ras oncogene activation in mucus cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res 53:953-956, 1993
26. Rivera JA, Rall CJ, Graeme-Cooke F, et al: Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia. Surgery 121:42-49, 1997
27. Tada M, Ohashi M, Shiratori Y, et al: Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 110:227-231, 1996
28. Tabata T, Fujimori T, Maeda SW, et al: The role of Ras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis. Int J Pancreatol 14:237-244, 1993
29. Furuya N, Kawa S, Akamatsu T, et al: Long term follow up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice. Gastroenterology 113:593-598, 1997
30. Tada M, Omata M, Ohto M: Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma. Gastroenterology 100:233-238, 1991
31. Van Laetham JL, Vertongen P, Deviere J, et al: Detection of c-Ki-ras gene mutations from pancreatic duct brushings in the diagnosis of pancreatic tumors. Gut 36:781-787, 1995
32. Karlson BM, Ekbom A, Josefsson S, et al: The risk of pancreatic cancer following pancreatitis: an association due to confounding? Gastroenterology 113:587-592, 1997
33. Lowenfels AB, Maisonneuve P, Cavallini G, et al: The International Pancreatitis Study group: Pancreatitis and the risk of pancreatic cancer. N Engl J Med 328:1443-1437, 1993
34. Van Laetham V, Bourgeois M, Delhaye J, et al: Ki-ras mutations in patients with chronic pancreatitis: High prevalence but undetermined relevance. Gastroenterology 112:A490, 1997 (abstr)
35. Jen J, Powell SM, Papadopoulos N, et al: Molecular determinants of dysplasia in colorectal lesions. Cancer Res 54:5523-5526, 1994
36. Nucci MR, Robinson CR, Longo P, et al: Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa. HUM PATHOL 28:1396-1407, 1997
37. Shimizu M, Saitoh Y, Itoh H: Immunohistochemical staining of Ha-ras oncogene product in normal, benign and malignant human pancreatic tissues. HUM PATHOL 21:607-612, 1990