An in vivo study of the cortisol-cortisone shuttle in subcutaneous abdominal adipose tissue

Clinical Endocrinology

Volumn 50, Issue 1, 1999, Pages 63-68

  Katz, J R ^a   Mohamed Ali, V ^a   Wood, P J ^b   Yudkin, J S ^a   Coppack, S W ^a  

^a WHITTINGTON HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; CORTISONE; HYDROCORTISONE; ISOENZYME;

ADIPOSE TISSUE BLOOD FLOW; ARTICLE; BODY FAT; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE METABOLISM; HORMONE TRANSPORT; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE RELEASE; MALE; OBESITY; ORGAN DISTRIBUTION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SUBCUTANEOUS FAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADIPOSE TISSUE; ADULT; AGED; BODY COMPOSITION; CORTISONE; FEMALE; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; OBESITY; REGIONAL BLOOD FLOW; STATISTICS, NONPARAMETRIC;

EID: 0033057739     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00598.x     Document Type: Article

References (28)

1. Asmal, A.C., Butterfield, W.J., Collins, K.J. & Few, J.D. (1974) Arteriovenous studies on the uptake and metabolism of cortisol in human forearm. Clinical Science and Molecular Medicine, 47, 345-358.
2. Bjorntorp, P. (1991) Adipose tissue distribution and function. International Journal of Obesity, 15 (Suppl. 2), 67-81.
3. Boulton, K.L., Hudson, D.U., Coppack, S.W. & Frayn, K.N. (1992) Steroid hormone interconversions in human adipose tissue in vivo. Metabolism, 41, 556-559.
4. Bujalska, I.J., Kumar, S. & Stewart, P.M. (1997) Does central obesity reflect 'Cushing's disease of the omentum'? Lancet, 349, 1210-1213.
5. Bulow, J., Jelnes, R. & Astrup, A. (1987) Tissue/blood partition coefficients for xenon in various adipose tissue depots in man. Scandinavian Journal of Clinical Laboratory and Investigations, 47, 1-3.
6. Butler, P.C. & Home, P.D. (1987) The measurement of metabolite exchange across muscle beds. Baillières Clinical Endocrinological Metabolism, 1, 863-878.
7. Coppack, S.W., Evans, R.D., Fisher, R.M., Frayn, K.N., Gibbons, G.F., Humphreys, S.M., Kirk, M.L., Potts, J.L. & Hockaday, T.D.R. (1992) Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism, 41, 264-272.
8. Divertie, G.D., Jensen, M.D. & Miles, J.M. (1991) Stimulation of lipolysis in humans by physiological hypercorlisolemia. Diabetes, 40, 1228-1232.
9. Edwards, C.R., Stewart, P.M., Burt, D., Brett, L., McIntyre, M.A., Sutanto, W.S., De Kloet, E.R. & Monder, C. (1988) Localisation of 11 beta-hydroxysteroid dehydrogenase - tissue specific protector of the mineralocorticoid receptor. Lancet, 2, 986-989.
10. Frayn, K.N., Coppack, S.W., Humphreys, S.M. & Whyte, P.L. (1989) Metabolic characteristics of human adipose tissue in vivo. Clinical Science, 76, 509-516.
11. Hauner, H. & Entenmann, G. (1991) Regional variation of adipose differentiation in cultured stromal-vascular cells from the abdominal and femoral adipose tissue of obese women. International Journal of Obesity, 15, 121-126.
12. Jansson, P.A. & Lonnroth, P. (1995) Comparison of two methods to assess the tissue/blood partition coefficient for xenon in subcutaneous adipose tissue in man. Clinical-Physiology, 15, 47-55.
13. Kopelman, P.G. (1998) The endocrinology of obesity. In: Clinical Endocrinology (ed. A.Grossman), pp. 952-956. Blackwell Science Ltd, Oxford.
14. Marin, P., Darin, N., Amemiya, T., Andersson, B., Jern, S. & Bjorntorp, P. (1992) Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism, 41, 882-886.
15. Moore, A., Aitken, R., Burke, C., Gaskell, S., Groom, G., Holder, G., Selby, C. & Wood, P. (1985) Cortisol assays: guidelines for the provision of a clinical biochemistry service. Annals of Clinical Biochemistry, 22, 435-454.
16. Nielsen, S.L. (1972) Adipose tissue blood flow determined by the washout of locally injected 133 Xenon. Scandinavian Journal of Clinical Laboratory and Investigations, 29, 31-36.
17. Ottosson, M., Vikman Adolfsson, K., Enerback, S., Olivecrona, G. & Bjorntorp, P. (1994) The effects of cortisol on the regulation of lipoprotein lipase activity in human adipose tissue. Journal of Clinical and Endocrinological Metabolism, 79, 820-825.
18. Ottosson, M., Marin, P., Karason, K., Elander, A. & Bjorntorp, P. (1995) Blockade of the glucocorticoid receptor with RU 486: effects in vitro and in vivo on human adipose tissue lipoprotein lipase activity. Obesity Research, 3, 233-240.
19. Samra, J.S., Clark, M.L., Humphreys, S.M., MacDonald, I.A., Matthews, D.R. & Frayn, K.N. (1996) Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue. American Journal of Physiology, 271, E996-E1002.
20. Stewart, P.M. (1996) 11 beta-Hydroxysteroid dehydrogenase: implications for clinical medicine. Clinical Endocrinological Oxford, 44, 493-499.
21. Van Uum, S.H.M., Walker, B.R., Hermus, A.R.W.M., Smits, P., Swinkels, L.M.J.W., Thien, T. & Lenders, J.W M. (1997) Presence of 11-beta hydroxysteroid dehydrogenase activity in the human forearm. Hypertension, 30, 87 (Abstract).
22. Walker, B.R., Connacher, A.A., Webb, D.J. & Edwards, C.R. (1992) Glucocorticoids and blood pressure: a role for the cortisol/cortisone shuttle in the control of vascular tone in man. Clinical Science (Colch), 83, 171-178.
23. Weaver, J.U., Kelly, W.F., Monson, J.P., Taylor, N.F. & Wood, P.J. (1997) 11BHSD-1 and 11BHSD-2 activity in hypopituitary adults; effect of body fat distribution and insulin sensitivity on serum and urine cortisol/cortisone ratio and 11oxo/11OH ratio. Journal of Endocrinology, 152, P276 (Abstract).
24. Weidenfeld, J., Siegel, R.A., Levy, J. & Chowers, I. (1982) In vitro metabolism of cortisol by human abdominal adipose tissue. Journal of Steroid Biochemistry, 17, 357-360.
25. Whitworth, J.A., Stewart, P.M., Burt, D., Atherden, S.M. & Edwards, C.R. (1989) The kidney is the major site of cortisone production in man. Clinical Endocrinological Oxford, 31, 355-361.
26. Wood, P.J., Glenn, C. & Donovan, S.J. (1996) A simple RIA for serum cortisone without preliminary steroid chromatography. Journal of Endocrinology, 148, P319 (Abstract).
27. Wood, P.J., Kilpatrick, K. & Barnard, G. (1997) New direct salivary cortisol and cortisone assays using the 'Delfia' system. Journal of Endocrinology, 155, P71 (Abstract).
28. Yang, K., Khalil, M.W., Strutt, B.J. & Killinger, D.W. (1997) 11 beta-Hydroxysteroid dehydrogenase 1 activity and gene expression in human adipose stromal cells: effect on aromatase activity. Journal of Steriod Biochemistry and Mological Biology, 60, 247-253.