Sequential changes in transforming growth factor (TGF)-β1 concentration in synovial fluid and mRNA expression of TGF-β1 receptors in chondrocytes after immobilization of rabbit knees

Journal of Bone and Mineral Metabolism

Volumn 19, Issue 4, 2001, Pages 228-235

  Okazaki, Ryuji ^a   Sakai, Akinori ^a   Uezono, Yasuhito ^b   Ootsuyama, Akira ^a   Kunugita, Naoki ^c   Nakamura, Toshitaka ^a   Norimura, Toshiyuki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Basic fibroblast growth factor; Immobilization; Receptors; Transforming growth factor 1

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; MESSENGER RNA; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL PROLIFERATION; CONTROLLED STUDY; IMMOBILIZATION; KNEE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SYNOVIAL FLUID;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELL DIVISION; CELLS, CULTURED; CHONDROCYTES; DRUG SYNERGISM; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; IMMOBILIZATION; KNEE JOINT; MALE; RABBITS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, MESSENGER; SYNOVIAL FLUID; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034919458     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007740170025     Document Type: Article

References (42)

1. Joint motion in the absence of normal loading does not maintain normal articular cartilage
2. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix
3. Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose
4. Coordinated regulation of hyaluronan and aggrecan content in the articular cartilage of immobilized and exercised dogs
5. A study of the effects of experimental immobilisation on rabbit articular cartilage
6. Effects of immobilization on the articular cartilage in young rabbits. A quantitative light microscopic stereological study
7. Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage
8. Modulation of rabbit articular chondrocyte (RAC) proliferation by TGF-β isoforms
9. Mechanical and physiochemical determinants of the chondrocyte biosynthetic response
10. Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
11. Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage
12. Effects of transforming growth factor-β1 and interleukin-1α on matrix synthesis in osteoarthritic cartilage of the temporo-mandibular joint in aged mice
13. Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage/pannus junction
14. Early elevation of transforming growth factor-β, decorin, and biglycan mRNA levels during cartilage matrix restoration after mild proteoglycan depletion
15. Fibroblast growth factor is an inhibitor of chondrocyte terminal differentiation
16. Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo
17. Mesenchymal cell chondrogenesis is stimulated by basement membrane matrix and inhibited by age-associated factors
18. Regulation of colony formation of differentiated chondrocytes in soft agar by transforming growth factor-β
19. Effects of transforming growth factor βs and basic fibroblast growth factor on articular chondrocytes obtained from immobilised rabbit knees
20. Up-regulation of transforming growth factor (TGF)-β receptors by TGF-β1 in COLO-357 cells
21. Increased expression of TGF-β receptors by scleroderma fibroblasts: Evidence for contribution of autocrine TGF-β signaling to scleroderma phenotype
22. The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
23. Immunoreactive localization of transforming growth factor-β type II receptor-positive cells in rat tibiae
24. Age- and injury-dependent concentrations of transforming growth factor-β1 and proteoglycan fragments in rabbit knee joint fluid
25. p53ALP1, a potential mediator of p53-dependent apoptosis, and its regulation by ser-46-phosphorylated p53
26. Cloning of a TGF β type I receptor that forms a heteromeric complex with the TGF β type II receptor. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA
27. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
28. Cell-cycle-dependent expression of transforming growth factor β type I receptor correlates with differential proliferative effects of TGFβ1 in articular chondrocytes
29. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA
30. Active and latent forms of transforming growth factor β activity in synovial effusions
31. Rapid induction and clearance of TGFβ1 is an early response to wounding in the mouse embryo
32. Articular chondrocytes produce factors that inhibit maturation of sternal chondrocytes in serumfree agarose cultures: A TGF-β independent process
33. Stimulation of cartilage-matrix proteoglycan synthesis by morphologically transformed chondrocytes grown in the presence of fibroblast growth factor and transforming growth factor-β
34. Transforming growth factor-β and fibroblast growth factor act synergistically to inhibit collagen II synthesis through a mechanism involving regulatory DNA sequences
35. Transforming growth factor-β predominantly stimulates phenotypically changed chondrocytes in osteoarthritic human cartilage
36. Increased synovial expression of transforming growth factor (TGF)-β receptor endoglin and TGF-β1 in rheumatoid arthritis: Possible interactions in the pathogenesis of the disease
37. TGF β signals through a heteromeric protein kinase receptor complex
38. Transforming growth factor-β type-II receptor signalling: Intrinsic/associated casein kinase activity, receptor interactions and functional effects of blocking antibodies
39. TGF-β signalling from cell membrane to nucleus through SMAD proteins
40. Transforming growth factor-β1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways
41. Fibroblast growth factor receptor-1 regulation of Src family kinases
42. Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells