Structural Studies on Flavin Reductase PheA2 Reveal Binding of NAD in an Unusual Folded Conformation and Support Novel Mechanism of Action

Journal of Biological Chemistry

Volumn 279, Issue 13, 2004, Pages 12860-12867

  Van Den Heuvel, Robert H H ^a,b   Westphal, Adrie H ^c   Heck, Albert J R ^b   Walsh, Martin A ^d   Rovida, Stefano ^a   Van Berkel, Willem J H ^c   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UTRECHT UNIVERSITY   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; DIMERS; PHENOLS; SOLVENTS; SUBSTRATES; TOXICITY;

CATABOLISM; RING STACKING; THERMOGLUCOSIDASIUS;

ENZYMES;

FLAVIN REDUCTASE PHEA2; NICOTINAMIDE ADENINE DINUCLEOTIDE; QUERCETIN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; CATALYSIS; CRYSTALLOGRAPHY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MASS SPECTROMETRY; MEDIATOR RELEASE; NANOFLOW ELECTROSPRAY MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING;

AMINO ACID SEQUENCE; BACILLUS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FMN REDUCTASE; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NAD; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

GEOBACILLUS THERMOGLUCOSIDASIUS;

EID: 1842424838     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313765200     Document Type: Article

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