Mutational analysis of basic residues in the N-terminus of the rRNA:m 6A methyltransferase ErmC′

Folia Microbiologica

Volumn 49, Issue 1, 2004, Pages 3-7

  Maravic G ^a   Bujnicki, J M ^b   Flogel M ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 1842418773     PISSN: 00155632     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931637     Document Type: Article

References (12)

1. 6-adenine DNA methylation. In Silico Biol. 1, 175-182 (1999).
2. BUSSIERE D.E., MUCHMORE S.W., DEALWIS C.G., SCHLUCKEBIER G., NIENABER V.L., EDALJI R.P., WALTER K.A., LADROR U.S., HOLZMAN T.F., ABAD-ZAPATERO C.: Crystal structure of ErmC′, an rRNA methyltransferase which mediates antibiotic resistance in bacteria. Biochemistry 37, 7103-7112 (1998).
3. CHENG X., ROBERTS R.J.: AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucl.Acids Res. 29, 3784-3795 (2001).
4. FARROW K.A., LYRAS D., POLEKHINA G., KOUTSIS K., PARKER M.W., ROOD J.I.: Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens. Antimicrob.Agents Chemother. 46, 1253-1261 (2002).
5. FAUMAN E.B., BLUMENTHAL R.M., CHENG X.: Structure and evolution of AdoMet-dependent methyltransferases, pp. 1-38 in X. Cheng, R.M. Blumenthal (Eds): S-Adenosylmethionine Dependent Methyltransferases: Structures and Function. World Scientific, Singapore 1999.
6. MONOD M., DENOYA C., DUBNAU D.: Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis. J.Bacteriol. 167, 138-147 (1986).
7. SCHLUCKEBIER G., ZHONG P., STEWART K.D., KAVANAUGH T.J., ABAD-ZAPATERO C.: The 2.2Å structure of the rRNA methyltransferase ErmC′ and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. J.Mol.Biol. 289, 277-291 (1999).
8. SCHLUNZEN F., ZARIVACH R., HARMS J., BASHAN A., TOCILJ A., ALBRECHT R., YONATH A., FRANCESCHI F.: Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413, 814-821 (2001).
9. SU S. L., DUBNAU D.: Binding of Bacillus subtilis ErmC′ methyltransferase to 23S rRNA. Biochemistry 29, 6033-6042 (1990).
10. WEISBLUM B.: Erythromycin resistance by ribosome modification. Antimicrob.Agents Chemother. 39, 577-585 (1995).
11. YU L.A., PETROS M., SCHNUCHEL A., ZHONG P., SEVERIN J.M., WALTER K., HOLZMAN T.F., FESIK S.W.: Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. Nature Struct. Biol. 4, 483-489 (1997).
12. ZHONG P., PRATT S.D., EDALJI R.P., WALTER K.A., HOLZMAN T.F., SHIVAKUMAR A.G., KATZ L.: Substrate requirements for ErmC′ methyltransferase activity. J.Bacteriol. 177, 4327-4332 (1995).