Responses of guinea pig pups during isolation in a novel environment may represent stress-induced sickness behaviors

Physiology and Behavior

Volumn 81, Issue 1, 2004, Pages 5-13

  Hennessy, Michael B ^a   Deak, Terrence ^b   Schiml Webb, Patricia A ^a   Wilson, Shannon E ^a   Greenlee, Tess M ^a   McCall, Elizabeth ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b BINGHAMTON UNIVERSITY   (United States)

Author keywords

Acute phase response; Body temperature; Cytokines; Guinea pig; Interleukin 1; Isolation; Maternal separation; Sickness behaviors

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE;

ACUTE PHASE RESPONSE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EYELID CLOSURE; FEMALE; GUINEA PIG; ILLNESS BEHAVIOR; LOCOMOTION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RECTUM TEMPERATURE; REFLEX; SOCIAL ISOLATION; STIMULUS RESPONSE; STRESS; VOCALIZATION;

EID: 1842418505     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2003.11.008     Document Type: Article

References (45)

1. Aubert A. Sickness and behaviour in animals: a motivational perspective. Neurosci. Biobehav. Rev. 23:1999;1029-1036.
2. Baumann H., Gauldie J. The acute phase response. Immunol. Today. 15:1994;74-80.
3. Berryman J.C. Guinea-pig vocalizations: their structure, causation and function. Zeit Tierpsychol. 41:1976;80-106.
4. Bowlby J. Attachment and loss. Attachment. vol. 1:1969;Basic Books, New York.
5. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Coe C.L. Psychosocial factors and immunity in nonhuman primates: a review. Psychosom. Med. 55:1993;298-308.
7. Coe C.L., Rosenberg L.T., Levine S. Prolonged effect of psychological disturbance on macrophage chemiluminescence in the squirrel monkey. Brain. Behav. Immun. 2:1988;151-160.
8. Connor T.J., Leonard B.E. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci. 62:1998;583-606.
9. Dantzer R., Bluthe R.M., Kent S., Goodall G. Behavioral effects of cytokines: an insight into mechanisms of sickness behavior. DeSouza E.B. Methods in neuroscience. Neurobiology of Cytokines Part B. vol. 17:1993;130-150 Academic Press, San Diego (CA).
10. Dantzer R, Wollman EE, Yirmiya R, editors. Cytokines, stress, and depression. New York: Kluwer Academic/Plenum, 1999.
11. Deak T., Bellamy C., D'Agnotino L.G. Exposure to forced swim test does not alter central production of IL-1. Brain Res. 972:2003;53-63.
12. Deak T., Meriwether J.L., Fleshner M., Spencer R.L., Abouhamze A., Moldawer L.L.et al. Evidence that brief stress may induce the acute phase response in rats. Am. J. Physiol. 273:1997;R1998-R2004.
13. Deak T., Nguyen K.T., Cotter C.S., Fleshner M., Watkins L.R., Maier S.F.et al. Long term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor. Brain Res. 847:1999;211-220.
14. Gibertini M., Newton C., Friedman H., Klein T.W. Spatial learning impairment in mice infected with Legionella pneumophila or administered exogenous interleukin-1-beta. Brain Behav. Immun. 9:1995;113-128.
15. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 12:1988;123-137.
16. Hennessy M.B., Deak T., Schiml-Webb P.A. Stress-induced sickness behaviors: an alternative hypothesis for responses during maternal separation. Dev. Psychobiol. 39:2001;76-83.
17. Hennessy M.B., Moorman L. Factors influencing cortisol and behavioral responses to maternal separation in guinea pigs. Behav. Neurosci. 103:1989;378-385.
18. Hennessy M.B., Long S.J., Nigh C.L., Williams M.T., Nolan D.J. Effects of peripherally administered corticotropin-releasing factor (CRF) and a CRF antagonist: does peripheral CRF activity mediate behavior of guinea pig pups during isolation? Behav. Neurosci. 109:1995;1137-1145.
19. Hosoi T., Okuma Y., Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1β expression in the brain and activates the HPA axis. Am. J. Physiol. 279:2000;R141-R147.
20. Katz R.J. Animal models and human depressive disorders. Neurosci. Biobehav. Rev. 5:1981;231-246.
21. Kaufman I.C., Rosenblum L.A. The reaction to separation in infant monkeys: anaclitic depression and conservation withdrawal. Psychosom. Med. 29:1967;648-675.
22. Kronfol Z., Remick D.G. Cytokines and the brain: implications for clinical psychiatry. Am. J. Psychiatr. 157:2000;683-694.
23. LeMay L.G., Vander A.J., Kluger M.J. The effects of psychological stress on plasma interleukin-6 activity in rats. Physiol. Behav. 47:1990;957-961.
24. Leu S.J., Singh L.K. Stimulation of interleukin-6 production by corticotropin-releasing hormone. Cell Immunol. 143:1992;220-227.
25. Licinio J., Wong M.L. The role of inflammatory mediators in the biology of major depression: central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection. Mol. Psychiatry. 4:1999;317-327.
26. Laudenslager M.L., Reite R., Harbeck R.J. Suppressed immune response in infant monkeys associated with maternal separation. Behav. Neural Biol. 36:1982;40-48.
27. Lubach G.R., Coe C.L., Karaszewski J.W., Ershler W.B. Effector and target cells in the assessment of natural cytotoxic activity of rhesus monkeys. Am. J. Primatol. 39:1996;275-287.
28. Maes M. A review on the acute phase response in major depression. Rev. Neurosci. 4:1993;407-416.
29. Maier S.F., Watkins L.R. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape responding produced by inescapable shock. Brain Res. 695:1995;279-282.
30. Maier S.F., Watkins L.R. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol. Rev. 105:1998;83-107.
31. McInturf S.M., Hennessy M.B. Peripheral administration of a corticotropin-releasing factor antagonist increases the vocalizing and locomotor activity of isolated guinea pig pups. Physiol. Behav. 60:1996;707-710.
32. Milligan E.D., Nguyen K.T., Deak T., Hinde J.L., Fleshner M., Watkins L.R.et al. The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone. Brain Res. 810:1998;48-58.
33. Mineka S., Suomi S.J. Social separation in monkeys. Psychol. Bull. 85:1978;1376-1400.
34. Nguyen K.T., Deak T., Owens S.M., Kohno T., Fleshner M., Watkins L.R.et al. Exposure to acute stress induces brain interleukin-1β protein in the rat. J. Neurosci. 18:1998;2239-2246.
35. Nguyen K.T., Deak T., Will M.J., Hansen M.K., Hunsaker B.N., Fleshner M.et al. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress. Brain Res. 859:2000;193-201.
36. Oka T., Oka K., Hori T. Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosom. Med. 63:2001;476-486.
37. Paez Pereda M., Sauer J., Perez Castro C., Finkielman S., Stalla G.K., Holsboer F.et al. Corticotropin-releasing hormone differentially modulates the interleukin-1 system according to the level of monocyte activation by endotoxin. Endocrinology. 136:1995;5504-5510.
38. Pettijohn T.F. Attachment and separation distress in the infant guinea pig. Dev. Psychobiol. 12:1979;73-81.
39. Pugh C.R., Nguyen K.T., Gonyea J.L., Fleshner M., Watkins L.R., Maier S.F.et al. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by isolation. Behav. Brain Res. 106:1999;109-118.
40. Romanovsky A.A., Kulchitsky V.A., Akulich N.V., Koulchitsky S.V., Simons C.T., Sessler D.I.et al. First and second phases of biphasic fever: two sequential stages of the sickness syndrome? Am. J. Physiol. 271:1996;R244-R253.
41. Rosenblum L.A., Plimpton E.H. The infant's effort to cope with separation. Lewis R., Rosenblum L. The uncommon child. 1981;225-257 Plenum, New York.
42. Singh L.K., Leu S.J. Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2. Neurosci. Lett. 120:1990;151-154.
43. Soszynski D. Inhibition of nitric oxide synthase delays the development of tolerance to LPS in rats. Physiol. Behav. 76:2002;159-169.
44. Webster E.L., Torpy D.J., Elenkov I.J., Chrousos G.P. Corticotropin-releasing hormone and inflammation. Ann. N. Y. Acad. Sci. 840:1998;21-32.
45. Zhou D., Kusnecov A.W., Shurin M.R., DePaoli M., Rabin B.S. Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology. 133:1993;2523-2530.