Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56Lck

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 10, 2002, Pages 1361-1364

  Chen, Ping ^a   Norris, Derek ^a   Iwanowicz, Edwin J ^a   Spergel, Steven H ^a   Lin, James ^a   Gu, Henry H ^a   Shen, Zhongqi ^a   Wityak, John ^a   Lin, Tai An ^a   Pang, Suhong ^a   De Fex, Henry F ^a   Pitt, Sidney ^a   Shen, Ding Ren ^a   Doweyko, Arthur M ^a   Bassolino, Donna A ^a   Roberge, Jacques Y ^a   Poss, Michael A ^a   Chen, Bang Chi ^a   Schieven, Gary L ^a   Barrish, Joel C ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 IMIDAZOQUINOXALINE; PROTEIN TYROSINE KINASE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; IC 50; LYMPHOCYTE PROLIFERATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; IMIDAZOLES; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUINOXALINES; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 18344373265     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00191-9     Document Type: Article

References (30)