The vasorelaxing effect of CGRP and natriuretic peptides in isolated bovine retinal arteries

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 4, 2005, Pages 1420-1427

  Boussery, Koen ^a   Delaey, Christophe ^a   Van De Voorde, Johan ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 4 AMINOPYRIDINE; ACETYLCHOLINE; ADRENOMEDULLIN; ADRENOMEDULLIN[22-52]; APAMIN; ATRIAL NATRIURETIC FACTOR; BARIUM CHLORIDE; BRAIN NATRIURETIC PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHARYBDOTOXIN; GLIBENCLAMIDE; GUANYLATE CYCLASE INHIBITOR; IBERIOTOXIN; INDOMETACIN; LEMAKALIM; N(G) NITROARGININE; NATRIURETIC FACTOR; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE INHIBITOR; TETRYLAMMONIUM CHLORIDE; UNCLASSIFIED DRUG; 1H (1,2,4)OXADIAZOLO(4,3 A)QUINOXALIN 1 ONE; 1H-(1,2,4)OXADIAZOLO(4,3-A)QUINOXALIN-1-ONE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE (8 37); CALCITONIN GENE-RELATED PEPTIDE (8-37); ENZYME INHIBITOR; OXADIAZOLE DERIVATIVE; PEPTIDE FRAGMENT; POTASSIUM CHANNEL; QUINOXALINE DERIVATIVE;

ANIMAL CELL; ARTERY CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; DRUG EFFECT; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; RETINA ARTERY; STEADY STATE; VASCULAR ENDOTHELIUM; VASODILATATION; ANIMAL; BLOOD FLOW; CATTLE; DOSE RESPONSE; DRUG ANTAGONISM; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NATRIURETIC PEPTIDES; NITROARGININE; OXADIAZOLES; PEPTIDE FRAGMENTS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; QUINOXALINES; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; REGIONAL BLOOD FLOW; RETINAL ARTERY; VASODILATION;

EID: 18244396624     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-1093     Document Type: Article

References (48)

1. Delaey C, Van de Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 2000;32:249-256.
2. Donati G, Pournaras CJ, Munoz JL, et al. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci. 1995;36:2228-2237.
3. Pournaras C, Tsacopoulos M, Chapuis P. Studies on the role of prostaglandins in the regulation of retinal blood flow. Exp Eye Res. 1978;26:687-697.
4. Brazitikos PD, Pournaras CJ, Munoz JL, Tsacopoulos M. Microinjection of L-lactate in the preretinal vitreous induces segmental vasodilation in the inner retina of miniature pigs. Invest Ophthalmol Vis Sci. 1993;34:1744-1752.
5. Delaey C, Van de Voorde J. Retinal arterial tone is controlled by a retinal-derived relaxing factor. Circ Res. 1998;83:714-720.
6. Kaley G. Novel vasodilator released by retinal tissue. Circ Res. 1998;83:772-773.
7. Boussery K, Delaey C, Van de Voorde J. Rat retinal tissue releases a vasorelaxing factor. Invest Ophthalmol Vis Sci. 2002;43:3279-3286.
8. Boussery K, Franki AS, Delaey C, Van de Voorde J. A vasorelaxing factor is released from mouse retinal tissue. Ophthalmic Res. 2002;34:172-177.
9. Delaey C, Boussery K, Van de Voorde J. A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries. Invest Ophthalmol Vis Sci. 2000;41:3555-3560.
10. Ye XD, Laties AM, Stone RA. Peptidergic innervation of the retinal vasculature and optic nerve head. Invest Ophthalmol Vis Sci. 1990;31:1731-1737.
11. Prieto D, Benedito S, Nielsen PJ, Nyborg NC. Calcitonin generelated peptide is a potent vasodilator of bovine retinal arteries in vitro. Exp Eye Res. 1991;53:399-405.
12. Gaspar MN, Ribeiro CA, Cunha-Vaz JG, Macedo TR. Effects of neuropeptides on the sumatriptan-disturbed circulation in the optic nerve head of rabbits. Pharmacology. 2004;70:152-159.
13. Rollin R, Mediero A, Roldan-Pallares M, Fernandez-Cruz A, Fernandez-Durango R. Natriuretic peptide system in the human retina. Mol Vis. 2004;10:15-22.
14. Barton M, Beny JL, d'Uscio LV, Wyss T, Noll G, Luscher TF. Endothelium-independent relaxation and hyperpolarization to C-type natriuretic peptide in porcine coronary arteries. J Cardiovasc Pharmacol. 1998;31:377-383.
15. Mitani Y, Maruyama J, Yokochi A, et al. Modulated vasodilator responses to natriuretic peptides in rats exposed to chronic hypoxia. Eur Respir J. 2000;15:400-406.
16. Mori Y, Takayasu M, Suzuki Y, Shibuya M, Yoshida J, Hidaka H. Vasodilator effects of C-type natriuretic peptide on cerebral arterioles in rats. Eur J Pharmacol. 1997;320:183-186.
17. Seguchi H, Nishimura J, Toyofuku K, Kobayashi S, Kumazawa J, Kanaide H. The mechanism of relaxation induced by atrial natriuretic peptide in the porcine renal artery. Br J Pharmacol. 1996; 118:343-351.
18. Zellner C, Protter AA, Ko E, et al. Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries. Am J Physiol. 1999;276:H1049-H1057.
19. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res. 1977;41:19-26.
20. Nyborg NC, Korsgaard N, Nielsen PJ. Active wall tension: length curve and morphology of isolated bovine retinal small arteries-important feature for pharmacodynamic studies. Exp Eye Res. 1990;51:217-224.
21. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 1995;48:184-188.
22. Hwang TL, Wu CC, Teng CM. Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea. Br J Pharmacol. 1998;125:1158-1163.
23. Mazzuco TL, Dias MA, Calixto JB. Characterization of the mechanism involved in the relaxant response of dopexamine in the guinea pig pulmonary artery in vitro. J Cardiovasc Pharmacol. 1999;33:86-92.
24. Mitamura M, Boussery K, Horie S, Murayama T, Van de Voorde J. Vasorelaxing effect of mesaconitine, an alkaloid from Aconitum japonicum, on rat small gastric artery: possible involvement of endothelium-derived hyperpolarizing factor. Jpn J Pharmacol. 2002;89:380-387.
25. Sheykhzade M, Berg Nyborg NC. Mechanism of CGRP-induced relaxation in rat intramural coronary arteries. Br J Pharmacol. 2001;132:1235-1246.
26. De Clerck I, Boussery K, Pannier JL, Van de Voorde J. Potassium potently relaxes small rat skeletal muscle arteries. Med Sci Sports Exerc. 2003;35:2005-2012.
27. Gao YJ, Hirota S, Zhang DW, Janssen LJ, Lee RM. Mechanisms of hydrogen-peroxide-induced biphasic response in rat mesenteric artery. Br J Pharmacol. 2003;138:1085-1092.
28. Boussery K, Delaey C, Van de Voorde J. Influence of adrenomedulin on tone of isolated bovine retinal arteries. Invest Ophthalmol Vis Sci. 2004;45:552-559.
29. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev. 2004;84:903-934.
30. Yoshimoto R, Mitsui-Saito M, Ozaki H, Karaki H. Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery. Br J Pharmacol. 1998;123:1645-1654.
31. Wisskirchen FM, Burt RP, Marshall I. Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br J Pharmacol. 1998;123:1673-1683.
32. Benedito S, Prieto D, Nielsen PJ, Nyborg NCB. Role of the endothelium in acetylcholine-induced relaxation and spontaneous tone of bovine isolated retinal small arteries. Exp Eye Res. 1991;52:575-579.
33. Brown SM, Jampol LM. New concepts of regulation of retinal vessel tone. Arch Ophthalmol. 1996;114:199-204.
34. Edwards G, Weston AH. EDHF: are there gaps in the pathway? J Physiol. 2001;531:299.
35. Zygmunt PM, Hogestatt ED. Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br J Pharmacol. 1996;117:1600-1606.
36. Magnon M, Calderone V, Floch A, Cavero I. Influence of depolarization on vasorelaxant potency and efficacy of Ca2+ entry blockers, K+ channel openers, nitrate derivatives, salbutamol and paverine in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol. 1998;358:452-463.
37. Callera GE, Yogi A, Tostes RC, Rossoni LV, Bendhack LM. Ca2+-activated K+ channels underlying the impaired acetylcholine-induced vasodilation in 2K-1C hypertensive rats. J Pharmacol Exp Ther. 2004;309:1036-1042.
38. Cortes SF, Rezende BA, Corriu C, et al. Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries. Br J Pharmacol. 2001;133:849-858.
39. Jackson WF. Ion channels and vascular tone. Hypertension. 2000; 35:173-178.
40. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol. 1995; 268:C799-C822.
41. Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev. 1997;77:1165-1232.
42. Nelson MT, Huang Y, Brayden JE, Hescheler J, Standen NB. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature. 1990;344:770-773.
43. Nelson SH, Suresh MS, Dehring DJ, Johnson RL. Relaxation by calcitonin gene-related peptide may involve activation of K+ channels in the human uterine artery. Eur J Pharmacol. 1993;242:255-261.
44. Wisskirchen FM, Gray DW, Marshall I. Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37). Br J Pharmacol. 1999;128:283-292.
45. Champion HC, Santiago JA, Murphy WA, Coy DH, Kadowitz PJ. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997;272: R234-R242.
46. Hasbak P, Sams A, Schifter S, Longmore J, Edvinsson L. CGRP receptors mediating CGRP-, adrenomedullin- and amylin-induced relaxation in porcine coronary arteries: characterization with "Compound 1" (WO98/11128), a non-peptide antagonist. Br J Pharmacol. 2001;133:1405-1413.
47. Hinson JP, Kapas S, Smith DM. Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev. 2000;21:138-167.
48. Poyner DR, Sexton PM, Marshall I, et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev. 2002;54:233-246.