Mechanism of CGRP-induced relaxation in rat intramural coronary arteries

British Journal of Pharmacology

Volumn 132, Issue 6, 2001, Pages 1235-1246

  Sheykhzade, Majid ^a   Berg Nyborg, Niels C ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Calcitonin gene related peptide receptor; Coronary artery; FURA 2

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 (THIENO[3,2 C]PYRIDIN 3 YL) 3 PYRIDINECARBOXYLIC ACID 1 PHENYLETHYL ESTER; 1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCITONIN GENE RELATED PEPTIDE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CORONARY ARTERY BLOOD FLOW; CORONARY VASCULAR RESISTANCE; DRUG EFFECT; DRUG MECHANISM; HYPOXIA; MUSCLE TONE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 0035083862     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703936     Document Type: Article

References (57)

1. Front-surface fluorometry with Fura-2 and effects of nitroglycerin on cytosolic calcium concentrations and on tension in the coronary artery of the pig
2. Phosphorylation of smooth muscle myosin light chain kinase by the catalytic subunit of adenosine 3′:5′-monophosphate-dependent protein kinase
3. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
4. + channels in smooth muscle cells
5. Calcitonin gene-related peptide in the cardiovascular system: Characterization of receptor populations and their (patho)physiological significance
6. + channels by protein kinase C in urinary bladder smooth muscle
7. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels
8. Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance Pimmunoreactive sensory neurons in animals and man: Distribution and release by capsaicin
9. Capsazepine-sensitive release of calcitonin gene-related peptide from C-fibre afferents in guinea-pig heart by low pH and lactic acid
10. Calcitonin gene-related peptide (CGRP) and capsaicin-induced stimulation of heart contractile rate and force
11. Differential release of calcitonin gene-related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain
12. The effects of calcitonin gene-related peptide on the cytosolic calcium concentration and force in the porcine coronary artery
13. Human α-calcitonin gene-related peptide (CGRP) relaxes pig coronary artery in an endothelium-independent manner and elevates cyclic AMP levels
14. 2+ indicators with greatly improved fluorescence properties
15. + channels in rabbit coronary myocytes
16. Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein
17. Phosphorylation of myosin light chain kinase from vascular smooth muscle by cAMP- and cGMP-dependent protein kinases
18. Effects of diltiazem on calcium concentrations in the cytosol and on force of contractions in porcine coronary arterial strips
19. Pharmacological coupling and functional role for CGRP receptors in the vasodilation of rat pial arterioles
20. 2+ level in vascular smooth muscle
21. Mechanisms of relaxation induced by activation of β-adrenoceptors in smooth muscle cells of the guinea-pig enteric artery
22. i and force in rat resistance arteries
23. Calcitonin gene-related peptide relaxes porcine coronary arteries via cyclic AMP-dependent mechanism but not activation of ATP-sensitive potassium channels
24. Release and effects of calcitonin gene-related peptide in myocardial ischaemia
25. The function of myosin and myosin light chain phosphorylation in smooth muscle
26. The mechanisms of the relaxation induced by vasoactive intestinal peptide in the porcine coronary artery
27. Inhibition of smooth muscle tension by cyclic AMP-dependent protein kinase
28. 2+ uptake increase of sarcoplasmic reticulum fraction of hog biliary muscles relaxed by cholecystikinin-C terminal peptides
29. + channels in CGRP-induced dilatation of basilar artery in vivo
30. + channels mediate vasodilatation produced by calcitonin gene-related peptide in human internal mammary but not gastroepiploic arteries
31. + channels of cultured porcine coronary artery smooth muscle cells
32. + channels by angiotensin II and endothelin-1
33. + channels of vascular smooth muscle cells via adenylate cyclase
34. An increased calcium sensitivity of mesenteric resistance vessels in young and adult spontaneously hypertensive rats
35. + channels
36. Direct regulation of smooth muscle contractile elements by second messengers
37. 2-receptor affinity and decreased receptor reserve in rat isolated coronary arteries
38. Active, passive and myogenic characteristics of isolated rat intramural coronary resistance arteries
39. Characterization of β-adrenoceptors subtype in isolated ring preparations of intramural rat coronary small arteries
40. Heterogeneous involvement of endothelium in calcitonin gene-related peptide-induced relaxation in coronary arteries from rat
41. + currents in rabbit arterial smooth muscle via protein kinase A
42. 2+ pump of bovine pulmonary artery
43. Assessment of Fura-2 for measurements of cytosolic free calcium
44. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural rat coronary arteries from male and female Sprague Dawley rats
45. Vasodilating effects of human and rat calcitonin gene-related peptides in isolated porcine coronary arteries
46. + channels in freshly disassociated smooth muscle cells
47. Signal transduction and regulation in smooth muscle
48. Pharmacomechanical coupling: The role of calcium, G-proteins, kinases and phosphatases
49. Cyclic adenosine monophosohate: Potassium-dependent action on vascular smooth muscle membrane potential
50. + channel modulation in arterial smooth muscle
51. 2+-ATPase
52. Effects of isoprenaline on cytosolic calcium concentrations and on tension in the porcine coronary artery
53. Myosin light chain kinase phosphorylation in nitrovasodilator induced swine carotid artery relaxation
54. + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle
55. Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery
56. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate
57. Effects of adrenomedullin and calcitonin gene-related peptide-induced relaxation on contractions of the rat aorta and porcine coronary artery