Inhibitory effect of aureobasidin A on Toxoplasma gondii

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 5, 2005, Pages 1794-1801

  Sonda, Sabrina ^a,b   Sala, Giusy ^d   Ghidoni, Riccardo ^d   Hemphill, Andrew ^c   Pieters, Jean ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d SAN PAOLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUREOBASIDIN A; ENZYME INHIBITOR; SPHINGOLIPID;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BIRTH DEFECT; CELL METABOLISM; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SYNTHESIS; HOST CELL; HUMAN; HUMAN CELL; NONHUMAN; PARASITE IDENTIFICATION; PRIORITY JOURNAL; TOXOPLASMA GONDII;

ANIMALS; ANTIBIOTICS, ANTIFUNGAL; CHROMATOGRAPHY, THIN LAYER; DEPSIPEPTIDES; FLUORESCENT ANTIBODY TECHNIQUE; INDICATORS AND REAGENTS; LIPID METABOLISM; MICROSCOPY, ELECTRON, TRANSMISSION; SPHINGOLIPIDS; TOXOPLASMA;

EID: 18244367101     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.5.1794-1801.2005     Document Type: Article

References (40)

1. Aspinall, T. V., D. H. Joynson, E. Guy, J. E. Hyde, and P. F. Sims. 2002. The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. J. Infect. Dis. 185: 1637-1643.
2. Azzouz, N., B, Rauscher, P. Gerold, M. F. Cesbron-Delauw, J. F. Dubremetz, and R. T. Schwarz. 2002. Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii. Int. J. Parasitol. 32:677-684.
3. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Med. Sci. 37:911-917.
4. Bohne, W., J. Heesemann, and U. Gross. 1994. Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion. Infect. Immun. 62:1761-1767.
5. Campbell, S. A., T. A. Richards, E. J. Mui, B. U. Samuel, J. R. Coggins, R. McLeod, and C. W. Roberts. 2004. A complete shikimate pathway in Toxoplasma gondii: an ancient eukaryotic innovation. Int. J. Parasitol. 34:5-13.
6. Carruthers, V. B. 2002. Host cell invasion by the opportunistic pathogen Toxoplasma gondii. Acta Trop. 81:111-122.
7. Cheng, J., T. S. Park, A. S. Fischl, and X. S. Ye. 2001. Cell cycle progression and cell polarity require sphingolipid biosynthesis in Aspergillus nidulans. Mol. Cell. Biol. 21:6198-6209.
8. Dannemann, B. R., D. M. Israelski, G. S. Leoung, T. McGraw, J. Mills, and J. S. Remington. 1991. Toxoplasma serology, parasitemia and antigenemia in patients at risk for toxoplasmic encephalitis. AIDS 5:1363-1365.
9. Denny, P. W., D. Goulding, M. A. Ferguson, and D. F. Smith. 2004. Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Mol. Microbiol. 52:313-327.
10. Dubey, J. P. 1998. Advances in the life cycle of Toxoplasma gondii. Int. J. Parasitol. 28:1019-1024.
11. Endo, M., K. Takesako, I. Kato, and H. Yamaguchi. 1997. Fungicidal action of aureobasidin A, a cyclic depsipeptide antifungal antibiotic, against Saccharomyces cerevisiae. Antimicrob. Agents Chemother. 41:672-676.
12. Fischl, A. S., Y. Liu, A. Browdy, and A. E. Cremesti. 2000. Inositolphosphoryl ceramide synthase from yeast. Methods Enzymol. 311:123-130.
13. Fuchs, N., S. Sonda, B. Gottstein, and A. Hemphill. 1998. Differential expression of cell surface- and dense granule-associated Neospora caninum proteins in tachyzoites and bradyzoites. J. Parasitol. 84:753-758.
14. Hannun, Y. A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1859.
15. Hashida-Okado, T., A. Ogawa, M. Endo, R. Yasumoto, K. Takesako, and I. Kato. 1996. AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells. Mol. Gen. Genet. 251:236-244.
16. + in cell morphogenesis. Curr. Genet. 33:38-45.
17. Heidler, S. A., and J. A. Radding. 2000. Inositol phosphoryl transferases from human pathogenic fungi. Biochim. Biophys. Acta 1500:147-152.
18. Hemphill, A., B. Gottstein, and H. Kaufmann. 1996. Adhesion and invasion of bovine endothelial cells by Neospora caninum. Parasitology 112:183-197.
19. Hemphill, A., and S. L. Croft. 1997. Electron microscopy in parasitology, p. 227-268. In M. Rogan (ed.), Analytical parasitology. Springer-Verlag, Heidelberg, Germany.
20. Kino, K., Y. Taguchi, K. Yamada, T. Komano, and K. Ueda. 1996. Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins. FEBS Lett. 399:29-32.
21. Lester, R. L., and R. C. Dickson. 1993. Sphingolipids with inositolphosphate-containing head groups. Adv. Lipid Res. 26:253-274.
22. Mandala, S. M., R. A. Thornton, J. Milligan, M. Rosenbach, M. Garcia-Calvo, H. G. Bull, G. Harris, G. K. Abruzzo, A. M. Flattery, C. J. Gill, K. Bartizal, S. Dreikorn, and M. B. Kurtz. 1998. Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J. Biol. Chem. 273:14942-14949.
23. Mathias, S., L. A. Pena, and R. N. Kolesnick. 1998. Signal transduction of stress via ceramide. Biochem. J. 335:465-480.
24. McAllister, M. M., S. F. Parmley, L. M. Weiss, V. J. Welch, and A. M. McGuire. 1996. An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigen. J. Parasitol. 82:354-355.
25. McConville, M. J., and A. Bade. 1989. A family of glycoinositol phospholipids from Leishmania major. Isolation, characterization, and antigenicity. J. Biol. Chem. 264:757-766.
26. McFadden, D. C., M. Camps, and J. C. Boothroyd. 2001. Resistance as a tool in the study of old and new drug targets in Toxoplasma. Drug Resist. Updat. 4:79-84.
27. McFadden, D. C., F. Seeber, and J. C. Boothroyd. 1997. Use of Toxoplasma gondii expressing beta-galactosidase for colorimetric assessment of drug activity in vitro. Antimicrob. Agents Chemother. 41:1849-1853.
28. Roberts, F., C. W. Roberts, J. J. Johnson, D. E. Kyle, T. Krell, J. R. Coggins, G. H. Coombs, W. K. Milhous, S. Tzipori, D. J. Ferguson, D. Chakrabarti, and R. McLeod. 1998. Evidence for the shikimate pathway in apicomplexan parasites. Nature 393:801-805.
29. Salto, M. L., L. E. Bertello, M. Vieira, R. Docampo, S. N. Moreno, and R. M. de Lederkremer. 2003. Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote. Eukaryot. Cell 2:756-768.
30. Sauvage, V., D. Aubert, A. Bonhomme, J. M. Pinon, and J. M. Millot. 2004. P-glycoprotein inhibitors modulate accumulation and efflux of xenobiotics in extra and intracellular Toxoplasma gondii. Mol. Biochem. Parasitol. 134:89-95.
31. Seeber, F., and J. C. Boothroyd. 1996. Escherichia coli beta-galactosidase as an in vitro and in vivo reporter enzyme and stable transfection marker in the intracellular protozoan parasite Toxoplasma gondii. Gene 169:39-45.
32. Silverman, J. A., M. L. Hayes, B. J. Luft, and K. A. Joiner. 1997. Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology. Antimicrob. Agents Chemother. 41:1859-1866.
33. Soete, M., D. Camus, and J. F. Dubremetz. 1994. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro. Exp. Parasitol. 78:361-370.
34. Takesako, K., K. Ikai, F. Haruna, M. Endo, K. Shimanaka, E. Sono, T. Nakamura, I. Kato, and H. Yamaguchi. 1991. Aureobasidins, new antifungal antibiotics. Taxonomy, fermentation, isolation, and properties. J. Antibiot. (Tokyo) 44:919-924.
35. Takesako, K., H. Kuroda, T. Inoue, F. Haruna, Y. Yoshikawa, I. Kato, K. Uchida, T. Hiratani, and H. Yamaguchi. 1993. Biological properties of aureobasidin A, a cyclic depsipeptide antifungal antibiotic. J. Antibiot. (Tokyo) 46:1414-1420.
36. Tiberghien, F., T. Kurome, K. Takesako, A. Didier, T. Wenandy, and F. Loor. 2000. Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter. J. Med. Chem. 43:2547-2556.
37. Wei, S., F. Marches, B. Daniel, S. Sonda, K. Heidenreich, and T. Curiel. 2002. Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication. Int. J. Parasitol. 32:969-977.
38. Weiss, L. M., and K. Kim. 2000. The development and biology of bradyzoites of Toxoplasma gondii. Front. Biosci. 5:D391-D405.
39. Weiss, L. M., D. Laplace, P. M. Takvorian, H. B. Tanowitz, A. Cali, and M. Wittner. 1995. A cell culture system for study of the development of Toxoplasma gondii bradyzoites. J. Eukaryot. Microbiol. 42:150-157.
40. Wong, S. Y., and J. S. Remington. 1993. Biology of Toxoplasma gondii. AIDS 7:299-316.