Selective gene therapy for proliferative disorders: Sense and antisense

Nature Medicine

Volumn 2, Issue 6, 1996, Pages 634-635

  Indolfi, Giro ^a   Chiariello, Massimo ^a   Avvedimento, Enrico V ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE;

ATHEROSCLEROSIS; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; GENE THERAPY; NOTE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; ARTERIOSCLEROSIS; CELL DIVISION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE THERAPY; GENES, RAS; HUMANS; MICE; MODELS, BIOLOGICAL; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 19144363671     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0696-634     Document Type: Note

References (11)

1. Ross, R. The pathogenesis of atherosclerosis, a perspective for the 1990's. Nature 362, 801-809 (1993).
2. Ludwig, S. & Rapp, U.R. Cascading towards vascular disorder gene therapy. Nature Med. 1, 513-515 (1995).
3. Krontiris TG. Oncogenes. New Engl. J. Med. 5, 303-306 (1995).
4. Kohl, N. E. et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 260, 1934-1937 (1993).
5. Indolfi, C. et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nature Med. 1, 541-545 (1995).
6. Wagner, R.W. The state of the art in antisense research, feature Med. 1, 1116-1118 (1995).
7. Stein, C.A. Does antisense exist? Nature Med. 1, 1119-1121 (1995).
8. Monia, B.P. et al. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nature Med. 2, 668-675 (1996)
9. Holt, J.T. et al. A 'senseless' immune response to DNAs. Nature Med. 1, 407-408 (1995).
10. Yokozaki, H. et al. Unhydrolyzable analogue of adenosise 3′-5′-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 52, 2504-2508 (1992).
11. Grieco, D. et al. Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphase. Science 271, 1718-1722 (1996).