-
1
-
-
0032748141
-
Role of hypothalamic neuropeptide Y in feeding and obesity
-
D.R. Gehlert Role of hypothalamic neuropeptide Y in feeding and obesity Neuropeptides 33 1999 329 338
-
(1999)
Neuropeptides
, vol.33
, pp. 329-338
-
-
Gehlert, D.R.1
-
3
-
-
0036111124
-
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects on neuropeptide Y
-
A. Kask, J. Harro, S. von Horsten, J.P. Redrobe, Y. Dumont, and R. Quirion The neurocircuitry and receptor subtypes mediating anxiolytic-like effects on neuropeptide Y Neurosci Biobehav Rev 26 2002 259 283
-
(2002)
Neurosci Biobehav Rev
, vol.26
, pp. 259-283
-
-
Kask, A.1
Harro, J.2
Von Horsten, S.3
Redrobe, J.P.4
Dumont, Y.5
Quirion, R.6
-
4
-
-
0038663071
-
Neuropeptide Y (NPY) family of hormones: Progress in the development of receptor selective agonists and antagonists
-
A. Balasubramaniam Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists Curr Pharm Des 9 2003 1165 1175
-
(2003)
Curr Pharm des
, vol.9
, pp. 1165-1175
-
-
Balasubramaniam, A.1
-
5
-
-
0242406759
-
Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs
-
N.R. Levens, and O. Della-Zuana Neuropeptide Y Y5 receptor antagonists as anti-obesity drugs Curr Opin Invest Drugs 4 2003 1198 1204
-
(2003)
Curr Opin Invest Drugs
, vol.4
, pp. 1198-1204
-
-
Levens, N.R.1
Della-Zuana, O.2
-
6
-
-
0032901784
-
Characterization of neuropeptide Y-induced feeding in mice: Do Y1-Y6 receptor subtypes mediate feeding?
-
S. Iyengar, D.L. Li, and RM.A. Simmons Characterization of neuropeptide Y-induced feeding in mice: do Y1-Y6 receptor subtypes mediate feeding? J Pharmacol Exp Ther 289 1999 1031 1040
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1031-1040
-
-
Iyengar, S.1
Li, D.L.2
Simmons, R.A.3
-
7
-
-
0030840674
-
Y-receptor subtypes - How many more?
-
A.G. Blomqvist, and H. Herzog Y-receptor subtypes - how many more? Trends Neurosci 20 1997 294 298
-
(1997)
Trends Neurosci
, vol.20
, pp. 294-298
-
-
Blomqvist, A.G.1
Herzog, H.2
-
8
-
-
0031919929
-
XVI. International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors
-
M.C. Michel, A.G. Beck-Sickinger, H. Cox, H.N. Doods, H. Herzog, and D. Larhammar XVI. International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors Pharmacol Rev 50 1998 143 150
-
(1998)
Pharmacol Rev
, vol.50
, pp. 143-150
-
-
Michel, M.C.1
Beck-Sickinger, A.G.2
Cox, H.3
Doods, H.N.4
Herzog, H.5
Larhammar, D.6
-
9
-
-
3643132240
-
Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains
-
Y. Dumont, D. Jacques, P. Bouchard, and R. Quirion Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains J Comp Neurol 402 1998 372 384
-
(1998)
J Comp Neurol
, vol.402
, pp. 372-384
-
-
Dumont, Y.1
Jacques, D.2
Bouchard, P.3
Quirion, R.4
-
10
-
-
0035091620
-
Emerging functions of neuropeptide Y Y(2) receptors in the brain
-
T. Kaga, M. Fujimiya, and A. Inui Emerging functions of neuropeptide Y Y(2) receptors in the brain Peptides 22 2001 501 506
-
(2001)
Peptides
, vol.22
, pp. 501-506
-
-
Kaga, T.1
Fujimiya, M.2
Inui, A.3
-
11
-
-
1342265788
-
Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano- phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor
-
P. Bonaventure, D. Nepomuceno, C. Mazur, B. Lord, D.A. Rudolph, and J.A. Jablonowski Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3- cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor J Pharmacol Exp Ther 308 2004 1130 1137
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 1130-1137
-
-
Bonaventure, P.1
Nepomuceno, D.2
Mazur, C.3
Lord, B.4
Rudolph, D.A.5
Jablonowski, J.A.6
-
12
-
-
0032861562
-
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
-
P. Naveilhan, H. Hassani, J.M. Canals, A.J. Ekstrand, A. Larefalk, and V. Chhajlani Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor Nat Med 5 1999 1188 1193
-
(1999)
Nat Med
, vol.5
, pp. 1188-1193
-
-
Naveilhan, P.1
Hassani, H.2
Canals, J.M.3
Ekstrand, A.J.4
Larefalk, A.5
Chhajlani, V.6
-
14
-
-
0041859261
-
Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36
-
R.L. Batterham, M.A. Cohen, S.M. Ellis, C.W. Le Roux, D.J. Withers, and G.S. Frost Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36 N Engl J Med 349 2003 941 948
-
(2003)
N Engl J Med
, vol.349
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
Le Roux, C.W.4
Withers, D.J.5
Frost, G.S.6
-
15
-
-
2942662404
-
"it's the chemistry, stupid!", or: The impact of early discovery patent applications on the drug development process
-
F. Landolt "It's the chemistry, stupid!", or: the impact of early discovery patent applications on the drug development process Curr Top Med Chem 4 2004 601 608
-
(2004)
Curr Top Med Chem
, vol.4
, pp. 601-608
-
-
Landolt, F.1
-
16
-
-
85030797190
-
-
Uses of nucleic acid encoding neuropeptide Y/peptide YY (Y2) receptors nucleic acid encoding. PCT Int. Appl. WO9521245, Synaptic Pharma Corp., USA
-
Gerald C, Weinshank RL, Walker MW, Branchek T. Uses of nucleic acid encoding neuropeptide Y/peptide YY (Y2) receptors nucleic acid encoding. PCT Int. Appl. WO9521245, Synaptic Pharma Corp., USA, 1996.
-
(1996)
-
-
Gerald, C.1
Weinshank, R.L.2
Walker, M.W.3
Branchek, T.4
-
17
-
-
85030795865
-
-
DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof. PCT Int. Appl. US5989834, Synaptic Pharma Corp., USA, 1999.
-
Gerald C, Weinshank RL, Walker MW, Branchek T. DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof. PCT Int. Appl. US5989834, Synaptic Pharma Corp., USA, 1999.
-
-
-
Gerald, C.1
Weinshank, R.L.2
Walker, M.W.3
Branchek, T.4
-
18
-
-
85030805482
-
-
Method of obtaining compositions comprising Y2 specific compounds. PCT Int. Appl. US6420532 (Synaptic Pharma Corp., USA) 2002.
-
Gerald C, Weinshank RL, Walker MW, Branchek T. Method of obtaining compositions comprising Y2 specific compounds. PCT Int. Appl. US6420532 (Synaptic Pharma Corp., USA) 2002.
-
-
-
Gerald, C.1
Weinshank, R.L.2
Walker, M.W.3
Branchek, T.4
-
19
-
-
0030607178
-
Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor
-
Rist B, Zerbe O, Ingenhoven N, Scapozza L, Peers C, Vaughan PF, McDonald RL, Wieland HA, Beck-Sickinger AG. Modified, cyclic dodecapeptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor. FEBS Lett 1996; 394:pp. 169-73.
-
(1996)
FEBS Lett
, vol.394
, pp. 169-173
-
-
Rist, B.1
Zerbe, O.2
Ingenhoven, N.3
Scapozza, L.4
Peers, C.5
Vaughan, P.F.6
McDonald, R.L.7
Wieland, H.A.8
Beck-Sickinger, A.G.9
-
21
-
-
85030802945
-
Establishment of robust functional assays for the characterization of Neuropeptide Y (NPY) receptors: Identification of 3-(5-Benzoyl-thiazol-2- ylamino)-benzonitrile as selective NPY type 5 receptor antagonist
-
in press.
-
Dautzenberg FM, Higelin J, Pflieger P, Neidhart W, Guba W. Establishment of robust functional assays for the characterization of Neuropeptide Y (NPY) receptors: identification of 3-(5-Benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist. Neuropharmacology, in press.
-
Neuropharmacology
-
-
Dautzenberg, F.M.1
Higelin, J.2
Pflieger, P.3
Neidhart, W.4
Guba, W.5
-
22
-
-
0342749308
-
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor
-
S. Rover, G. Adam, A.M. Cesura, G. Galley, F. Jenck, and F.J. Monsma Jr High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor J Med Chem 43 2000 1329 1338
-
(2000)
J Med Chem
, vol.43
, pp. 1329-1338
-
-
Rover, S.1
Adam, G.2
Cesura, A.M.3
Galley, G.4
Jenck, F.5
Monsma Jr., F.J.6
-
23
-
-
0034920548
-
Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: Rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo
-
F.M. Dautzenberg, J. Wichmann, J. Higelin, G. Py-Lang, C. Kratzeisen, and P. Malherbe Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo J Pharmacol Exp Ther 298 2001 812 819
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 812-819
-
-
Dautzenberg, F.M.1
Wichmann, J.2
Higelin, J.3
Py-Lang, G.4
Kratzeisen, C.5
Malherbe, P.6
-
25
-
-
0035091968
-
Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319
-
E. Grouzmann, C. Meyer, E. Burki, and H. Brunner Neuropeptide Y Y2 receptor signalling mechanisms in the human glioblastoma cell line LN319 Peptides 22 2001 379 386
-
(2001)
Peptides
, vol.22
, pp. 379-386
-
-
Grouzmann, E.1
Meyer, C.2
Burki, E.3
Brunner, H.4
-
26
-
-
0038727630
-
The gut hormone peptide YY regulates appetite
-
R.L. Batterham, and S.R. Bloom The gut hormone peptide YY regulates appetite Ann N Y Acad Sci 994 2003 162 168
-
(2003)
Ann N Y Acad Sci
, vol.994
, pp. 162-168
-
-
Batterham, R.L.1
Bloom, S.R.2
-
28
-
-
10744220302
-
Novel non-peptidic neuropeptide Y Y2 receptor antagonists
-
J.A. Jablonowski, W. Chai, X. Li, D.A. Rudolph, W.V. Murray, and M.A. Youngman Novel non-peptidic neuropeptide Y Y2 receptor antagonists Bioorg Med Chem Lett 14 2004 1239 1242
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 1239-1242
-
-
Jablonowski, J.A.1
Chai, W.2
Li, X.3
Rudolph, D.A.4
Murray, W.V.5
Youngman, M.A.6
-
29
-
-
0024502906
-
Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines
-
S.P. Sheikh, M.M. O'Hare, O. Tortora, and T.W. Schwartz Binding of monoiodinated neuropeptide Y to hippocampal membranes and human neuroblastoma cell lines J Biol Chem 264 1989 6648 6654
-
(1989)
J Biol Chem
, vol.264
, pp. 6648-6654
-
-
Sheikh, S.P.1
O'Hare, M.M.2
Tortora, O.3
Schwartz, T.W.4
-
30
-
-
0032566841
-
Structure-activity relationships with neuropeptide Y analogues: A comparison of human Y1-, Y2- and rat Y2-like systems
-
H.M. Cox, I.R. Tough, N. Ingenhoven, and A.G. Beck-Sickinger Structure-activity relationships with neuropeptide Y analogues: a comparison of human Y1-, Y2- and rat Y2-like systems Regul Pept 75-76 1998 3 8
-
(1998)
Regul Pept
, vol.75-76
, pp. 3-8
-
-
Cox, H.M.1
Tough, I.R.2
Ingenhoven, N.3
Beck-Sickinger, A.G.4
-
31
-
-
0028286251
-
Y2 receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line
-
Y. Shigeri, and M. Fujimoto Y2 receptors for neuropeptide Y are coupled to three intracellular signal transduction pathways in a human neuroblastoma cell line J Biol Chem 269 1994 8842 8848
-
(1994)
J Biol Chem
, vol.269
, pp. 8842-8848
-
-
Shigeri, Y.1
Fujimoto, M.2
-
32
-
-
0033151694
-
Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors
-
P. Coward, S.D. Chan, H.G. Wada, G.M. Humphries, and B.R. Conklin Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors Anal Biochem 270 1999 242 248
-
(1999)
Anal Biochem
, vol.270
, pp. 242-248
-
-
Coward, P.1
Chan, S.D.2
Wada, H.G.3
Humphries, G.M.4
Conklin, B.R.5
-
33
-
-
0032946236
-
Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors
-
S. An, T. Bleu, and Y. Zheng Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors Mol Pharmacol 55 1999 787 794
-
(1999)
Mol Pharmacol
, vol.55
, pp. 787-794
-
-
An, S.1
Bleu, T.2
Zheng, Y.3
|