Photobiological and ultrastructural studies of nanoparticles of poly(lactic-co-glycolic acid)-containing bacteriochlorophyll-a as a photosensitizer useful for PDT treatment

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 12, Issue 3, 2005, Pages 159-164

  Gomes, Anderson J ^a   Lunardi, Laurelúcia O ^b   Marchetti, Juliana M ^c   Lunardi, Claure N ^d   Tedesco, Antonio C ^d,e  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Faculdade Odontol de Ribeirao Preto   (Brazil)

^c Faculdade Cie Farmaceuticas R   (Brazil)

^d Faculdade Filos Cie Letras R   (Brazil)

^e UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bacteriochlorophyll a; Nanoparticle; Photodynamic Therapy; Ultrastructural

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BACTERIOCHLOROPHYLL A; GLYCOLIC ACID DERIVATIVE; NANOPARTICLE; PHOTOSENSITIZING AGENT; POLY(LACTIC CO GLYCOLIC ACID); POLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIODEGRADABILITY; CELL ADHESION; CELL SURFACE; CELL SURVIVAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DYE LASER; HYDROPHOBICITY; IN VITRO STUDY; INCUBATION TIME; LASER; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TUMOR CELL;

ANIMALS; BACTERIOCHLOROPHYLL A; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; DATA INTERPRETATION, STATISTICAL; LACTIC ACID; LIGHT; MACROPHAGES; MICROSCOPY, ELECTRON, SCANNING; NANOSTRUCTURES; PARTICLE SIZE; PHAGOCYTOSIS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYGLYCOLIC ACID; POLYMERS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 18044391848     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540590931846     Document Type: Article

References (20)

1. Ashsan, F., Rivas, I. P., Khan, M. A., and Suárez, A. I. T. 2002. Targeting to macrophage: role of physicochemical properties of paniculate carriers - liposomes and microsphere - on the phagocytosis by macrophage. J. Control. Rel. 79:29-40.
2. Borland, C. F., McGarvey, D. J., and Truscott, T. G. 1987. Photophysical studies of bacteriochlorophyll-a and bacteriopheophytin-a - singlet oxygen generation. J. Photochem. Photobiol. B: Biol. 1:93-101.
3. Chen, W., and Lu, D. R. 1999. Carboplatin-loaded PLGA microspheres for intracerebral injection: formulation and characterization. J. Microencapsul. 16:551-563.
4. Crotts, G., and Park, T. G. 1998. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microsphere: release kinetics and stability issues. J. Microencapsul. 15:699-713.
5. Cui, Z., and Mumper, R. J. 2003. The effect of co-administration of an adjuvant with nanoparticle-based genetic vaccine delivery system on the resulting immune response. Eur. J. Pharm. Biopharm. 55:11-18.
6. Demoiseau, X., Schuitmaker, H. J., Lagerberg J. W. M., and Hoebeke, M. 2001. Increase of the photosensitizing efficiency of the bacteriochlorin-a by liposome-incorporation. J. Photochem. Photobiol. B: Biol. 60:50-60.
7. Dune, M., Corrigan, O. I., and Ramtoola, Z. 2000. Influence of particle size and dissolution conditions on the degradation properties of polylactice-Coglycolide particles. Biomaterials 21:1659-1668.
8. Esposito, E., Sebben, S., Cortesi, R., Menegatti, E., and Nastruzzi, C. 1999. Preparation and characterization of cationic microspheres for gene delivery. International Journal of Pharmaceutics 189:29-41.
9. Fu, F., Li, X., Ng, D. K. P., and Wu, C. 2002. Encapsulation of phthalocyanines in biodegradable poly(sebacic anhydride) nanoparticles. Langmuir 18:3843-3847.
10. Garcia, J. T., Farina, J. B., Munguia, O., and LLabrés, M. 1999. Comparative degradation study of biodegradable microspheres of poly(dl-lactide-coglycolide) with poly(ethyleneglycol) derivates. J. Microencapsul. 16:83-94.
11. Grahn, M. F., McGuinness, A., Benzie., R., Boyle, R., Jode, M. L., Dilkes, M. G., Abbas, B., and Willians, N. S. 1997. Intracellular uptake, absorption spectrum and stability of the bacteriochlorin photosensitizer 5,10,15,20-tetrakis(m-hydroxyphenyl)bacteriochlorin (mTHPBC). Comparison with 5,10,15,20-tetrakis(m-hydroxyfenyl)chlorine (mTHPC). J. Photochem. Photobiol. B: Biol. 37:261-266.
12. Henderson, B. W., Sumlin, A. B., Owczarczak, B. L., and Dougherty, T. J. 1991. Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors. J. Photochem. Photobiol. B: Biol. 10:303-313.
13. Jiao, Y., Ubrich, N., Marchand-Arvier, M., Vigneron, C., Hoffman, M., Lecompte, T., and Maincent, P. 2002. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation 105:230-235.
14. Konan, Y. N., Chevallier, J., Gurny, R., and Allémann, E. 2003. Encapsulation of p-THPP into nanoparticles: cellular uptake, subcellular localization and effect of serum on the photodynamic activity. Photochem. Photobiol. 77:638-644.
15. Moghimi, S. M., Hunter, A. C., and Murray, J. C. 2001. Long-circulation and target-specific nanoparticles: theory to pratice. Pharmacol. Rev. 53:283-318.
16. Moser, J. G. 1998. Photodynamic tumor therapy: 2nd and 3rd generation photosensitizer, 3-6, 43-49. New Delhi, India: Harwood Academic Publishers.
17. Ochsner, M. 1997. Photophysical and photobiological processes in the photodynamic therapy of tumors. J. Photochem. Photobiol. B: Biol. 39:1-18.
18. Okawa, T., Ichimal, H., Ishida, T., Kawata, M., Kaguba, S., Mamba, K., and Makita, T. 1989. Implication of activation of intraperitoneal macrophages with biodegradable microsphere. Cell Biol. Int. Rep. 13:547-553.
19. Panyam, J., Zhou, W. Z., Prabha, S., Sahoo, S. K., and Labhasetwar, V. 2002. Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticle: implications for drug and gene delivery. FASEB J. 16:1217-1226.
20. Van Tenten, Y., Schuitmaker, J. J., De Groot, V., Willekens, B., Vrensen, G. F. J. M., and Tassignón, M. J. 2000. Cell biological mechanisms underlying posterior capsule opacification: search for a therapy. Bull. Soc. Belge Ophthalmol 278:61-66.