Characterization of superoxide production sites in isolated rat brain and skeletal muscle mitochondria

Biomedicine and Pharmacotherapy

Volumn 59, Issue 4, 2005, Pages 163-168

  Kudin, Alexey P ^a   Debska Vielhaber, Grazyna ^a   Kunz, Wolfram S ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Complex I; Complex III; Hydrogen peroxide; Rat brain mitochondria; Rat skeletal muscle mitochondria; Superoxide

Indexed keywords

4 HYDROXYPHENYLACETIC ACID; CITRININ; FLUORESCENT DYE; HYDROETHIDINE; HYDROGEN PEROXIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; SUCCINIC ACID; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; DATA ANALYSIS; ELECTRON TRANSPORT; EVALUATION; MITOCHONDRIAL RESPIRATION; MUSCLE MITOCHONDRION; NONHUMAN; OXYGEN SATURATION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; SKELETAL MUSCLE;

EID: 18044391656     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2005.03.012     Document Type: Article

References (22)

1. K. Keyer, and J.A. Imlay Superoxide accelerates DNA damage by elevating free-iron levels Proc Natl Acad Sci USA 93 1996 13635 13640
2. 2 in the production of HO: in vitro and in vivo Free Radic Biol Med 16 1994 29 33
3. B. Halliwell Reactive oxygen species and the central nervous system J Neurochem 59 1992 1609 1623
4. M.F. Beal Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme q(10) as a potential treatment J Bioenerg Biomembr 36 2004 381 386
5. D.R. Rosen, T. Siddique, D. Patterson, D.A. Figlewicz, P. Sapp, and A. Hentati Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
6. A. Boveris, E. Cadenas, and A.O. Stoppani Role of ubiquinone in the mitochondrial generation of hydrogen peroxide Biochem J 156 1976 435 444
7. J.F. Turrens, and A. Boveris Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria Biochem J 191 1980 421 427
8. M.L. Genova, B. Ventura, G. Giuliano, C. Bovina, G. Formiggini, and G. Parenti Castelli The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2 FEBS Lett 505 2001 364 368
9. A.P. Kudin, N.Y. Bimpong-Buta, S. Vielhaber, C.E. Elger, and W.S. Kunz Characterization of superoxide-producing sites in isolated brain mitochondria J Biol Chem 279 2004 4127 4135
10. A.J. Lambert, and M.D. Brand Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) J Biol Chem 279 2004 39414 39420
11. Y. Liu, G. Fiskum, and D. Schubert Generation of reactive oxygen species by the mitochondrial electron transport chain J Neurochem 80 5 2002 780 787
12. Y. Kushnareva, A.N. Murphy, and A. Andreyev Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state Biochem J 368 2002 545 553
13. A. Naqui, B. Chance, and E. Cadenas Reactive oxygen intermediates in biochemistry Annu Rev Biochem 55 1986 137 166
14. P.M. Wood The redox potential of the system oxygen-superoxide FEBS Lett 44 1974 22 24
15. A.A. Starkov, G. Fiskum, C. Chinopoulos, B.J. Lorenzo, S.E. Browne, and M.S. Patel Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species J Neurosci 24 2004 7779 7788
16. J. St-Pierre, J.A. Buckingham, S.J. Roebuck, and M.D. Brand Topology of superoxide production from different sites in the mitochondrial electron transport chain J Biol Chem 277 2002 44784 44790
17. E. Wisniewski, W.S. Kunz, and F.N. Gellerich Phosphate affects the distribution of flux control among the enzymes of oxidative phosphorylation in rat skeletal muscle mitochondria J Biol Chem 268 1993 9343 9346
18. V.P. Bindokas, J. Jordan, C.C. Lee, and R.J. Miller Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine J Neurosci 16 1996 1324 1336
19. C.C. Winterbourn, H.N. Parsons-Mair, S. Gebicki, J.M. Gebicki, and M.J. Davies Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides Biochem J 381 2004 241 248
20. 2 production from mitochondrial respiratory chain Biochem Biophys Res Commun 281 2001 645 650
21. T.V. Votyakova, and I.J. Reynolds Detection of hydrogen peroxide with Amplex Red: interference by NADH and reduced glutathione auto-oxidation Arch Biochem Biophys 431 2004 138 144
22. S. Kamzalov, N. Sumien, M.J. Forster, and R.S. Sohal Coenzyme Q intake elevates the mitochondrial and tissue levels of coenzyme Q and α-tocopherol in young mice J Nutr 133 2003 3175 3180