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A gene controlling variation in Arabidopsis thaliana glucosinolate composition is part of the methionine chain elongation pathway
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J. Kroymann, S. Textor, J.G. Tokuhisa, K.L. Falk, S. Bartram, J. Gershenzon, and T. Mitchell-Olds A gene controlling variation in Arabidopsis thaliana glucosinolate composition is part of the methionine chain elongation pathway Plant Physiol 127 2001 1077 1088
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Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: Recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain elongation cycle
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S. Textor, S. Bartram, J. Kroymann, K.L. Falk, A. Hick, J.A. Pickett, and J. Gershenzon Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the condensing enzyme of the chain elongation cycle Planta 218 2004 1026 1035
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Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate
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U. Wittstock, and B.A. Halkier Cytochrome P450 CYP79A2 from Arabidopsis thaliana L. catalyzes the conversion of L-phenylalanine to phenylacetaldoxime in the biosynthesis of benzylglucosinolate J Biol Chem 275 2000 14659 14666
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Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis
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A.K. Hull, V. Rekha, and J.L. Celenza Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis Proc Natl Acad Sci USA 97 2000 2379 2384
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Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid
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M.D. Mikkelsen, C.H. Hansen, U. Wittstock, and B.A. Halkier Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid J Biol Chem 275 2000 33712 33717
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Cytochrome P450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates
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C.H. Hansen, U. Wittstock, C.E. Olsen, A.J. Hick, J.A. Pickett, and B.A. Halkier Cytochrome P450 CYP79F1 from Arabidopsis catalyzes the conversion of dihomomethionine and trihomomethionine to the corresponding aldoximes in the biosynthesis of aliphatic glucosinolates J Biol Chem 276 2001 11078 11085
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CYP83B1 is the oxime-metabolizing enzyme in the glucosinolate pathway in Arabidopsis
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C.H. Hansen, L. Du, P. Naur, C.E. Olsen, K.B. Axelsen, A.J. Hick, J.A. Pickett, and B.A. Halkier CYP83B1 is the oxime-metabolizing enzyme in the glucosinolate pathway in Arabidopsis J Biol Chem 276 2001 24790 24796
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CYP83B1, a cytochrome P450 at the metabolic branch point in auxin and indole glucosinolate biosynthesis in Arabidopsis
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S. Bak, F.E. Tax, K.A. Feldmann, D.W. Galbraith, and R. Feyereisen CYP83B1, a cytochrome P450 at the metabolic branch point in auxin and indole glucosinolate biosynthesis in Arabidopsis Plant Cell 13 2001 101 111
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Bus, a bushy Arabidopsis CYP79F1 knockout mutant with abolished synthesis of short-chain aliphatic glucosinolates
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B. Reintanz, M. Lehnen, M. Reichelt, J. Gershenzon, M. Kowalczyk, G. Sandberg, M. Godde, R. Uhl, and K. Palme bus, a bushy Arabidopsis CYP79F1 knockout mutant with abolished synthesis of short-chain aliphatic glucosinolates Plant Cell 13 2001 351 367
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Sandberg, G.6
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Arabidopsis cytochrome P450 cyp83B1 mutations activate the tryptophan biosynthetic pathway
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G. Smolen, and J. Bender Arabidopsis cytochrome P450 cyp83B1 mutations activate the tryptophan biosynthetic pathway Genetics 160 2002 323 332
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Trp-dependent auxin biosynthesis in Arabidopsis: Involvement of cytochrome P450s CYP72B2 and CYP79B3
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Y. Zhao, A.K. Hull, N.R. Gupta, K.A. Goss, J. Alonso, J.R. Ecker, J. Normanly, J. Chory, and J.L. Celenza Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP72B2 and CYP79B3 Genes Dev 16 2002 3100 3112
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Zhao, Y.1
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Normanly, J.7
Chory, J.8
Celenza, J.L.9
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12
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CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis
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S. Chen, E. Glawischnig, K. Jorgensen, P. Naur, B. Jorgensen, C.E. Olsen, C.H. Hansen, H. Rasmussen, J.A. Pickett, and B.A. Halkier CYP79F1 and CYP79F2 have distinct functions in the biosynthesis of aliphatic glucosinolates in Arabidopsis Plant J 33 2003 923 937 The authors find that CYP79F1 metabolizes mono- to hexahomo-methionine whereas CYP79F2 exclusively functions in the metabolism of penta- and hexahomo-methionine. This situation is reminiscent of the GS-Elong and GS-AOP loci where tandemly arrayed genes are transcribed to form enzymes that display overlapping but not identical substrate specificities. This work highlights the importance of gene duplication and subsequent functional diversification in the evolution of glucosinolate biosynthesis and breakdown.
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Chen, S.1
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Hansen, C.H.7
Rasmussen, H.8
Pickett, J.A.9
Halkier, B.A.10
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CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis
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P. Naur, B.L. Petersen, M.D. Mikkelsen, S. Bak, H. Rasmussen, C.E. Olsen, and B.A. Halkier CYP83A1 and CYP83B1, two nonredundant cytochrome P450 enzymes metabolizing oximes in the biosynthesis of glucosinolates in Arabidopsis Plant Physiol 133 2003 63 72
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The Arabidopsis ref2 mutant is defective in the gene encoding CYP83A1 and shows both phenylpropanoid and glucosinolate phenotypes
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M.R. Hemm, M.O. Ruegger, and C. Chapple The Arabidopsis ref2 mutant is defective in the gene encoding CYP83A1 and shows both phenylpropanoid and glucosinolate phenotypes Plant Cell 15 2003 179 194
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Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis
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E. Glawischnig, B.G. Hansen, C.E. Olsen, and B.A. Halkier Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis Proc Natl Acad Sci USA 101 2004 8245 8250 The authors demonstrate that indole glucosinolates and camalexin are synthesized from indole-3-acetaldoxime by different reactions. Their work indicates that indole-3-acetaldoxime is a key branching point of primary metabolism and several secondary metabolic pathways.
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Proc Natl Acad Sci USA
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Glawischnig, E.1
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Functional analysis of the tandem-duplicated P450 genes SPS/BUS/CYP79F1 and CYP79F2 in glucosinolate biosynthesis and plant development by Ds transposition-generated double mutants
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T. Tantikanjana, M.D. Mikkelsen, M. Hussain, B.A. Halkier, and V. Sundaresan Functional analysis of the tandem-duplicated P450 genes SPS/BUS/CYP79F1 and CYP79F2 in glucosinolate biosynthesis and plant development by Ds transposition-generated double mutants Plant Physiol 135 2004 840 848
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Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis
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M.D. Mikkelsen, P. Naur, and B.A. Halkier Arabidopsis mutants in the C-S lyase of glucosinolate biosynthesis establish a critical role for indole-3-acetaldoxime in auxin homeostasis Plant J 37 2004 770 777
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Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis
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C.D. Grubb, B.J. Zipp, J. Ludwig-Müller, M.N. Masuno, T.F. Molinski, and S. Abel Arabidopsis glucosyltransferase UGT74B1 functions in glucosinolate biosynthesis and auxin homeostasis Plant J 40 2004 893 903
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M. Piotrowski, A. Schemenewitz, A. Lopukhina, A. Müller, T. Janowitz, E.W. Weiler, and C. Oecking Desulfoglucosinolate sulfotransferases from Arabidopsis thaliana catalyze the final step in the biosynthesis of the glucosinolate core structure J Biol Chem 279 2004 50717 50725
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J.T. Romeo Pergamon
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A.N. Capella, M. Menossi, P. Arruda, and C.E. Benedetti COI1 affects myrosinase activity and controls the expression of two flower-specific myrosinase-binding protein homologues in Arabidopsis thaliana Planta 213 2001 691 699
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S. Eriksson, E. Andréasson, B. Ekbom, G. Graner, B. Pontoppidan, J. Taipalensuu, J. Zhang, L. Rask, and J. Meijer Complex formation of myrosinase isoenzymes in oilseed rape seeds are dependent on the presence of myrosinase-binding proteins Plant Physiol 129 2002 1592 1599
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H. Husebye, S. Chadchawan, P. Winge, O.P. Thangstad, and A.M. Bones Guard cell- and phloem idioblast-specific expression of thioglucoside glucohydrolase 1 (myrosinase) in Arabidopsis Plant Physiol 128 2002 1180 1188
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