Molecular bases of hprt mutations in malathion-treated human T- lymphocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 397, Issue 2, 1998, Pages 137-148

  Pluth, Janice M ^a,b   Patrick O'Neill, J ^a   Nicklas, Janice A ^a   Albertini, Richard J ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

Hprt mutation spectra; Human T lymphocyte; Malathion

Indexed keywords

MALATHION;

ALKYLATION; ARTICLE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; T LYMPHOCYTE;

HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INSECTICIDES; MALATHION; MALE; MUTATION; POLYMERASE CHAIN REACTION; RNA SPLICING; SEQUENCE DELETION; T-LYMPHOCYTES;

EID: 0032472924     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00200-5     Document Type: Article

References (25)

1. Herath J.F., Jala S.M., Ebert M.J., Martsolf J.T. Genotoxicity of the organophosphorus insecticide malathion based on human lymphocytes in culture. Cytologia. 54:1989;191-195.
2. Garry V., Nelson R., Griffith J., Harkins M. Preparation for human study of pesticide applicators: sister chromatid exchanges and chromosome aberrations in cultured human lymphocytes exposed to selected fumigants. Teratogen. Carcinogen. Mutagen. 10:1990;21-29.
3. Walter Z., Czajkowska A., Lipecka A. Effect of malathion on the genetic material of human lymphocytes stimulated by phytohemagglutinin (PHA). Hum. Genet. 53:1980;375-381.
4. Sobti R.C., Krishan A., Pfaffenberger C.D. Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates. Mutation Res. 102:1982;89-102.
5. Nicholas A., Vienne M., VanDenBerghe H. Induction of sister-chromatid exchanges in cultured human cells by an organophosphorous insecticide: malathion. Mutation Res. 67:1979;167-172.
6. van Bao T., Szabo I., Ruzicska P., Czeizel A. Chromosome aberrations in patients suffering acute organic phosphate insecticide intoxication. Humangenetik. 24:1974;33-57.
7. M. Eto, Organophosphorus Pesticides: Organic and Biological Chemistry, CRC Press, 1974, pp. 16-300.
8. R. Wiaderkiewicz, Z. Walter, W. Reimschussel, Sites of methylation of DNA bases by the action of organophosphorus insecticides in vitro, Acta Biochim. Pol. (1986) 73-85.
9. Imamura T., Talcott R.E. Mutagenic and alkylating activities of organophosphate impurities of commercial malathion. Mutation Res. 155:1985;1-6.
10. Pluth J.M., Nicklas J.A., O'Neill J.P., Albertini R.J. Increased frequency of specific genomic deletions resulting from in vitro malathion exposure. Cancer Res. 56:1996;2393-2399.
11. Cariello N.F. Software for the analysis of mutations at the human hprt gene. Mutation Res. 312:1994;173-185.
12. Nicklas J.A., Hunter T.C., Sullivan L.M., Berman J.K., O'Neill J.P., Albertini R.J. Molecular analyses of in vivo hprt mutations in human T-lymphocytes. I. Studies of low frequency 'spontaneous' mutants by Southern blots Mutagenesis. 2:1987;341-347.
13. Brennand J., Konecki D.S., Caskey C.T. Expression of human and Chinese hamster hypoxanthine-guanine phosphoribosyltransferase cDNA recombinants in cultured Lesch-Nyhan and Chinese hamster fibroblasts. J. Biol. Chem. 258:1983;9593-9596.
14. Yanagi Y., Chan A., Chin B., Minden M., Mak T.W. Analysis of cDNA clones specific for human T cells and the α and β chains of the T-cell receptor heterodimer from a human T-cell line. Proc. Natl. Acad. Sci. USA. 82:1985;3430-3434.
15. Lefranc M.-P., Rabbitts T.H. Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangements in different T-cell types. Nature. 316:1985;464-466.
16. Yang J.-L., Maher V.M., McCormick J.J. Amplification of cDNA from the lysate of a small clone of diploid human cells and direct DNA sequencing. Gene. 83:1989;347-354.
17. Jolly D.J., Okayama H., Berg P., Esty A.C., Filpula D., Bohlen P., Johnson G.G., Shively J.E., Hunkapillar T., Freidmann T. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyltransferase. Proc. Natl. Acad. Sci. USA. 80:1983;477-481.
18. Gibbs R.A., Nguyen P.N., Edwards A., Civitello A.B., Caskey C.T. Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families. Genomics. 7:1990;235-244.
19. O'Neill J.P., Hunter T.C., Sullivan L.M., Nicklas J.A., Albertini R.J. Southern blot analyses of human T-lymphocyte mutants induced in vitro by gamma irradiation. Mutation Res. 240:1990;143-149.
20. Edwards A., Voss H., Rice P., Civitello A., Stegemann J., Schwager C., Zimmerman J., Erfle H., Caskey C.T., Ansorge W. Automated DNA sequencing of the human HPRT locus. Genomics. 6:1990;593-608.
21. Cariello N.F., Craft T.R., Vrieling H., van Zeeland A.A., Adams T., Skopek T.R. Human HPRT mutant database: software for data entry and retrieval. Environ. Mol. Mutagen. 20:1992;81-83.
22. Cariello N.F., Skopek T.R. Analysis of mutation occurring at the human hprt locus. J. Mol. Biol. 231:1993;41-57.
23. Gui J.F., Lane W.S., Fu X.D. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 369:1994;678-683.
24. Manjanatha M.G., Lindsey L.A., Mittelstaedt R.A., Heflich R.H. Low hprt mRNA levels and multiple hprt mRNA species in 6-thioguanine-resistant Chinese hamster cell mutants possessing nonsense mutations. Mutation Res. 308:1994;65-75.
25. Hunter T.C., Melancon S.B., Dallaire L., Taft S., Skopek T.R., Albertini R.J., O'Neill J.P. Germinal HPRT splice site mutation results in multiple RNA splicing products in T-lymphocyte cultures. Somat. Cell Mol. Genet. 22:1996;145-150.