Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent α4β1 integrin antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 19, 2001, Pages 2593-2596

  Duplantier, Allen J ^a   Beckius, Gretchen E ^a   Chambers, Robert J ^a   Chupak, Louis S ^a   Jenkinson, Teresa H ^a   Klein, Anne S ^a   Kraus, Kenneth G ^a   Kudlacz, Elizabeth M ^a   McKechney, Michael W ^a   Pettersson, Martin ^a   Whitney, Carrie A ^a   Milici, Anthony J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [1 [2 [3 METHOXY 4 (3,2 TOLYLUREIDO)PHENYL]ACETYLAMINO] 3 METHYLBUTYL]ISOXAZOL 5 YL]PROPIONIC ACID; ALPHA4BETA1 INTEGRIN ANTAGONIST; BIO 1211; INTEGRIN; ISOXAZOLYLPROPIONIC ACID DERIVATIVE; OXAZOLYLPROPIONIC ACID DERIVATIVE; THIAZOLYLPROPIONIC ACID DERIVATIVE; TR 14035; UNCLASSIFIED DRUG;

ALLERGY; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; MOUSE; NONHUMAN; REACTION ANALYSIS;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; HYPERSENSITIVITY; INTEGRIN ALPHA4BETA1; INTEGRINS; ISOXAZOLES; JURKAT CELLS; MICE; PROPIONATES; RECEPTORS, LYMPHOCYTE HOMING; STRUCTURE-ACTIVITY RELATIONSHIP;

LACTATE DEHYDROGENASE-ELEVATING VIRUS;

EID: 17944381032     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00511-X     Document Type: Article

References (21)