Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2517-2521

  Bianchi, Roberta ^a   Grohmann, Ursula ^a   Vacca, Carmine ^a   Belladonna, Maria L ^a   Fioretti, Maria C ^a   Puccetti, Paolo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 12; INTERLEUKIN 1BETA; RECOMBINANT INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOCRINE EFFECT; CELL TRANSFER; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; ANTIGENS, CD40; AUTOCRINE COMMUNICATION; DENDRITIC CELLS; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-2; LIGANDS; MALE; MICE; MICE, INBRED DBA; PEPTIDES; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033198044     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridges innate resistance and antigen specific adaptive immunity. Annu. Rev. Immunol. 13:251.
2. + T cells to enhance priming for IFN-γ production and diminishes IL-4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
3. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
4. Stout, R. D., and J. Suttles. 1996. The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today 17:487.
5. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cells stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
6. Shu, U., M. Kiniwa, C. Y. Wu, C. Maliszewski, N. Vezzio, J. Hakimi, M. Gately, and G. Delespesse. 1995. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
7. Kiener, P. A., P. Moran-Davis, B. M. Rankin, A. F. Wahl, A. Aruffo, and D. Hollenbaugh. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917.
8. + T cell contact-dependent activation of monocyte interleukin-1 synthesis. Eur. J. Immunol. 24:3148.
9. Bianchi, R., U. Grohmann, M. L. Belladonna, S. Silla, F. Fallarino, E. Ayroldi, M. C. Fioretti, and P. Puccetti. 1996 IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J. Immunol. 157:1589.
10. Grohmann, U., R. Bianchi, E. Ayroldi, M. L. Belladonna, D. Surace, M. C. Fioretti, and P. Puccetti. 1997. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state. J. Immunol. 158:3593.
11. + lymphocytes in the initiation of class I-restricled reactivity to a tumor/self peptide. Crit. Rev. Immunol. 18:87.
12. Grohmann, U., M. L. Belladonna, R. Bianchi, C. Orabona, E. Ayroldi, M. C. Fioretti, and P. Puccetti. 1998. IL-12 acts directly on DC to promote nuclear localization of NF-κB and primes DC for IL-12 production. Immunity 9:315.
13. - or helper peptides in priming for skin test reactivity to a P815AB-related peptide. Eur. J. Immunol. 25:2797.
14. + T-helper and a T-killer cell. Nature 393:474.
15. + T cell reactivity. Eur. J. Immunol. 24:1446.
16. Snijders, A., P. Kalinski, C. M. Hilkens, and M. L. Kapsenberg. 1998. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10:1593.
17. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
18. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
19. + T cells. J. Immunol. 154:5071.
20. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kämpgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741.
21. Neumann, M., G. Wohlleben, S. Chuvpilo, B. Kistler, T. Wirth, E. Serfling, and A. Schimpl. 1996. CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB. J. Immunol. 157:4862.
22. Bennett, S. R. M., F. R. Carbone, F. Karamalis, R. A. Flavell, J. F. A. P. Miller, and W. R. Heath. 1998. Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature 393:478.
23. Schoenberger, S. P., R. E. M. Toes, E. I. H. van der Voort, R. Offringa, and C. J. M. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480.
24. Lanzavecchia, A. 1998. Licence to kill. Nature 393:413.