Toll-like receptors: Dysregulation in vivo in patients with acute respiratory distress syndrome

Revista Alergia Mexico

Volumn 51, Issue 6, 2004, Pages 210-217

  Ramírez Cruz, Nora E ^a   Bernal, Carmen Maldonado ^a   Cuevas Urióstegui, María Luisa ^a   Castañón, Jorge ^a   Macías, Constantino López ^a   Isibasi, Armando ^a  

^a NONE

Author keywords

Human mononuclear cells; Inflammatory cytokines; Sepsis; Systemic inflammatory response syndrome; TLRs gene dysregulation

Indexed keywords

BETA ACTIN; CYTOKINE; DIATRIZOATE; FICOLL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR; INTERLEUKIN DERIVATIVE; MEMBRANE PROTEIN; MESSENGER RNA; TLR4 PROTEIN, HUMAN; TLR5 PROTEIN, HUMAN;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; IN VIVO STUDY; MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SEPSIS; SURVIVAL; AGED; BIOSYNTHESIS; BLOOD; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; MORTALITY; PROGNOSIS; PROSPECTIVE STUDY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

AGED; BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RECEPTORS, CELL SURFACE; RESPIRATORY DISTRESS SYNDROME, ADULT; RNA, MESSENGER; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TOLL-LIKE RECEPTOR 1; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 17844403259     PISSN: 00025151     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;3424:1334-49.
2. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149:818-24.
3. Gattinoni L, Bombino M, Pelosi P, et al. Lung structure and function in different stages of severe adult respiratory distress syndrome. JAMA 1994;271:1772-9.
4. Weinacker AB, Vaszar LT. Acute respiratory distress syndrome: physiology and new management strategies. Annu Rev Med 2001;52:221-37.
5. Artigas A, Bernard GR, Carlet J, et al. The American-European Consensus Conference on ARDS, part 2. Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory distress syndrome. Am J Respir Crit Care Med 1998;157:1332-47.
6. Jardin F, Fellahi JL, Beauchet A, et al. Improved prognosis of acute respiratory distress syndrome 15 years on. Intensive Care Med 1999;25:936-41.
7. Bersten AD, Edibam C, Hunt T, et al. Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian states. Am J Respir Crit Care Med 2002;165:443-8.
8. Hudson LD, Milberg JA, Anardi D, et al. Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 1995;151:293-301.
9. Tolley EA. Causal modeling in the activated host: implications for clinical investigation in sepsis and acute respiratory distress syndrome. Sepsis 2000;4:21-33.
10. Janeway CA Jr, Medzhitov R. Approaching the asymptote? Evolution and revolution in immunology. Cell 1997;9:295.
11. Le-Barillec K. Toll receptors: guardians of the immune system and effectors of septic shock. Adv Sepsis 2000;1:23-30.
12. Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 2001;29:S2-S6.
13. Underhill DM, Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 2002;14:103-10.
14. Medzhitov RJ, Janeway CA. Decoding the patterns of self and nonself by the innate immune system. Science 2002;296:298-300.
15. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol; 2002;20:197-216.
16. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-7.
17. Xu YJ, Tao XJ, Shen BJ, et al. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000;408:111-5.
18. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:25-734.
19. Bohrer H. Role of NFκB in the mortality of sepsis. J Clin Invest 1997;100:972-85.
20. Moine P, McIntyre R, Schwartz MD, et al. NF-kappaB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome. Shock 2000;13:85-91.
21. Schwartz MD, Moore EE, Moore FA, et al. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996;24:1285-92.
22. Fan J, Kapus A, Marsden PA, et al. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol 2002;168:5252-9.
23. Medvedev AE, Kopydlowski KM, Vogel SN. Inhibition of lipopolysaccharide- induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol 2000;164:5564-74.
24. Nomura F, Akashi S, Sakao Y, et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000;164:3476-9.
25. Hirschfeld M, Kirschning CJ, Schwandner R, et al. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J Immunol 1999;163:2382-6.
26. Kirschning CJ, Wesche H, Merrill AT, et al. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 1998;188:2091-7.
27. Ohashi K, Burkart V, Flohe S, et al. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000;164:558-61.
28. Vabulas RM, Ahmad-Nejad P, Ghose S, et al. HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 2002;277:15107-12.
29. Williams DL, Ha T, Li C, et al. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med 2003;31:1808-18.
30. Matzinger P. The danger model: a renewed sense of self. Science 2002;296:301-5.
31. Johnson GB, Brunn GJ, Tang AH, et al. Evolutionary clues to the functions of the Toll-like family as surveillance receptors. Trends Immunol 2003;24:19-24.
32. Asea A, Rehli M, Kabingu E, et al. Novel signal transduction pathway utilized extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 2002;277:15028-34.
33. Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191-5.