The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro

Leukemia

Volumn 15, Issue 1, 2001, Pages 112-120

  Horn, S ^a   Meyer, J ^a   Heukeshoven, J ^a   Fehse, B ^b   Schulze, C ^b   Li, S ^c   Frey, J ^c   Poll, S ^a   Stocking, C ^a   Jucker M ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c BIELEFELD UNIVERSITY   (Germany)

Author keywords

Proteolysis, acute myeloid leukemia; SHIP

Indexed keywords

BENZYLSULFONYL FLUORIDE; CYTOKINE RECEPTOR; ISOPROTEIN; PROTEINASE; SERINE PROTEINASE INHIBITOR; SYNAPTOJANIN; TRYPTOPHAN;

ACUTE GRANULOCYTIC LEUKEMIA; ALTERNATIVE RNA SPLICING; ARTICLE; B LYMPHOCYTE; BLOOD CELL; BONE MARROW CELL; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAST CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

EID: 17744386335     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401990     Document Type: Article

References (33)

1. Multiple Cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc
2. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
3. Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
4. Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
5. Targeted disruption of SHIP leads to hematopoietic perturbations, lung pathology, and a shortened life span
6. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
7. The SH2-Containing inositol polyphosphate 5-Phosphatase, SHIP, is expressed during hematopoesis and spermatogenesis
8. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood
9. Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by c-terminal truncation
10. Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP
11. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin
12. Effect of src infection on long-term marrow cultures: Increased self-renewal of hemopoietic progenitor cells without leukemia
13. Self renewal and differentiation of interleukin-3-independent multipotent stem cells are modulated by stromal cells and serum factors
14. Growth of factor-dependent hemopoietic precursor cell lines
15. Release of spleen focus-forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by Friend leukemia virus
16. Biochemical and biological properties of interleukin-3: A lymphokine mediating the differentiation of a lineage of cells which includes prothymocytes and mast-like cells
17. Carboxyl-truncated STAT5b is generated by a nucleus-associated serine protease in early hematopoietic progenitors
18. Selective immunoaffinity-based enrichment of CD34+ cells transduced with retroviral vectors containing an intracytoplasmatically truncated version of the human low-affinity nerve growth factor receptor (deltaLNGFR) gene
19. Heterogeneous expression of proto-oncogenes in Hodgkin's disease derived cell lines
20. Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease
21. Functional specificity of cytoplasmic and transmembrane tyrosine kinases: Identification of 130 and 75 kda substrates of c-fps/fes tyrosine kinase in macrophages
22. Identification of a new adapter protein that may link the common β subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase
23. Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with Shc after cytokine stimulation
24. Average and maximum charge states of arginine-containing dendrimer-like peptide ions formed by electrospray ionization
25. Rat insulin-degrading enzyme: Cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
26. A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development
27. Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis
28. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
29. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
30. A new protein containing an SH2 domain that inhibits JAK kinases
31. A family of cytokine-inducible inhibitors of signalling
32. Structure and function of a new STAT-induced STAT inhibitor
33. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FcgRIIB