Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3- carboxylic acid

Journal of Organic Chemistry

Volumn 70, Issue 9, 2005, Pages 3592-3601

  Chung, John Y L ^a   Cvetovich, Raymond ^a   Amato, Joseph ^a   McWilliams, J Christopher ^a   Reamer, Robert ^a   DiMichele, Lisa ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CHEMICAL BONDS; CHROMATOGRAPHIC ANALYSIS; COMPLEXATION; NEGATIVE IONS; SAPONIFICATION; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

CYCLIZATION; ENANTIOSELECTIVITY; EPIMERIZATION; OPTICAL PURITY;

NITROGEN COMPOUNDS;

(3,4) 1 TERT BUTYL 4(2,4 DIFLUOROPHENYL)PYRROLIDIN 3 CARBOXYLIC ACID; 2 CHLORO 1(2,4 DIFLUOROPHENYL)ETHANONE; ALPHA CHLOROHYDRIN; BENZENE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHLORINE DERIVATIVE; DIETHYL CHLOROPHOSPHATE; LITHIUM DERIVATIVE; LITHIUM HEXAMETHYLDISILAZIDE; PHOSPHATE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; ASYMMETRIC SYNTHESIS; CHEMICAL ANALYSIS; CHROMATOGRAPHY; CYCLIZATION; DRUG SYNTHESIS; REDUCTION;

EID: 17744384724     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050178+     Document Type: Article

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