Adenoviral-mediated transduction of human pancreatic islets: Importance of adenoviral genome for cell viability and association with a deficient antiviral response

Endocrinology

Volumn 146, Issue 5, 2005, Pages 2406-2414

  Barbu, Andreea R ^a,b   Akusjärvi, Göran ^a   Welsh, Nils ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CYTOTOXICITY; GENE DELETION; GENE THERAPY; GENETIC TRANSDUCTION; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION; VIRUS CONCENTRATION; VIRUS GENOME;

ADENOSINE DIPHOSPHATE; ADENOVIRIDAE; ADENOVIRUS E1 PROTEINS; ADENOVIRUS E3 PROTEINS; ADENOVIRUS E4 PROTEINS; ANIMALS; ANTIVIRAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; GENE DELETION; GENETIC VECTORS; HUMANS; INTERFERON-ALPHA; ISLETS OF LANGERHANS; NECROSIS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 17744376005     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-1667     Document Type: Article

References (52)

1. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman, NM, Rajotte RV 2000 Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238
2. Rabinovitch A, Suarez-Pizon W, Strynadka K, Ju Q, Edelstein D, Brownlee M, Korbutt GS, Rayotte RV 1999 Transfection of human pancreatic islets with an anti-apoptotic gene (Bcl-2) protects β-cells from cytokine-induced destruction. Diabetes 48:1223-1229
3. Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD 1999 Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1β-induced β-cell impairment and activation of islet cell apoptosis in vitro. Diabetes 48:1730-1736
4. Taniguchi H, Yamato E, Tashiro F, Ikegami H, Oghihara T, Miyazaki J 2003 β-Cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas. Gene Ther 10:15-23
5. Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF 2000 Hepatocyte growth factor overexpression in the islet of transgenic mice increases β cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 275:1226-1232
6. Hui H, Wright C, Perfetti G 2001 Glucagon-lrke peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50:785-796
7. Bartlett R, Denis M, Inverardi L, Ricordi C 1998 Introduction of immunomodulatory genes into isolated pancreatic islets via biolistic particle bombardment. Transplant Proc 30:452-459
8. Lakey JRT, Young ATL, Pardue D, Calvin S, Albertson TE, Jacobson L, Cavanagh TJ 2001 Nonviral transfection of intact pancreatic islets. Cell Transplant 10:697-708
9. Ju Q, Edelstein D, Brendel MD, Brandhorst D, Bretzel RG, Brownlee M 1998 Transduction of non-dividing adult human pancreatic β cells by an integrating lentiviral vector. Diabetologia 41:736-739
10. Flotte T, Agarwal A, Wang J, Song S, Fenjves ES, Inverardi L, Chesnut K, Afione S, Loiler S, Wasserfall C, Kapturczak M, Ellis T, Nick H, Atkinson M 2001 Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes 50:515-520
11. Bilbao G, Contreras JL, Dmitriev I, Smyth CA, Jenkins S, Eckhoff D, Thomas F, Thomas J, Curiel DT 2002 Genetically modified adenovirus vector containing an RDG peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets. Am J Transplant 2:237-243
12. Barbu AR, Akusjarvi G, Welsh N 2002 Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression. Mol Med 8:733-741
13. Braithwaite AW, Russell IA 2001 Induction of cell death by adenoviruses. Apoptosis 6:359-370
14. Tollefson AE, Scaria A, Hermiston TW, Ryerse JS, Wold LJ, Wold WSM 1996 The adenovirus death protein (E3-11.6K) is required at very late stages of transduction for efficient cell lysis and release of adenovirus from transduced cells. J Virol 70:2296-2306
15. Guidotti LG, Chisari FV 2000 Cytokine-mediated control of viral transductions. Virol 273:221-227
16. Pujol-Borrel R, Todd I, Doshi M, Gray D, Feldman M, Bottazzo GF 1986 Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol 65:128-139
17. Vives-Pi M, Armengol MP, Alcalde L, Costa M, Somoza N, Vargas F, Jaraquemada D, Pujol-Borrel R 1996 Expression of transporter associated with antigen specific processing-1 in the endocrine cells of human pancreatic islets: effects of cytokines and evidence of hyperexpression in IDDM. Diabetes 45:779-788
18. Andersson A 1978 Isolated mouse pancreatic islets in culture: effects of serum and different culture media on the insulin production of the islets. Diabetologia 14:397-404
19. Molin M, Shoshan MC, Öhman-Forslund K, Linder S, Akusjärvi G 1998 Two novel adenovirus systems permitting regulated protein expression in gene transfer experiments. J Virol 72:8358-8361
20. Gossen M, Bujard H 1992 Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 89:5547-5551
21. Weiden MD, Ginsberg HS 1994 Deletion of the E4 region of the genome produces adenovirus DNA concatemers. Proc Natl Acad Sci USA 91:153-157
22. He T-C, Zhou S, Da Costa LT, Yu J, Kinzler KW, Vogelstein B 1998 A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514
23. Bhat BM, Wold WS 1986 Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive transduction by RNA-processing mutants. J Virol 60:54-63
24. Saldeen J, Curiel DT, Eizirik DL, Andersson A, Strandell E, Buschard K, Welsh N 1996 Efficient gene transfer to dispersed human pancreatic islet cells in vitro using adenovirus-polylysine/DNA complexes or polycationic liposomes. Diabetes 45:1197-1203
25. Linne T, Jornvall H, Philipson L 1977 Purification and characterization of the phosphorylated DNA-binding protein from adenovirus-type-2-transduced cells. Eur J Biochem 76:481-490
26. Gibson UE, Heid CA, Williams PM 1996 A novel method for real time quantitative RT-PCR. Genome Res 6:995-1001
27. Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvenga S, Trimarchi F, Ehrhart-Bornstein M 2002 Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural transductions and gene therapy. Proc Natl Acad Sci USA 99:7484-7489
28. Horwitz MS 2001 Adenovirus immunoregulatory genes and their cellular targets. Virology 279:1-8
29. Putzer B, Stiewe T, Parssanedjad K, Rega S, Esche H 2000 E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products. Cell Death Differ 7:177-188
30. Marcellus RC, Teodoro JG, Wu T, Brough DE, Ketner G, Shore GC, Branton PE 1996 Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis. J Virol 70:6207-6215
31. Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin W, Conaway R, Conaway JW, Branton PE 2001 Degradation of p53 by adenovirus E4 orf6 and E1B 55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes 15:3104-3117
32. Routes JM, Ryan S, Clase A, Miura T, Kuhl A, Potter TA, Cook JL 2000 Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL). J Immunol 165:4522-4527
33. Lesokhin AM, Delgado-Lopez F, Horwitz MS 2002 Inhibition of chemokines expression by adenovirus early region three (E3) genes. J Virol 76:8236-8243
34. Krajcsi P, DimitrovT, Hermiston TW, Tollefson AE, Ranheim TS, VandePol SB, Stephenson AH, Wold WS 1996 The adenovirus E3-14.7K protein and the E3-10.4/14.5K complex of proteins, which independently inhibit tumor necrosis factor (TNF)-induced apoptosis, also independently inhibit TNF-induced release of arachidonic acid. J Virol 70:4904-4913
35. Zhang F, Cheng J, Hackett NR, Lam G, Shido K, Pergolizzi R, Jin DK, Crystal RG, Rafii S 2003 Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the VE-cadherin/Akt signaling pathway. J Biol Chem 279:11760-11766
36. Russell WC 2000 update on adenovirus and its vectors. J Gen Virol 81:2573-2604
37. Nevins JR 1981 Mechanisms of activation of early viral transcription by the adenovirus E1A gene product. Cell 26:213-220
38. White E, Cipriani R 1989 Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene. Proc Natl Acad Sci USA 86:9886-9890
39. Lutz P, Rosa-Calatrava M, Kedinger C 1997 The product of the adenovirus intermediate gene IX is a transcriptional activator. J Virol 71:5102-5109
40. Sargent KL, Meulenbroek RA, Parks RJ 2004 Activation of adenoviral gene expression by protein IX is not required for efficient virus replication. J Virol 78:5032-5037
41. Bach JF 1994 Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 15:516-542
42. Yoon JW, Jun HS, Santamaria P 1998 Cellular and molecular mechanisms for the initiation and progression of β-cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 27:109-122
43. Flodström M, Maday A, Balakrishna D, Malo Cleary M, Yoshimura A, Sarvetnick N 2002 Target cell defence prevents the development of diabetes after viral transduction. Nature Immunol 3:373-382
44. Stewart TA 2003 Neutralizing interferon α as a therapeutic approach to autoimmune diseases. Cytokine Growth Factor Rev 14:139-154
45. Goodbourn S, Didcock L, Randall RE 2000 Interferons: cell signaling, immune modulation, antiviral responses and virus contrameasures. J Gen Virol 81:2341-2364
46. Kalvakolanu DVR, Bandyopadhyay SK, Harter ML, Sen GC 1991 Inhibition of the interferon inducible gene expression by adenovirus E1A proteins: block in the transcriptional complex formation. Proc Natl Acad Sci USA 88:7459-7463
47. Taniguchi T, Takaoka A 2002 The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 14:111-116
48. Der SD, Zhou A, Williams BRG, Silverman RH 1998 Identification of genes differentially regulated by the interferon α, β or γ using oligonucleotide arrays. Proc Natl Acad Sci USA 95:15623-15628
49. Dong Z, Yan, X, Fidler IJ 1997 Neutralization of endogenous interferon-β increases the efficiency of adenoviral vector-mediated gene transduction. J Interferon Cytokine Res 17:401-407
50. Vilquin JT, Guerette B, Kinoshita I, Roy B, Goulet M, Gravel C, Roy R, Tremblay JP 1995 FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer. Hum Gen Ther 6:1391-1401
51. Eizirik DL, Pipeleers DG, Ling Z, Welsh N, Hellerstrom C, Andersson A 1994 Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc Natl Acad Sci USA 91:9253-9256
52. Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodstrom M, Mello MA, Andersson A, Pipeleers DG, Hellerstrom C 1995 Differences in the expression of heat shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin dependent diabetes mellitus. Mol Med 1:806-820