Preparation and in vitro characterization of a semi-solid dispersion of flurbiprofen with Gelucire 44/14 and Labrasol

Pharmazie

Volumn 60, Issue 4, 2005, Pages 288-293

  Soliman, M S ^a   Khan, Mansoor A ^a,b  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Life Sciences Building 64 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLURBIPROFEN; GELUCIRE; LABRASOL;

ARTICLE; BIOAVAILABILITY; DISPERSION; DRUG ABSORPTION; DRUG DOSAGE FORM; DRUG SYNTHESIS; GEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTESTINE ULCER; PARTICLE SIZE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CAPSULES; CHEMISTRY, PHYSICAL; EMULSIONS; EXCIPIENTS; FLURBIPROFEN; GELATIN; NEPHELOMETRY AND TURBIDIMETRY; ORGANIC CHEMICALS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 17644421075     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Aungst BJ, Nguyen NH, Rogers NJ, Rowe SM, Hussain MA, White SJ, Shum L (1997) Amphiphilic vehicles improve the oral bioavailability of a poorly soluble HIV protease inhibitor at high doses. Int J Pharm 156: 79-88.
2. Barker SA, Yap SP, Yuen KH, McCoy CP, Murphy JR, Craig DQM (2003) An investigations into the structure and bioavailability of α-tocopherol dispersions in Gelucire 44/14. J Control Release 91: 477-488.
3. Baykara T, Yuksel N (1991) The preparation of prolonged action formulations in the form of semi solid matrix into hard gelatin capsules. Drug Dev Ind Pharm 17: 1215-1227.
4. Bhattacharyya M, Basu SK, Gupta B K, Ghosal SC, Mandal SC, Chattaraj SS (1993) Formulation and in vitro-in vivo characterization of solid dispersions of piroxicam. Drug Dev Ind Pharm 19: 29-35.
5. Brogden RN, Heal RC, Speihgt TM, Avery GS (1979) Drugs 18: 417.
6. Chiou WL, Riegelman S (1971) Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60: 1281.
7. Craig DQM (1995) The use of glycerides as controlled release matrices, in: Karsa, D.R., Stephenson, R. A., (Eds), Excipients and Delivery Systems for Pharmaceutical Formulations, Royal Society of Chemistry, Cambridge pp. 148-174.
8. Crison JR, Lipka E, Kim JS, Amidon GL (1997) Lipid-filled hard gelatin capsules as novel drug delivery systems with application to nifedipine. Bull Tech Gattefosse 90: 71-73.
9. Dennis AB, Farr SJ, Kellaway IW, Taylor R, Davidson R (1990) In vivo evaluation of rapid release and sustained release Gelucire capsule formulations. Int J Pharm 65: 85-100.
10. Dordunoo SK, Ford JL, Rubinstein MH (1991) Preformulation studies on solid dispersions containing triamterene or temazepam in polyethylene glycols or Gelucire 44/14 for liquid filling of hard gelatin capsules. Drug Dev Ind Pharm 17: 1685-1713.
11. El Massik MA, Abdallah OY, Galal S, Daabis NA, (2003) Semi-solid matrix filled capsules: An approach to improve dissolution stability of phenytoin sodium formulation. Drug Dev Ind Pharm 5: 531-543.
12. th Edition., Council of Europe, Strasbourg pp. 804, 1449.
13. Fernandez M, Margarit MV, Rodriguez IC, Crezo A (1993) Dissolution kinetics of piroxicam in solid dispersions with polyethylene glycol 4000. Int J Pharm 98: 29-35.
14. st Edition.
15. Gershanik T, Benita S (2000) Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 50: 179-188.
16. Green JT, Evans BK, Rhodes J, Thomas GAO, Ranshaw C, Feyerabend C, Russell MAH (1999) An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics. Br J Clin Pharmacol 48: 485-493.
17. Humberstone AJ, Charman WN (1997) Lipid-based vehicles for oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev 25: 103-128.
18. Itoh K, Tozuka Y, Oguchi T, Yamamoto K (2002) Improvement of physicochemical properties of N-4472 Part I. Formulation design by using self-microemulsifying system. Int J Pharm 238: 153-160.
19. Kimura E, Bersani-Amado CA, Sudo LS, Santos SRJ, Oga S (1997) Pharmacokinetic profile of piroxicam β-cyclodextrin in rat plasma and lymph. Gen Pharmacol 28: 695-698.
20. MacGregor KJ, Embleton JK, Lacy JE, Perry EA, Solomon LJ, Seager H, Pouton CW (1997) Influence of lipolysis on drug absorption from the gastro-intestinal tract. Adv Drug Deliv Rev 25: 33-46.
21. Masaki O, Teruko I, Kaneto U (1982) Enhanced oral bioavailability of anti-inflammatory drug flurbiprofen in rabbits by tri-o-methyl β-cyclodextrin complexation. J Pharm Dyn 5: 1027-1029.
22. Nazzal S, Smalyukh II, Lavrentovich OD, Khan M (2002) Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of emulsion formation. Int J Pharm 235: 247-265.
23. Nilufer Y, Aysegul K, Yalcin O, Ayhan S, Sibel AO, Tamer B (2003) Enhanced bioavailability of piroxicam using Gelucire 44/14 and Labrasol: in vitro and in vivo evaluation. Eur J Pharm Biopharm 56: 453-459.
24. Nurzalina K, Duncan QMC (2003) The influence of drug incorporation on the structure and release properties of solid dispersions in lipid matrices. J Control Release 93: 355-368.
25. Pouton CW (1985) Self-emulsifying drug delivery systems: Assessment of the efficiency of emulsification. Int J Pharm 27: 335-348.
26. Pozzi F, Longo A, Lazzarini C, Carenzi A (1991) Formulations of ubide-carenone with improved bioavailability. Eur J Pharm Biopharm 37: 243-246.
27. Rosario P, Marinella F, Giovanni P (2002) Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug polymer interactions. AAPS Pharm Sci Tech 3 (2) article 10.
28. Seo A, Holm P, Kristensen HG, Schaefer T (2003) The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer. Int J Pharm 259: 161-171.
29. Serajuddin ATM, Sheen PC, Mufson D, Bernstein DF, Augustine MA (1988) Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions. J Pharm Sci 77: 414-417.
30. Sheen PC, Kim SI, Petillo JJ, Serajudden ATM (1991) Bioavailability of a poorly water-soluble drug from tablet and solid dispersions in humans. J Pharm Sci 80: 712-714.
31. Tantishaiyakul V, Kaewnopparat N, Ingkatawornwong S (1999) Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. Int J Pharm 181: 143-151.