An oral formulation of nicotine for release and absorption in the colon: Its development and pharmacokinetics

British Journal of Clinical Pharmacology

Volumn 48, Issue 4, 1999, Pages 485-493

  Green, J T ^a   Evans, B K ^b   Rhodes, J ^a   Thomas, G A O ^a   Ranshaw, C ^b   Feyerabend, C ^c   Russell, M A H ^d  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c New Cross Hospital ^*  (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Carbomers; Drug formulation; Nicotine; Ulcerative colitis

Indexed keywords

CARBOMER; EUDRAGIT; GELUCIRE; NICOTINE;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; DRUG TOLERABILITY; FEMALE; GAS LIQUID CHROMATOGRAPHY; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; INTESTINE TRANSIT TIME; MALE; NAUSEA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ABSORPTION; ACRYLIC RESINS; ADMINISTRATION, ORAL; ADULT; CAPSULES; CHEMISTRY, PHARMACEUTICAL; COLITIS, ULCERATIVE; COTININE; DELAYED-ACTION PREPARATIONS; FEMALE; GANGLIONIC STIMULANTS; GLYCERIDES; HUMANS; MALE; NICOTINE; POLYVINYLS; PROTEASE INHIBITORS; TIME FACTORS;

EID: 0032865770     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00057.x     Document Type: Article

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