Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells

Pharmaceutical Research

Volumn 21, Issue 12, 2004, Pages 2253-2260

  Nielsen, Hanne Mørck ^a,b   Aemisegger, Caroline ^a   Burmeister, Gerd ^c   Schuchter, Ursula ^d   Gander, Bruno ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ASAT AG   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Aminolevulinic acid uptake; Endocytosis; MCF 7 cells; Oil in water emulsions; Photodynamic diagnosis and therapy; Protoporphyrin IX

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG METABOLISM; DRUG UPTAKE; EMULSION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INCUBATION TIME; PH; PRIORITY JOURNAL; TEMPERATURE;

AMINOLEVULINIC ACID; EMULSIONS; ENDOCYTOSIS; HUMANS; OILS; PROTOPORPHYRINS; TUMOR CELLS, CULTURED; WATER;

EID: 17644420748     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-7678-2     Document Type: Article

References (32)

1. K. Lang, P. Lehmann, K. Bolsen, T. Ruzicka, and C. Fritsch. Aminolevulinic acid: pharmacological profile and clinical indication. Expert Opin. Investig. Drugs 10:1139-1156 (2001).
2. E. L. Taylor and S. B. Brown. The advantages of aminolevulinic acid photodynamic therapy in dermatology. J. Dermatolog. Treat. 13(Suppl 1):S3-11 (2002).
3. R. M. Szeimies, M. Landthaler, and S. Karrer. Non-oncologic indications for ALA-PDT. J. Dermatolog. Treat. 13(Suppl 1):S13-S18 (2002).
4. A. Bunke, O. Zerbe, H. Schmid, G. Burmeister, H. P. Merkle, and B. Gander. Degradation mechanism and stability of 5-aminolevulinic acid. J. Pharm. Sci. 89:1335-1341 (2000).
5. B. Elfsson, I. Wallin, S. Eksborg, K. Rudaeus, A. M. Ros, and H. Ehrsson. Stability of 5-aminolevulinic acid in aqueous solution. Eur. J. Pharm. Sci. 7:87-91 (1999).
6. M. Novo, G. Huttmann, and H. Diddens. Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours. J. Photochem. Photobiol. B 34:143-148 (1996).
7. A. Casas, C. Perotti, M. Saccoliti, P. Sacca, H. Fukuda, and A. M. Batlle. ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures. Br. J. Cancer 86:837-842 (2002).
8. Y. Ninomiya, Y. Itoh, S. Tajima, and A. Ishibashi. In vitro and in vivo expression of protoporphyrin IX induced by lipophilic 5-aminolevulinic acid derivatives. J. Dermatol. Sci. 27:114-120 (2001).
9. J. Morgan and A. R. Oseroff. Mitochondria-based photodynamic anti-cancer therapy. Adv. Drug Deliv. Rev. 49:71-86 (2001).
10. V. Vonarx, S. Eleouet, J. Carre, P. Ioss, A. Gouyette, A. M. Leray, C. Merle, Y. Lajat, and T. Patrice. Potential efficacy of a delta 5-aminolevulinic acid bioadhesive gel formulation for the photodynamic treatment of lesions of the gastrointestinal tract in mice. J. Pharm. Pharmacol. 49:652-656 (1997).
11. S. Lieb, R. M. Szeimies, and G. Lee. Self-adhesive thin films for topical delivery of 5-aminolevulinic acid. Eur. J. Pharm. Biopharm. 53:99-106 (2002).
12. A. F. Hurlimann, G. Hanggi, and R. G. Panizzon. Photodynamic therapy of superficial basal cell carcinomas using topical 5-aminolevulinic acid in a nanocolloid lotion. Dermatology 197:248-254 (1998).
13. K. Svanberg, T. Andersson, D. Killander, I. Wang, U. Stenram, S. Andersson-Engels, R. Berg, J. Johansson, and S. Svanberg. Photodynamic therapy of non-melanoma malignant tumours of the skin using topical delta-amino levulinic acid sensitization and laser irradiation. Br. J. Dermatol. 130:743-751 (1994).
14. A. Casas, H. Fukuda, G. Di Venosa, and A. M. Batlle. The influence of the vehicle on the synthesis of porphyrins after topical application of 5-aminolaevulinic acid. Implications in cutaneous photodynamic sensitization. Br. J. Dermatol. 143:564-572 (2000).
15. F. Doring, J. Walter, J. Will, M. Focking, M. Boll, S. Amasheh, W. Clauss, and H. Daniel. Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J. Clin. Invest. 101:2761-2767 (1998).
16. D.A. Groneberg, F. Doring, S. Theis, M. Nickolaus, A. Fischer, and H. Daniel. Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am. J. Physiol. Endocrinol. Metab. 282:E1172-E1179 (2002).
17. J. Neumann and M. Brandsch. Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct. J. Pharmacol. Exp. Ther. 305:219-224 (2003).
18. M. Irie, T. Terada, K. Sawada, H. Saito, and K. Inui. Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells. J. Pharmacol. Exp. Ther. 298:711-717 (2001).
19. M. Bermudez-Moretti, S. Correa-Garcia, C. Perotti, A. Batlle, and A. Casas. Delta-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters. Br. J. Cancer 87:471-474 (2002).
20. S. Correa-Garcia, A. Casas, C. Perotti, A. Batlle, and M. Bermudez-Moretti. Mechanistic studies on delta-aminolevulinic acid uptake and efflux in a mammary adenocarcinoma cell line. Br. J. Cancer 89:173-177 (2003).
21. E. Rud, O. Gederaas, A. Hogset, and K. Berg. 5-aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochem. Photobiol. 71:640-647 (2000).
22. H. D. Soule, J. Vazguez, A. Long, S. Albert, and M. Brennan. A human cell line from a pleural effusion derived from a breast carcinoma. J. Natl. Cancer Inst. 51:1409-1416 (1973).
23. L. Wyld, M. Tomlinson, M. W. Reed, and N. J. Brown. Aminolaevulinic acid-induced photodynamic therapy: cellular responses to glucose starvation. Br. J. Cancer 86:1343-1347 (2002).
24. J. Jacobsen, M. Pedersen, and M. R. Rassing. TR146 cells as a model for human buccal epithelium: II. Optimisation and use of a cellular sensitivity MTS/PMS assay. Int. J. Pharm. 141:217-225 (1996).
25. H. U. Eirheim, C. Bundgaard, and H. M. Nielsen. Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate. Toxicol. In Vitro 18:649-657 (2004).
26. J. Moan, K. Berg, O. B. Gadmar, V. Iani, L. Ma, and P. Juzenas. The temperature dependence of protoporphyrin IX production in cells and tissues. Photochem. Photobiol. 70:669-673 (1999).
27. M. C. Aalders, N. van der Vange, W. M. Star, and H. J. Sterenborg. A mathematical evaluation of dose-dependent PpIX fluorescence kinetics in vivo. Photochem. Photobiol. 74:311-317 (2001).
28. O. Bourdon, V. Mosqueira, P. Legrand, and J. Biais. A comparative study of the cellular uptake, localization and phototoxicity of meta- tetra(hydroxyphenyl) chlorin encapsulated in surface-modified submicronic oil/water carriers in HT29 tumor cells. J. Photochem. Photobiol. B 55:164-171 (2000).
29. F. S. De Rosa, J. M. Marchetti, J. A. Thomazini, A. C. Tedesco, and M. V. Bentley. A vehicle for photodynamic therapy of skin cancer: influence of dimethylsulphoxide on 5-aminolevulinic acid in vitro cutaneous permeation and in vivo protoporphyrin IX accumulation determined by confocal microscopy. J. Control. ReI. 65:359-366 (2000).
30. S. L. Hussey and B. R. Peterson. Efficient delivery of streptavidin to mammalian cells: clathrin-mediated endocytosis regulated by a synthetic ligand. J. Am. Chem. Soc. 124:6265-6273 (2002).
31. J. S. Choi, K. R. Kim, D. W. Ahn, and Y. S. Park. Cadmium inhibits albumin endocytosis in opossum kidney epithelial cells. Toxicol. Appl. Pharmacol. 161:146-152 (1999).
32. C. A. Casey, R. L. Wiegert, and D. J. Tuma. Effect of hyperosmolarity on both receptor-mediated and fluid-phase endocytosis in ethanol-fed animals. Biochem. Pharmacol. 49:1117-1123 (1995).