ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures

British Journal of Cancer

Volumn 86, Issue 5, 2002, Pages 837-842

  Casas, A ^a   Perotti, C ^a   Saccoliti, M ^b   Sacca, P ^a   Fukuda, H ^a   Batlle, A M Del C ^a  

^a Centro de Investigaciones sobre Porfirinas y Porfirias   (Argentina)

^b HOSPITAL DURAND   (Argentina)

Author keywords

ALA; ALA derivatives; Aminolevulinic acid; Hexyl ALA; Liposomes; PDT; Photodynamic therapy

Indexed keywords

AMINOLEVULINIC ACID; LIPOSOME; PORPHYRIN; PRODRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL MEMBRANE; CONTROLLED STUDY; DRUG FORMULATION; ENCAPSULATION; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; LASER; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; ORGAN CULTURE; PHOSPHOLIPID VESICLE; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; TUMOR CELL CULTURE;

AMINOLEVULINIC ACID; ANIMALS; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; MITOCHONDRIA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; TUMOR CELLS, CULTURED;

EID: 0037017839     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600144     Document Type: Article

References (23)

1. Comparative effect of ALA derivatives on protoporphyrin IX production in human and rat skin organ cultures
2. Photosensitisation and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy
3. Biosynthesis and photodynamic therapy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells
4. Photoradiation therapy for the treatment of malignant tumors
5. Photodynamic therapy
6. Porphyrins and metalloporphyrins
7. Photodynamic action of endogenously syntesized porphyrins from aminolevulinic acid, using a new model for assaying the effectiveness of tumoral cell killing
8. Tumor-localizing properties of porphyrins In vitro studies using the porphyrin precursor, aminoevulinic acid, in free and liposome encapsulated forms
9. Tumour-localizing properties of porphyrins In vivo studies using free and liposome encapsulated aminolevulinic acid
10. Use of 5-aminolevulinic acid esters to improve photodynamic therapy on cells in culture
11. Liposomes disposition in vivo. V. Liposome stability in plasma and implications for drug carrier function
12. A mechanistic study of cellular photodestruction with 5-aminolevulinic acid-induced porphyrin
13. Photodynamic therapy with endogenous protoporphyrin IX: Basic principles and present clinical experience
14. Prodrugs for 5-aminolevulinic acid for photodynamic therapy
15. Derivatives of 5-aminolevulinic acid for photodynamic therapy: Enzymatic conversion into protoporphyrin
16. Photodetection of early human bladder cancer based on the fluorescence of 5-aminolevulinic acid hexylester-induced protoporphyrin IX: A pilot study
17. Application of liposomes in pharmacology and medicine
18. Lipid-cell interactions. A novel mechanism of transfer of liposome-entrapped substances into cells
19. The occurrence and determination of 5-aminolevulinic acid and porphobilinogen in urine
20. Further studies on the hystamine metabolism in the M2 adenocarcinoma
21. Preparation of 5-aminolevulinic alkyl esters as herbicides
22. Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: Differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum