Mechanisms leading to progression of chronic renal injury: The interstitium

Drug Discovery Today: Disease Mechanisms

Volumn 1, Issue 1, 2004, Pages 65-72

  Rossini, Michele ^a   Fogo, Agnes B ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTERIOSCLEROSIS; CELL DIFFERENTIATION; CHRONIC DISEASE; DISEASE COURSE; EXTRACELLULAR MATRIX; GLOMERULOSCLEROSIS; HUMAN; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY INTERSTITIUM; MACROPHAGE ACTIVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REVIEW; UPREGULATION;

EID: 17644410911     PISSN: 17406765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmec.2004.05.002     Document Type: Review

References (28)

1. Schainuck, L.I. et al. (1970) Structural-functional correlations in renal disease. II. The correlations, Hum. Pathol. 1, 631-641
2. Benigni, A. Remuzzi, G. (2001) How renal cytokines and growth factors contribute to renal disease progression, Am J. Kidney Dis. 37 (Suppl 2), S21-S24
3. Eddy, A.A. (2001) Molecular basis of renal fibrosis, Pediatr. Nephrol. 15 (2000), 290-301
4. Peterson, J.C. et al. (1995) Blood pressure control, proteinuria, and the progression of renal disease. The Modification of Diet in Renal Disease Study, Ann. Intern. Med. 123, 724-762
5. Ruggenenti, P. et al. on behalf of the GISEN group (1997) Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy, Lancet 349, 1857-1863
6. Remuzzi, G. Bertani, T. (1998) Phatophysiology of progressive nephropathies, N. Engl. J. Med. 339, 1448-1456
7. Song, E. et al. (2002) Early application of Met-RANTES ameliorates chronic allograft nephropathy, Kidney Int. 61, 676-685
8. Shimizu, H. et al. (2003) Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria, J. Am Soc. Nephrol. 14, 1496-1505
9. Zoja, C. et al. (2003) Proteinuria and phenotypic change of proximal tubular cells, J. Am Soc. Nephrol. 14, S36-S41
10. 2 through a PKC dependent pathway, J. Am. Soc. Nephrol. 13, 1179-1189
11. Cao, Z. Cooper, M.E. (2001) Role of angiotensin II in tubulointerstitial injury, Semin. Nephrol. 21, 554-562
12. Brown, N.J. et al. (2002) The renin-angiotensin-aldosterone system and fibrinolysis in progressive renal disease, Semin. Nephrol. 22, 399-406
13. Gomez-Garre, D. et al. (2001) Activation of NF-kB in tubular epithelial cells of rats with intense proteinuria. Role of angiotensin II and endothelin-1, Hypertension 37, 1171-1178
14. Nangaku, M. et al. (2002) C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys, J. Am. Soc. Nephrol. 13, 928-936
15. Eddy, A.A. (2001) Role of cellular infiltrates in response to proteinuria, Am. J. Kidney Dis. 37 (Suppl 2), S25-S29
16. Sharma, K. Ziyadeh, F.N. (1994) The emerging role of transforming growth factor-β in kidney disease, Am. J. Physiol. 266, F829-F842
17. Munger, J.S. et al. (1999) The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis, Cell 96, 319-328
18. -/- mice, Am. J. Pathol. 163, 1261-1273
19. Nishida, M. et al. (2002) Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis, J. Clin. Invest. 110, 1859-1868
20. Eddy, A.A. (2002) Plasminogen activator inhibitor-1 and the kidney, Am. J. Physiol. Renal. Physiol. 283, F209-F220
21. Schanstra, J .P. et al. (2002) In vivo bradykinin B2 receptor activation reduces renal fibrosis, J. Clin. Invest. 110, 371-379
22. Kim, S.I. et al. (2000) Effect of lovastatin on small GTP binding proteins and TGF-β1 and fibronectin expression, Kidney Int. 58 (Suppl 77), S88-S92
23. Essig, M. et al. (2000) Lovastatin modulates in vivo and in vitro the plasminogen activator/plasmin system of rat proximal tubular cells: role of geranylgeranylation and Rho proteins, J. Am. Soc. Nephrol. 9 (1998), 1377-1388
24. Iwano, M. et al. (2002) Evidence that fibroblasts derive from epithelium during tissue fibrosis, J. Clin. Invest. 110, 341-350
25. Katz, A. et al. (2002) An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients, Kidney Int. 61, 2058-2066
26. Li, Y. et al. (2003) Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis, J. Clin. Invest. 112, 503-516
27. Kang, D.H. Johnson, R.J. (2003) Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis, Curr. Opin. Nephrol. Hypertens. 12, 43-49
28. Fried, L.F. et al. (2001) Effect of lipid reduction on the progression of renal disease: A meta-analysis, Kidney Int. 59, 260-269