Perivascular T cells are infected with HTLV-I in the spinal cord lesions with HTLV-I-associated myelopathy/tropical spastic paraparesis: Double staining of immunohistochemistry and polymerase chain reaction in situ hybridization

Acta Neuropathologica

Volumn 96, Issue 4, 1998, Pages 340-346

  Matsuoka, E ^a   Takenouchi, N ^a   Hashimoto, K ^a   Kashio, N ^a   Moritoyo, T ^a   Higuchi, I ^a   Isashiki, Y ^a   Sato, E ^a   Osame, M ^a   Izumo, S ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Double staining; Fresh frozen sections; HTLV I associated myelopathy tropical spastic paraparesis; Immunohistochemistry; Polymerase chain reaction in situ hybridization

Indexed keywords

ANTIBODY; VIRUS DNA;

ADULT; AGED; ARTICLE; AUTOPSY; CASE REPORT; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; FROZEN SECTION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROPHAGE; MALE; PARENCHYMA; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPASTIC PARAPLEGIA; SPINAL CORD; SPINAL CORD DISEASE; SPINAL CORD LESION; T LYMPHOCYTE; VASCULARIZATION;

AGED; DELTARETROVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; PERICYTES; POLYMERASE CHAIN REACTION; PROVIRUSES; SILVER; SPINAL CORD; STAINING AND LABELING; T-LYMPHOCYTES;

EID: 0031659293     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050903     Document Type: Article

References (33)

1. Akizuki S, Nakazato O, Higuchi Y, Tanabe K, Setoguchi M, Yoshida S, Miyazaki Y, Yamamoto S, Sudou S, Sannomiya K, Okajima T (1987) Necropsy findings in HTLV-I associated myelopathy. Lancet I: 156-157
2. Aksamit A (1993) Nonradioactive in situ hybridization in progressive multifocal leukoencephalopathy. Mayo Clin Proc 68: 899-910
3. Bhigjee AI, Wiley CA, Wachsman W, Amenomori T, Pirie D, Bill PLA, Windsor I (1991) HTLV-I-associated myelopathy: clinicopathologic correlation with localization of provirus to spinal cord. Neurology 41: 1990-1992
4. Boshoff C, Schultz TF, Kennedy MM, Graham AK, Fisher C, Thomas A, McGee J, Weiss RA, O'Leary JJ (1995) Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 12: 1274-1278
5. Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, The G de (1985) Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet II: 407-409
6. Gore MM, Thakare JP, Ghosh SN, Wadia RS (1988) Are these autoimmune disorder induced by altered antigens? Arch Neurol 45: 601-602
7. Hara H, Morita M, Iwaki T, Hatae T, Itoyama Y, Kitamoto T, Akizuki S, Goto I, Watanabe T (1994) Detection of human T lymphotrophic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor V beta CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J Exp Med 180: 831-839
8. HiguchI I, Nerenberg M, Yoshimine K, Yoshida M, Fukunaga H, Tajima K, Osame M (1992) Failure to detect HTLV-I by in situ hybridization in the biopsied muscles of viral carriers with polymyositis. Muscle Nerve 15: 43-47
9. Higuchi I, Hashimoto K, Kashio N, Izumo S, Matsuoka H, Nakagawa M, Osame M (1995) In situ polymerase chain reaction detection of HTLV-I provirus and expression of the p53 tumor suppressor gene in infiltrating cells in skeletal muscle from a patient with adult T cell leukemia. Acta Neuropathol 90: 323-327
10. + lymphocytes. Acta Neuropathol 92: 358-361
11. Hoellsberg P, Hafler DA (1993) Pathogenesis of diseases induced by human lymphotropic virus type I infection. N Engl J Med 328: 1173-1182
12. Iannone R, Sherman MP, Rodgers-Johnson PEB, Beilke MA, Mora CA, Amin RM, Tinsley SR, Papsidero LD, Poiesz BJ, Gibbs CJ Jr (1992) HTLV-I DNA sequences in CNS tissue of a patient with tropical spastic paraparesis and HTLV-I-associated myelopathy. J Acquir Immune Defic Syndr 5: 810-816
13. Ijichi S, Eiraku N, Osame N, Izumo S, Kubota R, Maruyama I, Sonoda S (1988) Hypothetical pathogenesis of HAM/TSP: occurrence of proliferative response of lymphocytes in the central nervous system. In: Roman GC, Vernant JC, Osame M (eds) HTLV-I and the nervous system. Liss, New York, pp 337-342
14. Ijichi S, Izumo S, Eiraku N, Machigashira K, Kubota R, Nagai M, Ikegami N, Kashio N, Umehara F, Maruyama I, Osame M (1993) An autoaggressive process against bystander tissues in HTLV-I-infected individuals: a possible pathomechanism of HAM/TSP. Med Hypotheses 41: 542-547
15. + cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature 348: 245-248
16. Jacobson S, McFarlin DE, Robinson S, Voskuhl R, Martin R, Brewah A, Newell AJ, Koenig S (1992) HTLV-I-specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I-associated neurological disease. Ann Neurol 32: 651-657
17. Kashio N, Izumo S, Ijichi S, Hashimoto K, Umehara F, Higuchi I, Osame M (1994) Detection of HTLV-I provirus by in situ polymerase chain reaction in mononuclear cells infiltrating spinal cord lesions from HAM/TSP patients. Brain Pathol 4: 498
18. Koyanagi Y, Itoyama Y, Nakamura N, Takamatsu K, Kira J, Iwamasa T, Goto I, Yamamoto N (1993) In vivo infection of human T-cell leukemia virus type I in non-T cells. Virology 196: 25-33
19. + lymphocytes in the spinal cord from patients with HTLV-I-associated myelopathy. J Neuroimmunol 53: 23-29
20. Kuroda Y, Matsui M, Kikuchi M, Kurohara K, Endo C, Yikitake M, Matsuda Y, Tokunaga O, Komine-Sasaki A, Kawaguchi R (1994) In situ demonstration of the HTLV-I genome in the spinal cord of a patient with HTLV-I-associated myelopathy. Neurology 44: 2295-2299
21. Lehky TJ, Fox CH, Koenig S, Levin MC, Flerlage N, Izumo S, Sato E, Raine CS, Osame M, Jacobson S (1995) Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/ tropical spastic paraparesis patients by in situ hybridization. Ann Neurol 37: 167-175
22. + T lymphocytes. Ann Neurol 40: 84-90
23. Ohara Y, Iwasaki Y, Izumo S, Kobayashi I, Yoshioka A (1992) Search for human T-cell leukemia virus type I (HTLV-I) proviral sequences by polymerase chain reaction in the central nervous system tissue of HTLV-I-associated myelopathy. Arch Virol 124: 31-43
24. Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A (1986) HTLV-I associated myelopathy: A new clinical entity. Lancet I: 1031-1032
25. Osame M, Matsumoto M, Usuku K, Izumo S, Ijichi S, Amitani H, Tara M, Igata A (1987) Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemia like cells. Ann Neurol 21: 117-122
26. Osame M, Igata A, Matsumoto M (1988) HTLV-I-associated myelopathy (HAM) revisited. In: Roman GC, Vernant JC, Osame M (eds) HTLV-I and the nervous system. Liss, New York, pp 213-223
27. Richardson JH, Edward AJ, Cruickshank JK, Rudge P, Dalgleish AG (1990) In vivo cellular tropism of human T-cell leukemia virus type 1. J Virol 64: 5682-5687
28. Sonoda S, Yashiki S, Takahashi K, Arima N, Daitoku Y, Matsumoto M, Matsumoto T, Tara M, Shinmyozu K, Sato K, Inoko H, Ando A, Tsuji K (1987) Altered HLA antigens expressed on T and B lymphocytes of adult T-cell leukemia/lymphoma patients and their relatives. Int J Cancer 40: 629-634
29. Teo IA, Shaunak S (1995) Polymerase chain reaction in situ: an appraisal of an emerging technique. Histochem J 27: 647-659
30. Umehara F, Izumo S, Nakagawa M, Ronquillo AT, Takahashi K, Matsumuro K, Sato E, Osame M (1993) Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 52: 424-430
31. Umehara F, Izumo S, Ronquillo AT, Matsumuro K, Sato E, Osame M (1994) Cytokine expression in the spinal cord lesions in HTLV-I-associated myelopathy. J Neuropathol Exp Neurol 53: 72-77
32. Umehara F, Nakamura A, Izumo S, Kubota R, Ijichi S, Kashio N, Hashimoto K, Usuku K, Sato E, Osame M (1994) Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. J Neuropathol Exp Neurol 53: 617-624
33. Umehara F, Izumo S, Takeya M, Takahashi K, Sato E, Osame M (1996) Expression of adhesion molecules and monocyte chemoattractant protein-1 (MCP-1) in the spinal cord lesions in HTLV-I-associated myelopathy. Acta Neuropathol 91: 343-350