Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase

Cancer Research

Volumn 56, Issue 11, 1996, Pages 2535-2538

  Kinoshita, Takeshi ^a   Sato, Hiroshi ^a   Takino, Takahisa ^a   Itoh, Michiyasu ^b   Akizawa, Toshifumi ^b   Seiki, Motoharu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; COLLAGENASE; COLLAGENASE INHIBITOR; ENZYME ACTIVATOR; ENZYME PRECURSOR; GELATINASE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COLLAGENASES; ENZYME ACTIVATION; GELATINASES; GLYCOPROTEINS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; METALLOENDOPEPTIDASES; PHENYLALANINE; PROTEASE INHIBITORS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; RECOMBINANT FUSION PROTEINS; THIOPHENES; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 0029891956     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Liotta, L A , Steeg, P. S., and Stetler-Stevenson, W G. Cancer metastasis and angiogenesis an imbalance of positive and negative regulation Cell, 64: 327-336, 1991.
2. Stetler-Stevenson, W. G., Aznavoorian, S., and Liotta, L A Tumor cell interaction with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol., 9. 541-573, 1993.
3. Matrisian, L. M. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet., 6: 121-125, 1990.
4. Okada, Y., Morodomi, T., Enghild, J. J., Suzuki, K., Yasui, A. Nakanishi, I. Salvesen, G., and Nagase, H. Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur. J. Biochem , 194. 721-730, 1990.
5. Nagase, H., Ogata, Y., Suzuki, K , Enghild, J J., and Salvesen, G. Biochem. Soc. Trans., 19: 715-718, 1991.
6. Ward, R. V., Atkinson, S. J., Slocombe, P. M., Docherty, A J., Reynolds, J J., and Murphy, G. Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes. Biochim. Biophys Acta, 1079: 242-246, 1991.
7. Strongin, A. Y , Marmer, B. L., Grant, G. A., and Goldberg, G. I Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2. J. Biol. Chem., 268. 14033-14039, 1993.
8. Brown, P. D., Kleiner, D E , Unsworth, E. J., and Stetler-Stevenson, W. G. Cellular activation of the 72 kDa type IV procollagenase/TIMP-2 complex Kidney Int., 43 163-170, 1993
9. Strongin, A Y., Collier, I., Bannikov, G., Marmer, B. L., Grant, G A., and Goldberg, G. I. Mechanism of cell surface activation of 72-kDa type IV collagenase: isolation of the activated form of the membrane metalloprotease J. Biol. Chem , 270. 5331-5338, 1995.
10. Atkinson, S. J., Crabbe, T., Cowell, S , Ward, R V., Butler, M. J., Sato, H., Seiki, M , Reynolds, J. J., and Murphy, G. Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membrane J Biol. Chem., 270: 30479-30485, 1995
11. Monsky, W L., and Chen, W. T Proteases of cell adhesion proteins in cancer. Semin Cancer Biol , 4: 251-258, 1993
12. Sato, H., Takino, T , Okada, Y., Cao, J , Shinagawa, A., Yamamoto, E., and Seiki, M. A matrix metalloproteinase expressed on the surface of invasive tumor cells Nature (Lond.), 370: 61-65, 1994.
13. Okada, A., Bellocq, J. P., Rouyer, N., Chenard, M. P., Rio, M. C. Chambon, P., and Basset, P. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl. Acad Sci. USA, 92: 2730-2734, 1995
14. Nomura, H., Sato, H., Seiki, M., Mai, M , and Okada, Y Expression of membrane-type matrix metalloproteinase in human gastric carcinomas. Cancer Res., 55: 3263-3266, 1995.
15. Tokuraku, M., Sato, H , Murakami, S., Okada, Y , Watanabe, Y., and Seiki, M Activation of the precursor of gelatinase A/72-kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis. Int. J Cancer, 64. 355-359, 1995.
16. Brown, P D Matrix metalloproteinase inhibitors: a new class of anti-cancer agents. Curr. Drugs Opin. Invest., 2: 617-626, 1993.
17. Smith, D B., and Johnson, K S Single-step purification of polypeptide expressed in Eschericta coli as fusions with glutathione S-transferase Gene (Amst.), 67: 31-40, 1988.
18. Sato, H , and Seiki, M. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene, 8. 395-405, 1993
19. Van Wart, H. E., and Birkedal-Hansen, H. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc Natl. Acad. Sci USA, 87. 5578-5582, 1990
20. Cao, J., Sato, H., Takino, T., and Seiki, M The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for progelatinase A activation. J. Biol. Chem , 270: 801-805, 1995