Dependence of transition state structure on substrate: The intrinsic C-13 kinetic isotope effect is different for physiological and slow substrates of the ornithine decarboxylase reaction because of different hydrogen bonding structures

Journal of the American Chemical Society

Volumn 127, Issue 15, 2005, Pages 5414-5422

  Sicinska, Daria ^a   Truhlar, Donald G ^b   Paneth, Piotr ^a  

^a LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHEMICAL BONDS; ELECTRONIC STRUCTURE; HYDROGEN BONDS; ISOTOPES; MATHEMATICAL MODELS; QUANTUM THEORY; REACTION KINETICS;

DISSOCIATING BONDS; ISOTOPE EFFECTS; MOLECULAR MECHANICAL (MM) METHOD; TRANSITION STATE STRUCTURE;

ENZYMES;

HYDROGEN; ISOTOPE; ORNITHINE DECARBOXYLASE; POLYAMINE; PUTRESCINE;

ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; DISSOCIATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROGEN BOND; MOLECULAR MECHANICS; PHASE TRANSITION; QUANTUM MECHANICS; STRUCTURE ANALYSIS; WILD TYPE;

CARBON ISOTOPES; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; ORNITHINE; ORNITHINE DECARBOXYLASE; PUTRESCINE; QUANTUM THEORY; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 17644384320     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja042298p     Document Type: Article

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