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Volumn 20, Issue 5, 2004, Pages 261-271

Combined effect of epirubicin and lymphokine-activated killer cells on the resistant human breast cancer cells

Author keywords

Cytotoxicity; Epirubicin; LAK; MCF 7 cells; Reactive oxygen species

Indexed keywords

EPIRUBICIN; GLUTATHIONE PEROXIDASE; GLYCOPROTEIN P; HYDROXYL RADICAL; OXYGEN RADICAL; SUPEROXIDE; SUPEROXIDE DISMUTASE;

EID: 17644373821     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-004-3471-6     Document Type: Article
Times cited : (8)

References (53)
  • 1
    • 0016689082 scopus 로고
    • The use of acetylated ferricytochrome c for the detection of superoxide radicals produced in biological membranes
    • Azzi S, Montecucco C, Richter C. The use of acetylated ferricytochrome c for the detection of superoxide radicals produced in biological membranes. Biochem Biophys Res Commun. 1975;65:597-603.
    • (1975) Biochem Biophys Res Commun , vol.65 , pp. 597-603
    • Azzi, S.1    Montecucco, C.2    Richter, C.3
  • 2
    • 0020065649 scopus 로고
    • Nuclear-catalysed antibiotic free radical formation
    • Bachur NR, Gee MV, Friedman RD. Nuclear-catalysed antibiotic free radical formation. Cancer Res. 1982;42:1078-81.
    • (1982) Cancer Res , vol.42 , pp. 1078-1081
    • Bachur, N.R.1    Gee, M.V.2    Friedman, R.D.3
  • 3
    • 0023037085 scopus 로고
    • Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells
    • Batist G, Tulpule A, Sinha BK, Katki AG, Myers CE, Cowan KH. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J Biol Chem. 1986;261:15544-9.
    • (1986) J Biol Chem , vol.261 , pp. 15544-15549
    • Batist, G.1    Tulpule, A.2    Sinha, B.K.3    Katki, A.G.4    Myers, C.E.5    Cowan, K.H.6
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantisation of microgram quantities of protein utilising the principle of protein dye binding
    • Bradford MM. A rapid and sensitive method for the quantisation of microgram quantities of protein utilising the principle of protein dye binding. Anal Biochem. 1976;72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 0033086395 scopus 로고    scopus 로고
    • Cytotoxicities of low dose anticancer agents combining lymphokine activated killer cell against ovarian adenocarcinoma cell line SKOV3
    • Chen R, Pan L, Zhou S. Cytotoxicities of low dose anticancer agents combining lymphokine activated killer cell against ovarian adenocarcinoma cell line SKOV3. Zhonghua Fu Chan Ke Za Zhi. 1999;34:172-4.
    • (1999) Zhonghua Fu Chan Ke Za Zhi , vol.34 , pp. 172-174
    • Chen, R.1    Pan, L.2    Zhou, S.3
  • 6
    • 0033495123 scopus 로고    scopus 로고
    • Glutathione-dependent cytotoxicity of the chloroacetanilide herbicides alachlor, metolachor, and propachlor in rat and human hepatoma-derived cultured cells
    • Dierickx PJ. Glutathione-dependent cytotoxicity of the chloroacetanilide herbicides alachlor, metolachor, and propachlor in rat and human hepatoma-derived cultured cells. Cell Biol Toxicol. 1999;15:325-32.
    • (1999) Cell Biol Toxicol , vol.15 , pp. 325-332
    • Dierickx, P.J.1
  • 7
    • 0028015644 scopus 로고
    • Epirubicin in hepatocellular carcinoma: Pharmacokinetics and clinical activity
    • Dobbs NA, Twelwes CJ, Rizzi P, et al. Epirubicin in hepatocellular carcinoma: pharmacokinetics and clinical activity. Cancer Chem Pharm. 1994;34:405-10.
    • (1994) Cancer Chem Pharm , vol.34 , pp. 405-410
    • Dobbs, N.A.1    Twelwes, C.J.2    Rizzi, P.3
  • 8
    • 0000130569 scopus 로고
    • Multiple range and multiple F test
    • Duncan DB. Multiple range and multiple F test. Biometrics. 1955;11:1-14.
    • (1955) Biometrics , vol.11 , pp. 1-14
    • Duncan, D.B.1
  • 9
    • 3042934967 scopus 로고
    • Tissue sulfhydril groups
    • Ellman GL. Tissue sulfhydril groups. Arch Biochem Biophys. 1959;82:70-7.
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 10
    • 0029928413 scopus 로고    scopus 로고
    • Augmentation of epirubicin cytotoxicity by cycloheximide
    • Furusawa S, Nakana S, Wada M, et al. Augmentation of epirubicin cytotoxicity by cycloheximide. Res Commun Mol Path Pharm. 1996;91:245-52.
    • (1996) Res Commun Mol Path Pharm , vol.91 , pp. 245-252
    • Furusawa, S.1    Nakana, S.2    Wada, M.3
  • 11
    • 0024548599 scopus 로고
    • Expression of a multidrug resistance gene in human cancers
    • Goldstein LJ, Galski H, Fajo A, et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst. 1989;81:116-24.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 116-124
    • Goldstein, L.J.1    Galski, H.2    Fajo, A.3
  • 12
    • 0016325160 scopus 로고
    • Enzymatic conjugation of foreign chemical compounds by rabbit lung and liver
    • Gram TE, Litterst CL, Mimnaugh EG. Enzymatic conjugation of foreign chemical compounds by rabbit lung and liver. Drug Metab Dispos. 1974;2:254-8.
    • (1974) Drug Metab Dispos , vol.2 , pp. 254-258
    • Gram, T.E.1    Litterst, C.L.2    Mimnaugh, E.G.3
  • 13
    • 0019951384 scopus 로고
    • Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes
    • Grimm E. Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med. 1982;155:1823-41.
    • (1982) J Exp Med , vol.155 , pp. 1823-1841
    • Grimm, E.1
  • 14
    • 0031889918 scopus 로고    scopus 로고
    • Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro
    • Grunberg E, Eckert K, Maurer HR. Docetaxel treatment of HT-29 colon carcinoma cells reinforces the adhesion and immunocytotoxicity of peripheral blood lymphocytes in vitro. Int J Oncol. 1998;12:957-63.
    • (1998) Int J Oncol , vol.12 , pp. 957-963
    • Grunberg, E.1    Eckert, K.2    Maurer, H.R.3
  • 15
    • 0019741605 scopus 로고
    • Assay for differentiation of glutathione 5-transferases
    • Habig WH, Jakoby WB. Assay for differentiation of glutathione 5-transferases. Methods Enzymol. 1974;77:398-405.
    • (1974) Methods Enzymol , vol.77 , pp. 398-405
    • Habig, W.H.1    Jakoby, W.B.2
  • 16
    • 0025819592 scopus 로고
    • Induction of in vitro resistance to 4′-epidoxorubicin and cis-dichlorodiammineplatinum in hepatoma cells
    • Hall KS, Endresen L, Huitfeldt, HS, Rugstad HE. Induction of in vitro resistance to 4′-epidoxorubicin and cis-dichlorodiammineplatinum in hepatoma cells. Anticancer Res. 1991;11:817-24.
    • (1991) Anticancer Res , vol.11 , pp. 817-824
    • Hall, K.S.1    Endresen, L.2    Huitfeldt, H.S.3    Rugstad, H.E.4
  • 17
    • 0027531682 scopus 로고
    • A new approach for measurement of cytotoxicity using colorimetric assay
    • Hussain RF, Nouri AME, Oliver, RTD. A new approach for measurement of cytotoxicity using colorimetric assay. J Immunol Methods. 1993;160:89-95.
    • (1993) J Immunol Methods , vol.160 , pp. 89-95
    • Hussain, R.F.1    Nouri, A.M.E.2    Oliver, R.T.D.3
  • 18
    • 0032743612 scopus 로고    scopus 로고
    • Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity
    • Jansson Ö, Motlagh PB, Persson M, Henrikson R, Grankvist K. Increase in doxorubicin cytotoxicity by carvedilol inhibition of P-glycoprotein activity. Biochem Pharmacol. 1999;58:1801-6.
    • (1999) Biochem Pharmacol , vol.58 , pp. 1801-1806
    • Jansson, Ö.1    Motlagh, P.B.2    Persson, M.3    Henrikson, R.4    Grankvist, K.5
  • 20
    • 0022573017 scopus 로고
    • Overwiev of enzyme system involved in bioreduction of drugs and in redox cycling
    • Kappus H. Overwiev of enzyme system involved in bioreduction of drugs and in redox cycling. Biochem Pharmacol. 1986;35:419-25.
    • (1986) Biochem Pharmacol , vol.35 , pp. 419-425
    • Kappus, H.1
  • 21
    • 0031930390 scopus 로고    scopus 로고
    • Endogenous antioxidant enzymes and glutathione S-transferase in protection of mesothelioma cells against hydrogen peroxide and epirubicin toxicity
    • Kinnula K, Linnaynma K, Rayvyo KO, Kinnula VL. Endogenous antioxidant enzymes and glutathione S-transferase in protection of mesothelioma cells against hydrogen peroxide and epirubicin toxicity. Br J Cancer. 1998;77:1097-20.
    • (1998) Br J Cancer , vol.77 , pp. 1097-1120
    • Kinnula, K.1    Linnaynma, K.2    Rayvyo, K.O.3    Kinnula, V.L.4
  • 22
    • 0141993296 scopus 로고    scopus 로고
    • Lymphokine-activated killer cells can kill target cells not only early killing but also by late killing, and the late killing level against autotumor cell line
    • Komatsu F, Ishiguro K. Lymphokine-activated killer cells can kill target cells not only early killing but also by late killing, and the late killing level against autotumor cell line. Oncol Res. 2003;13:235-41.
    • (2003) Oncol Res , vol.13 , pp. 235-241
    • Komatsu, F.1    Ishiguro, K.2
  • 23
    • 0028363694 scopus 로고
    • Inversed expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells
    • Kotoh S, Naito S, Yokoniza A, et al. Inversed expression of DNA topoisomerase I gene and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res. 1994;54:3248-52.
    • (1994) Cancer Res , vol.54 , pp. 3248-3252
    • Kotoh, S.1    Naito, S.2    Yokoniza, A.3
  • 24
    • 0034253395 scopus 로고    scopus 로고
    • Cytokines secreted by lymhokine-activated killer cells induced endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells
    • Kwak JY, Han MK, Choy KS, et al. Cytokines secreted by lymhokine-activated killer cells induced endogenous nitric oxide synthesis and apoptosis in DLD-1 colon cancer cells. Cell Immunol. 2000;203:84-94.
    • (2000) Cell Immunol , vol.203 , pp. 84-94
    • Kwak, J.Y.1    Han, M.K.2    Choy, K.S.3
  • 25
    • 0017067418 scopus 로고
    • Glutathione peroxidase activity in selenium deficient rat liver
    • Lawrence RA, Burk RF. Glutathione peroxidase activity in selenium deficient rat liver. Biochem Biophys Res Commun. 1976;71:952-8.
    • (1976) Biochem Biophys Res Commun , vol.71 , pp. 952-958
    • Lawrence, R.A.1    Burk, R.F.2
  • 26
    • 0036204867 scopus 로고    scopus 로고
    • Partial circumvention of P-glycoprotein-mediated multidrug-resistance by doxorubicin-14-O-hemiadipe
    • Leontieva OV, Preobrazhenskaya MN, Bernacki RJ. Partial circumvention of P-glycoprotein-mediated multidrug-resistance by doxorubicin-14-O-hemiadipe. Invest New Drugs. 2002;20:35-48.
    • (2002) Invest New Drugs , vol.20 , pp. 35-48
    • Leontieva, O.V.1    Preobrazhenskaya, M.N.2    Bernacki, R.J.3
  • 27
    • 0002191974 scopus 로고
    • Catalase
    • HU Bergmeyer, editor. New York: Verlag Chemie Academic Press
    • Luck H. Catalase. In: HU Bergmeyer, editor. Methods of enzymatic analayses. New York: Verlag Chemie Academic Press, 1963:885-94.
    • (1963) Methods of Enzymatic Analayses , pp. 885-894
    • Luck, H.1
  • 28
    • 0033667302 scopus 로고    scopus 로고
    • Cisplatin induces Fas expression in oesophageal cancer cell lines and enhanced cytotoxicity in combination with LAK cells
    • Matsuzaki I, Suzuki H, Kitamura M, Minamiya Y, Kawai H, Ogawa J. Cisplatin induces Fas expression in oesophageal cancer cell lines and enhanced cytotoxicity in combination with LAK cells. Oncology. 2000;59:336-43.
    • (2000) Oncology , vol.59 , pp. 336-343
    • Matsuzaki, I.1    Suzuki, H.2    Kitamura, M.3    Minamiya, Y.4    Kawai, H.5    Ogawa, J.6
  • 29
    • 0014691242 scopus 로고
    • Preparation and assays of superoxide dismutase
    • McCord JM, Fridovich IJ. Preparation and assays of superoxide dismutase. Biol Chem. 1969;244:6049-55.
    • (1969) Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.J.2
  • 30
    • 0024493715 scopus 로고
    • Differential oxygen radical susceptibility of adriamycin-sensitive and resistant MCF-7 human breast tumor cells
    • Mimnaugh EG, Dusre L, Atwell J, Myers CE. Differential oxygen radical susceptibility of adriamycin-sensitive and resistant MCF-7 human breast tumor cells. Cancer Res. 1989;49:8-15.
    • (1989) Cancer Res , vol.49 , pp. 8-15
    • Mimnaugh, E.G.1    Dusre, L.2    Atwell, J.3    Myers, C.E.4
  • 31
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 32
    • 0032433804 scopus 로고    scopus 로고
    • cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro
    • Okamoto M, Kasetani H, Kaji R, et al. cis-Diamminedichloroplatinum and 5-fluorouracil are potent inducers of the cytokines and natural killer cell activity in vivo and in vitro. Cancer Immunol Immunother. 1998;4:233-41.
    • (1998) Cancer Immunol Immunother , vol.4 , pp. 233-241
    • Okamoto, M.1    Kasetani, H.2    Kaji, R.3
  • 33
    • 0141842775 scopus 로고    scopus 로고
    • Epirubicin cytotoxicity in non-small cell lung cancer (NSCLC) cells
    • Ozkan A, Fiskin K. Epirubicin cytotoxicity in non-small cell lung cancer (NSCLC) cells. Turkish J Hematol Oncol. 2003;13:125-33.
    • (2003) Turkish J Hematol Oncol , vol.13 , pp. 125-133
    • Ozkan, A.1    Fiskin, K.2
  • 36
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70:158-69.
    • (1967) J Lab Clin Med , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 37
    • 21844508121 scopus 로고
    • Partial circumvention of P-glycoprotein (Pgp)-associated resistance to doxorubicin (Dox) in MCF7/R human breast carcinoma and P388/R murine leukemia cell lines by doxorubicin-14-O-hemiadipate (H-Dox)
    • Pavarov LS, Leontieva OV, Preobrazhenskaya MN. partial circumvention of P-glycoprotein (Pgp)-associated resistance to doxorubicin (Dox) in MCF7/R human breast carcinoma and P388/R murine leukemia cell lines by doxorubicin-14-O- hemiadipate (H-Dox). Russian J Bioorg Chem 1995;21:797-803.
    • (1995) Russian J Bioorg Chem , vol.21 , pp. 797-803
    • Pavarov, L.S.1    Leontieva, O.V.2    Preobrazhenskaya, M.N.3
  • 38
    • 0022530989 scopus 로고
    • Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis
    • Phillips JH, Lanier LL. Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis. J Exp Med. 1986;164:814-19.
    • (1986) J Exp Med , vol.164 , pp. 814-819
    • Phillips, J.H.1    Lanier, L.L.2
  • 39
    • 0027368830 scopus 로고
    • Role of natural killer cells in cancer
    • Pross HF, Lotzova E. Role of natural killer cells in cancer. Nat Immun. 1993;12:279-92.
    • (1993) Nat Immun , vol.12 , pp. 279-292
    • Pross, H.F.1    Lotzova, E.2
  • 40
    • 0034738652 scopus 로고    scopus 로고
    • Discrimination between NK and LAK cytotoxicity activities of murine spleen cells by MTT assay: Differential inhibition by PGE2 and EDTA
    • Ribeiro-Dias F, Barbuto JAM, Tsujita M, Jancar S. Discrimination between NK and LAK cytotoxicity activities of murine spleen cells by MTT assay: differential inhibition by PGE2 and EDTA. J Immun Meth. 2000;241:121-9.
    • (2000) J Immun Meth , vol.241 , pp. 121-129
    • Ribeiro-Dias, F.1    Barbuto, J.A.M.2    Tsujita, M.3    Jancar, S.4
  • 41
    • 0037122737 scopus 로고    scopus 로고
    • Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs
    • Rihova B, Strohalm J, Kubackova K. Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs. J Control Release. 2002;17:97-114.
    • (2002) J Control Release , vol.17 , pp. 97-114
    • Rihova, B.1    Strohalm, J.2    Kubackova, K.3
  • 42
    • 0343526338 scopus 로고    scopus 로고
    • Reduction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypic reducers in human hepatocytes
    • Runge D, Köhler C, Kostrubsky EV, et al. Reduction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypic reducers in human hepatocytes. Biochem Bioph Res Commun. 2000;27 333-41.
    • (2000) Biochem Bioph Res Commun , vol.27 , pp. 333-341
    • Runge, D.1    Köhler, C.2    Kostrubsky, E.V.3
  • 43
    • 0029850782 scopus 로고    scopus 로고
    • P-Glycoproteinmediated multidrug resistance and lymphokine-activated killer cell susceptibility in ovarian carcinoma
    • Savas B, Cole PC, Tsuruo T, Pross HF. P-Glycoproteinmediated multidrug resistance and lymphokine-activated killer cell susceptibility in ovarian carcinoma. J Clin Immunol. 1996;16:348-57.
    • (1996) J Clin Immunol , vol.16 , pp. 348-357
    • Savas, B.1    Cole, P.C.2    Tsuruo, T.3    Pross, H.F.4
  • 44
    • 0032429984 scopus 로고    scopus 로고
    • Lymphokineactivated killer cell susceptibility and multidrug resistance in small cell lung carcinoma
    • Savas B, Kerr PE, Ustun H, Cole SPC, Pross HF. Lymphokineactivated killer cell susceptibility and multidrug resistance in small cell lung carcinoma. Anticancer Res. 1998;18:4355-62.
    • (1998) Anticancer Res , vol.18 , pp. 4355-4362
    • Savas, B.1    Kerr, P.E.2    Ustun, H.3    Cole, S.P.C.4    Pross, H.F.5
  • 45
    • 0030908214 scopus 로고    scopus 로고
    • Enhanced in vitro cytotoxicity of Idarubicin in rat prostate carcinoma cells
    • Siegsmund MJ, Steidler A, Kreukler C, Köhrmann KU, Alken P. Enhanced in vitro cytotoxicity of Idarubicin in rat prostate carcinoma cells. Eur Urol. 1997;31:365-70.
    • (1997) Eur Urol , vol.31 , pp. 365-370
    • Siegsmund, M.J.1    Steidler, A.2    Kreukler, C.3    Köhrmann, K.U.4    Alken, P.5
  • 46
    • 0023236652 scopus 로고
    • Differential formation of hydroxyl radical by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: Implications for the mechanism of action
    • Sinha BK, Katki AG, Batists G, Cowan KH, Myers CH. Differential formation of hydroxyl radical by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action. Biochem. 1987;26:3776-81.
    • (1987) Biochem , vol.26 , pp. 3776-3781
    • Sinha, B.K.1    Katki, A.G.2    Batists, G.3    Cowan, K.H.4    Myers, C.H.5
  • 48
    • 0038639294 scopus 로고    scopus 로고
    • Preventive treatments for recurrence after curative resection hepatocellular carcinoma - A literature review of randomised control trials
    • Sun HC, Tang ZY. Preventive treatments for recurrence after curative resection hepatocellular carcinoma - a literature review of randomised control trials. World J Gastroenterol. 2003;9:635-40.
    • (2003) World J Gastroenterol , vol.9 , pp. 635-640
    • Sun, H.C.1    Tang, Z.Y.2
  • 49
    • 0001813369 scopus 로고
    • Biological roles of nitric oxide
    • Synder HS, Bredt DS. Biological roles of nitric oxide. Sci Am. 1992;5:28-34.
    • (1992) Sci Am , vol.5 , pp. 28-34
    • Synder, H.S.1    Bredt, D.S.2
  • 50
    • 0024792513 scopus 로고
    • Biology of natural killer cells
    • Trinchieri G. Biology of natural killer cells. Adv Immunol. 1989;47:187-92.
    • (1989) Adv Immunol , vol.47 , pp. 187-192
    • Trinchieri, G.1
  • 51
    • 73649173283 scopus 로고
    • Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver
    • Williams CH, Kamin H. Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver. J Biol Chem. 1962;237:587-95.
    • (1962) J Biol Chem , vol.237 , pp. 587-595
    • Williams, C.H.1    Kamin, H.2
  • 52
    • 0038714286 scopus 로고    scopus 로고
    • A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
    • Wolfram ES, Ryan P, Salvatore C, et al. A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects. Nat Med. 2003;9:750-5.
    • (2003) Nat Med , vol.9 , pp. 750-755
    • Wolfram, E.S.1    Ryan, P.2    Salvatore, C.3
  • 53
    • 0033800401 scopus 로고    scopus 로고
    • Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs
    • Yamamota T, Yoneda K, Ueta E, Doi S, Osaki T. Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs. Eur J Cancer. 2000;36:2007-17.
    • (2000) Eur J Cancer , vol.36 , pp. 2007-2017
    • Yamamota, T.1    Yoneda, K.2    Ueta, E.3    Doi, S.4    Osaki, T.5


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