Augmentation of epirubicin cytotoxicity by cycloheximide

Research Communications in Molecular Pathology and Pharmacology

Volumn 91, Issue 2, 1996, Pages 245-248

  Furusawa, Shinobu ^a   Nakano, Shinya ^a   Wada, Mizuki ^a   Chiba, Hiroaki ^a   Takayanagi, Motoaki ^a   Takayanagi, Yoshio ^a   Sasaki, Ken Ichi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOHEXIMIDE; EPIRUBICIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG CYTOTOXICITY; DRUG POTENTIATION; LEUKEMIA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL DIVISION; CYCLOHEXIMIDE; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; EPIRUBICIN; LEUKEMIA P388; MICE; PROTEIN SYNTHESIS INHIBITORS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 0029928413     PISSN: 00345164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Ganzina, F. (1983). 4'-Epi-doxorubicin, a new analogue of doxorubicin: A preliminary overview of preclinical and clinical data. Cancer Treat. Rev. 10, 1-22.
2. Tsukagoshi S. (1990). Epirubicin (4'-Epi-adiramycin). Jpn. J. Cancer Chemother. 17, 151-159.
3. Heo D.S., Park J.-G., Hata K., Day R., Herberman R.B. and Whiteside T.L. (1990). Evaluation of tetetrazolium-based semiautomatic colorimetric assay for measurement of human antitumor cytotoxicity. Cancer Res. 50, 3681-3690.
4. Bachur N.R., Moor A.L., Bernstein J.G. and Liu A. (1970). Tissue distribution and disposition of daunomycin (NSC-82151) in mice: Fluorometric and isotopic methods. Cancer Chemother. Rep. 54, 89-98 .
5. Furusawa S., Nakano S., Kosaka K., Takayanagi M., Takayanagi Y. and Sasaki K. (1995). Inhibition of doxorubicin-induced cell death in vitro and in vivo by cycloheximide. Biol. Pharm. Bull. 18, 1367-1372.
6. Thakkar N. and Potten C.S. (1992). Abrogation of adriamycin toxicity in vivo by cycloheximide. Biochem. Pharmacol. 43, 1683-1691.
7. Noguchi H., Reddy G.P.V. and Pardee A.B. (1983). Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei. Cell. 32, 443-451.
8. Rossow P.W., Riddle V.G. and Pardee A.B. (1979). Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. Proc. Natl. Acad. Sci. USA. 76, 4446-4450.
9. Schot B. and Robert J. (1989). Comparative cytotoxicity, DNA synthesis inhibition and drug incorporation of eight anthracyclines a model of doxorubicin-sensitive and -resistant rat glioblastoma cells. Biochem. Pharmacol. 38, 167-172.