Innate antimicrobial activity of nasal secretions

Infection and Immunity

Volumn 67, Issue 7, 1999, Pages 3267-3275

  Cole, Alexander M ^a   Dewan, Puneet ^a   Ganz, Tomas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ANTIBODY; BETA MICROSEMINOPROTEIN; DEFENSIN; DODECYL SULFATE SODIUM; IMMUNOGLOBULIN G; LACTOFERRIN; LYSOZYME; PHOSPHOLIPASE A2; PROTEIN; STATHERIN; UREA;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CARRIER; COLONY FORMING UNIT; GENE; HOST RESISTANCE; HUMAN; IMMUNOBLOTTING; NOSE SECRETION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

EID: 0032968506     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.7.3267-3275.1999     Document Type: Article

References (44)

1. Aho, H. J., R. Grenman, J. Sipila, H. Peuravuori, J. Hartikainen, and T. J. Nevalainen. 1997. Group II phospholipase A2 in nasal fluid, mucosa and paranasal sinuses. Acta Otolaryngol. 117:860-863.
2. Azen, E. A. 1993. Genetics of salivary protein polymorphisms. Crit. Rev. Oral Biol. Med. 4:479-485.
3. Biesbrock, A. R., M. S. Reddy, and M. J. Levine. 1991. Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect. Immun. 59:3492-3497.
4. Brogden, K. A., M. Ackermann, and K. M. Huttner. 1998. Detection of anionic antimicrobial peptides in ovine bronchoalveolar lavage fluid and respiratory epithelium. Infect. Immun. 66:5948-5954.
5. Ellison, R. T., III, and T. J. Giehl. 1991. Killing of gram-negative bacteria by lactoferrin and lysozyme. J. Clin. Invest. 88:1080-1091.
6. Ferguson, J. L., T. V. McCaffrey, E. B. Kern, and W. J. Martin. 1988. The effects of sinus bacteria on human ciliated nasal epithelium in vitro. Otolaryngol. Head Neck Surg. 98:299-304.
7. Fernlund, P., L. B. Granberg, and I. Larsson. 1996. Cloning of β-microseminoprotein of the rat: a rapidly evolving mucosal surface protein. Arch. Biochem. Biophys. 334:73-82.
8. Fleming, A. 1922. On a remarkable bacteriolytic element found in tissues and secretions. Proc. R. Soc. Lond. (Biol.) 93:305-317.
9. Ganz, T., M. E. Selsted, D. Szklarek, S. S. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer. 1985. Defensins: natural peptide antibiotics of human neutrophils. J. Clin. Invest. 76:1427-1435.
10. Ganz, T., and J. Weiss. 1997. Antimicrobial peptides of phagocytes and epithelia. Semin. Hematol. 34:343-354.
11. Hancock, R. E., L. M. Mutharia, L. Chan, R. P. Darveau, D. P. Speert, and G. B. Pier. 1983. Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect. Immun. 42:170-177.
12. Harder, J., J. Bartels, E. Christophers, and J.-M. Schroeder. 1997. A peptide antibiotic from human skin. Nature 387:861-862.
13. Imundo, L., J. Barasch, A. Prince, and Q. Al-Awqati. 1995. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc. Natl. Acad. Sci. USA 92:3019-3023.
14. Jensen, J. L., T. Xu, M. S. Lamkin, P. Brodin, H. Aars, T. Berg, and F. G. Oppenheim. 1994. Physiological regulation of the secretion of histatins and statherins in human parotid saliva. J. Dent. Res. 73:1811-1817.
15. Kaliner, M. A. 1991. Human nasal respiratory secretions and host defense. Am. Rev. Respir. Dis. 144:S52-S56.
16. Kaliner, M. A. 1992. Human nasal host defense and sinusitis. J. Allergy Clin. Immunol. 90:424-430.
17. Kaulbach, H. C., M. V. White, Y. Igarashi, B. K. Hahn, and M. A. Kaliner. 1993. Estimation of nasal epithelial lining fluid using urea as a marker. J. Allergy Clin. Immunol. 92:457-465.
18. Kluytmans, J., A. van Belkum, and H. Verbrugh. 1997. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev. 10:505-520.
19. Knowles, M. R., J. M. Robinson, R. E. Wood, C. A. Pue, W. M. Mentz, G. C. Wager, J. T. Gatzy, and R. C. Boucher. 1997. Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. J. Clin. Invest. 100:2588-2595.
20. Krivan, H. C., D. D. Roberts, and V. Ginsburg. 1988. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids. Proc. Natl. Acad. Sci. USA 85: 6157-6161.
21. Lee, I. H., Y. Cho, and R. I. Lehrer. 1997. Effects of pH and salinity on the antimicrobial properties of clavanins. Infect. Immun. 65:2898-2903.
22. Li, J. D., A. F. Dohrman, M. Gallup, S. Miyata, J. R. Gum, Y. S. Kim, J. A. Nadel, A. Prince, and C. B. Basbaum. 1997. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc. Natl. Acad. Sci. USA 94:967-972.
23. Lindahl, M., B. Stahlbom, and C. Tagesson. 1995. Two-dimensional gel electrophoresis of nasal and bronchoalveolar lavage fluids after occupational exposure. Electrophoresis 16:1199-1204.
24. Liu, L., L. Wang, H. P. Jia, C. Zhao, H. H. Q. Heng, B. C. Schutte, P. B. McCray, and T. Ganz. 1998. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 222:237-244.
25. Lorin, M. I., P. F. Gaerlan, and I. D. Mandel. 1972. Quantitative composition of nasal secretions in normal subjects. J. Lab. Clin. Med. 80:275-281.
26. Matsui, H., B. R. Grubb, R. Tarran, S. H. Randell, J. T. Gatzy, C. W. Davis, and R. C. Boucher. 1998. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95:1005-1015.
27. McCray, P. B. J., and L. Bentley. 1997. Human airway epithelia express a β-defensin. Am. J. Respir. Cell. Mol. Biol. 16:343-349.
28. McNeely, T. B., and J. D. Coonrod. 1993. Comparison of the opsonic activity of human surfactant protein A for Staphylococcus aureus and Streptococcus pneumoniae with rabbit and human macrophages. J. Infect. Dis. 167:91-97.
29. Meredith, S. D., G. D. Raphael, J. N. Baraniuk, S. M. Banks, and M. A. Kaliner. 1989. The pathophysiology of rhinitis. III. The control of IgG secretion. J. Allergy Clin. Immunol. 84:920-930.
30. Osserman, E. F., and D. P. Lawlor. 1966. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J. Exp. Med. 124:921-952.
31. Qu, X. D., K. C. Lloyd, J. H. Walsh, and R. I. Lehrer. 1996. Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells. Infect. Immun. 64:5161-5165.
32. Raphael, G. D., E. V. Jeney, J. N. Baraniuk, I. Kim, S. D. Meredith, and M. A. Kaliner. 1989. Pathophysiology of rhinitis. Lactoferrin and lysozyme in nasal secretions. J. Clin. Invest. 84:1528-1535.
33. Schagger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368-379.
34. Shuter, J., V. B. Hatcher, and F. D. Lowy. 1996. Staphylococcus aureus binding to human nasal mucin. Infect. Immun. 64:310-318.
35. Singh, P. K., H. P. Jia, K. Wiles, J. Hesselberth, L. Liu, B. D. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, B. F. Tack, and P. B. J. McCray. 1998. Production of β-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95:14961-14966.
36. Smith, A. 1997. Pathogenesis of bacterial bronchitis in cystic fibrosis. Pediatr. Infect. Dis. J. 16:91-95.
37. Smith, J. J., S. M. Travis, E. P. Greenberg, and M. J. Welsh. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:229-236.
38. Stadel, J. M., K. Hoyle, R. M. Naclerio, A. Roshak, and F. H. Chilton. 1994. Characterization of phospholipase A2 from human nasal lavage. Am. J. Respir. Cell. Mol. Biol. 11:108-113.
39. Steinberg, D. A., and R. I. Lehrer. 1997. Designer assays for antimicrobial peptides. Disputing the "one-size-fits-all" theory. Methods Mol. Biol. 78: 169-186.
40. Valore, E. V., C. H. Park, A. J. Quayle, K. R. Wiles, P. B. McCray, and T. Ganz. 1998. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1633-1642.
41. Weiber, H., C. Lindstrom, H. Lilja, A. Bjartell, and P. Fernlund. 1997. Immunohistochemical and in situ hybridization studies of β-microseminoprotein in the human gastric mucosa. Histochem. J. 29:839-845.
42. Widdicombe, J. H., and J. G. Widdicombe. 1995. Regulation of human airway surface liquid. Respir. Physiol. 99:3-12.
43. Zar, H., L. Saiman, L. Quittell, and A. Prince. 1995. Binding of Pseudomonas aeruginosa to respiratory epithelial cells from patients with various mutations in the cystic fibrosis transmembrane regulator. J. Pediatr. 126:230-233.
44. Zhao, C. Q., I. Wang, and R. I. Lehrer. 1996. Widespread expression of β-defensin HBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:319-322.