Enantioselective analysis of methadone in sweat as monitored by liquid chromatography/ion spray-mass spectrometry

Therapeutic Drug Monitoring

Volumn 20, Issue 1, 1998, Pages 35-40

  Kintz, Pascal ^a   Tracqui, Antoine ^a   Marzullo, Catherine ^b   Darreye, Angelina ^c   Tremeau, Fabien ^c   Greth, Philippe ^c   Ludes, Bertrand ^a  

^a INSTITUT DE MÉDECINE LÉGALE   (France)

^b Hôpitaux Universitaires de Strasbourg   (France)

^c Centre de Soins Pour Toxicomanes   (France)

Author keywords

Chiral separation; Liquid chromatography mass spectrometry; Methadone; Sweat

Indexed keywords

METHADONE;

ARTICLE; CHIRAL CHROMATOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MONITORING; FEMALE; HEROIN DEPENDENCE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PATIENT COMPLIANCE; PRIORITY JOURNAL; SWEAT;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; METHADONE; NARCOTICS; STEREOISOMERISM; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS; SWEAT;

EID: 0031951641     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199802000-00007     Document Type: Article

References (27)

1. Burns M, Baselt RC. Monitoring drug use with a sweat patch: An experiment with cocaine. J Anal Toxicol 1995;19:41-8.
2. Cone EJ, Hillsgrove MJ, Jenkins AJ, Keenan RM, Darwin WD. Sweat testing for heroin, cocaine, and metabolites. J Anal Toxicol 1994;18:298-305.
3. Kintz P, Tracqui A, Jamey C, Mangin P. Detection of codeine and phenobarbital in sweat collected with a sweat patch. J Anal Toxicol 1996;20:197-201.
4. Kintz P, Tracqui A, Mangin P. Sweat testing for benzodiazepines. J Forensic Sci 1996;41:851-4.
5. Fay J, Fogerson R, Schoendorfer D, Niedbala RS, Spiehler V. Detection of methamphetamine in sweat by EIA and GC/MS. J Anal Toxicol 1996;20:398-403.
6. Skopp G, Pötsch L, Eser HP, Möller MR. Preliminary practical findings on drug monitoring by a transcutaneous collection device. J Forensic Sci 1996;41:933-7.
7. Kintz P. Controlled excretion of MBDB and BDB in urine, saliva and sweat following single oral administration. J Anal Toxicol 1997;21:570-5.
8. Kintz P, Tracqui A, Mangin P, Edel Y. Sweat testing in opiod users with a sweat patch. J Anal Toxicol 1996;20:393-7.
9. Kintz P, Brenneisen R, Bundeli P, Mangin P. Sweat testing for heroin and metabolites in a heroin maintenance program. Clin Chem 1997;43:736-9.
10. Meresaar U, Nilsson MI, Holmstrand J, Anggard E. Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method. Eur J Clin Pharmacol 1981;20: 473-8.
11. Säwe J, Hangen J, Ginman C, et al. Patient controlled dose regiment of methadone for chronic cancer pain. Br Med J 1981;7: 771-3.
12. Judson BA, Horns WH, Goldstein A. Side effects of levomethadone and racemic methadone in a maintenance program. Clin Pharmacol Ther 1976;20:445-9.
13. Beck O, Boreus LO, Lafolie P, Jacodsson G. Chiral analysis of methadone in plasma by high-performance liquid chromatography. J Chromatogr Biomed Appl 1991;570:198-202.
14. Kristensen K, Angelo HR. Stereospecific gas chromatographic method for determination of methadone in serum. Chirality 1992; 4:263-7.
15. Kristensen K, Angelo HR, Blemmer T. Enantioselective high-performance liquid chromatographic method for the determination of methadone in serum using an AGP and CN column as chiral and analytical column, respectively. J Chromatogr 1994;666:283-7.
16. Rudaz S, Staub C, Veuthey JL. Application of stereoselective determination of methadone in biological matrices by HPLC following solid-phase extraction. In: Proceeding of the 34th International Congress of the International Association of Forensic Toxicologists, August 11-15, 1996. Interlaken, Switzerland.
17. Kintz P, Moeller MR, Berthault F, Tracqui A, Eser HP, Mangin P. Separation of methadone enantiomers in human urine and hair. In: Proceedings of the 48th Annual Meeting of the American Academy of Forensic Sciences, February 19-24, 1996. Nashville, TN, U.S.A.
18. Kintz P, Eser HP, Tracqui A, Moeller M, Cirimele V, Mangin P. Enantioselective separation of methadone and its main metabolite in human hair by liquid chromatography/ion spray-mass spectrometry. J Forensic Sci 1997;42:290-4.
19. Kidwell DA, Blank DL. Environmental exposure - the stumbling block of hair testing. In: Kintz P, ed. Drug testing in hair. Boca Raton: CRC Press, 1996;17-68.
20. Henderson GL, Wilson BK. Excretion of methadone and metabolites in human sweat. Res Com Chem Pathol Pharmacol 1973;5: 1-8.
21. Balabanova S, Schneider E, Bühler G, Krause H. Das Vorhandensein von Methadon in apokriner Schwei beim Menschen. Z Rechtsmed 1990;103:323-7.
22. Schneider E, Balabanova S. Nachweis von Drogen in körpernahen Wäschestücken. Arch Kriminol 1991;188:97-105.
23. Kintz P. Drug testing in addicts: a comparison between urine, sweat and hair. Ther Drug Monit 1996;18:450-5.
24. Fogerson R, Suttliff J, Walker C. Testing for cocaine and opiates with the PharmChek™ sweat patch. Proceedings of the Annual Meeting of the Society of Forensic Toxicologists, October 9-14, 1995. Baltimore, MD, U.S.A.
25. Baumgartner WA, Hill VA, Blahd WH. Hair analysis for drugs of abuse. J Forensic Sci 1989;34:1433-53.
26. Henderson GL, Haskey MR, Zhou C, Jones RT, Jacob P III. Incorporation of isotopically labeled cocaine and metabolites into human hair, I: Dose response relationships. J Anal Toxicol 1996; 20:1-12.
27. Nakahara Y, Ochiai T, Kikura R. Hair analysis for drugs of abuse. Arch Toxicol 1992;66:446-9.