Induction of apoptosis by adenovirus E4orf4 protein

Apoptosis

Volumn 5, Issue 3, 2000, Pages 211-215

  Kleinberger, T ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Adenovirus; Apoptosis; Cancer; Caspases; E4orf4; Gene therapy; Protein phosphatase 2A (PP2A)

Indexed keywords

CASPASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN E4ORF4; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS; APOPTOSIS; CANCER THERAPY; ENZYME ACTIVITY; ENZYME SUBUNIT; LIFE CYCLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE; VIRUS CELL TRANSFORMATION;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; GENE THERAPY; HUMANS; NEOPLASMS; PHOSPHOPROTEIN PHOSPHATASE; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; VIRAL PROTEINS;

ADENOVIRIDAE;

EID: 0033863639     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009644210581     Document Type: Review

References (37)

1. cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A
2. Induction of transcription factor AP- 1 by adenovirus E 1A protein and cAMP
3. Adenovirus E4orf4 protein reduces phosphorylation of c-fos and E1A proteins while simultaneously reducing the level of AP-1
4. Adenovirus E4 open reading 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter
5. Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen -activated protein kinase regulates expression of early region 4
6. Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein
7. Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins
8. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff
9. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription
10. Protein serine/threonine phosphatases: Structure, regulation, and functions in cell growth
11. Serine/threonine protein phosphatases
12. Comparison of heterotrimeric protein phosphatase 2A containing different B subunits
13. Identification of a new family of protein phosphatase 2A regulatory subunits
14. High complexity in the expression of the B' subunit of protein phosphatase 2A0
15. Regulation by tumor antigens defines a role for PP2A in signal transduction
16. Adenovirus E4orf4 protein interacts with both Bα and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα
17. Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
18. E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmk
19. The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent ceil death by apoptosis
20. Proteases to die for
21. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
22. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A
23. Kinase cascades regulating entry into apoptosis
24. Cellular survival: A play in three Akrs
25. BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol
26. Bci-2 phosphorylation required for anti-apoptotic function
27. Protein phosphorylation in apoptosis
28. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
29. Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis
30. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoprosis
31. Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis
32. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A
33. The mitochondrial FOF1-ATPase proton pump is required for function of the proapoptotic protein Bax in yeast and mammalian cells
34. Bax inhibitor-l, a mammalian apoptosis suppressor identified by functional screening in yeast
35. Oncogene-dependent apoptosis is mediated by caspase-9
36. The adenovirus E1B 19-Kilodalton protein overcomes the cytotoxicity of E1A proteins
37. Viruses andapoptosis