High affinity central benzodiazepine receptor ligands: Synthesis and structure-activity relationship studies of a new series of pyrazolo[4,3- c]quinolin-3-ones

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 4, 1998, Pages 389-399

  Savini, L ^a   Massarelli, P ^a   Nencini, C ^a   Pellerano, C ^a   Biggio, G ^b   Maciocco, A ^b   Tuligi, G ^b   Carrieri, A ^c   Cinone, N ^c   Carotti, A ^c  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

35S TBPS binding; Central benzodiazepine receptor ligands; Pharmacophore refinement; Pyrazolo 4,3 c quino lin 3 ones; QSAR

Indexed keywords

2 (4 CHLOROPHENYL) 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; 2 PHENYL 5H PYRAZOLO[4,3 C]QUINOLIN 3 ONE; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; FLUNITRAZEPAM; PYRAZOLO[4,3 C]QUINOLIN 3 ONE DERIVATIVE; PYRAZOLONE DERIVATIVE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN MEMBRANE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INFRARED RADIATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT;

ANIMALS; ANTI-ANXIETY AGENTS; CEREBRAL CORTEX; CULTURE TECHNIQUES; FLUNITRAZEPAM; GABA AGONISTS; GABA ANTAGONISTS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PYRAZOLES; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032054002     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10039-6     Document Type: Article

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