No increase of synthesis of (R)salsolinol in Parkinson's disease

Movement Disorders

Volumn 14, Issue 3, 1999, Pages 514-515

  Müller, Thomas ^a   Przuntek, Horst ^a   Kuhn, Wilfried ^a   Baum, Siedy Sällström ^b   Rommelspacher, Hans ^b  

^a ST JOSEF HOSPITAL   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; SALSOLINOL;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; ENANTIOMER; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; STEREOSPECIFICITY; SYNTHESIS;

ADULT; AGED; BRAIN; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; SALSOLINE ALKALOIDS;

EID: 17344387264     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8257(199905)14:3<514::AID-MDS1023>3.0.CO;2-2     Document Type: Article

References (6)

1. Maruyama W, Narabayashi H, Dostert P, Naoi M. Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline. N-methyl (R)salsolinol, in the human intraventricular fluid. J Neural Transm 1996;103:1069-1076.
2. Maruyama W, Abe T, Tohgi H, Dostert P, Naoi M. A dopaminergic neurotoxin, N-methyl (R)salsolinol, increases in parkinsonian cerebrospinal fluid. Ann Neurol 1996;40:119-122.
3. Gerlach M, Koutsilieri E, Riederer P. N-methlyl (R)salsolinol and its relevance to Parkinson's disease. Lancet 1998;351:850-851.
4. Müller T, Sällsträm Baum S, Häussermann P, et al. Plasma levels of R-and S-salsolinol are not increased in 'de-novo' parkinsonian patients. J Neural Transm 1998;105:239-246.
5. Naoi M, Maruyama W, Dostert P, Kohda K, Kaiya T. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl (R)salsolinol. Neurosci Lett 1996;212:183-186.
6. Naoi M, Maruyama W, Makao N, et al. (R)Salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes. Ann Neurol 1998;43:212-216.