Gradient of RGD-dependent entry of adenoviral vector in nasal and intrapulmonary epithelia: Implications for gene therapy of cystic fibrosis

Gene Therapy

Volumn 3, Issue 9, 1996, Pages 811-818

  Goldman, M ^a   Su, Q ^b   Wilson, J M ^a,b,c  

^a Department of Medicine ^*  (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WISTAR INSTITUTE   (United States)

Author keywords

(v) integrins; Adenoviral vectors; Cystic fibrosis; Gene therapy

Indexed keywords

INTEGRIN;

ADENOVIRUS; AMINO ACID SEQUENCE; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; EXPRESSION VECTOR; GENE THERAPY; GENE TRANSFER; INTERNALIZATION; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIGENS, CD; CYSTIC FIBROSIS; EPITHELIUM; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INTEGRIN ALPHAV; INTEGRIN BETA CHAINS; INTEGRINS; LUNG; MICE; MICE, INBRED C57BL; NASAL MUCOSA; NOSE; OLIGOPEPTIDES; TRACHEA;

ADENOVIRIDAE; ANIMALIA;

EID: 0029794845     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Boat T, Welsh M, Beaudet A. Cystic fibrosis. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds). Metabolic Basis of Inherited Diseases. 1989, pp 2649-2680.
2. Wilson J. Gene therapy for cystic fibrosis: challenges and future directions. J Clin Invest 1995; 96: 2547-2554.
3. Crystal RG et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat Genet 1994; 8: 42-51.
4. Rosenfeld MA et al. Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 1991; 252: 431-434.
5. Rosenfeld MA et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 1992; 68: 143-155.
6. Zabner J et al. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat Genet 1994; 6: 75-83.
7. Yang Y et al. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nat Genet 1994; 7: 362-369.
8. Brody SL et al. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum Gene Ther 1994; 5: 821-836.
9. Yei S et al. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Therapy 1994; 1: 192-200.
10. Bout A et al. In vivo adenovirus-mediated transfer of human CFTR cDNA to Rhesus monkey airway epithelium: efficacy, toxicity and safety. Gene Therapy 1994; 1: 385-394.
11. Zsengeller Z et al. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum Gene Ther 1995; 6: 457-467.
12. Grubb B et al. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 1994; 371: 802-806.
13. Knowles MR et al. A double-blind vehicle-controlled study of adenoviral vector mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. New Engl J Med 1995; 333: 823-831.
14. Zabner J et al. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 1993; 75: 207-216.
15. Hay J et al. Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector. Hum Gene Ther 1995; 6: 1487-1496.
16. Wickham TJ et al. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 1993; 73: 309-319.
17. Wickham T et al. Integrin αvβ5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol 1994; 127: 257-264.
18. Mathias P et al. Multiple adenovirus serotypes use αv integrins for infection. J Virol 1994; 68: 6811-6814.
19. White J. Integrins as virus receptors. Curr Biol 1993; 3: 596-599.
20. Shuang H, Endo R, Nemerow G. Upregulation of integrins αvβ3 and αvβ5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J Virol 1995; 69: 2257-2263.
21. Bai M, Harfe B, Freimuth P. Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. J Virol 1993; 67: 5198-5205.
22. Goldman MJ, Wilson JM. Expression of αvβ5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J Virol 1995; 69: 5951-5958.
23. Campisi L, Freimuth P. Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2. J Virol 1994; 68: 5925-5932.
24. Damjanovich L et al. Distribution of integrin cell adhesion receptors in normal and malignant lung tissue. Am J Respir Cell Mol Biol 1992; 6: 197-206.
25. Pasqualini R et al. A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies. J Cell Science 1993; 105: 101-111.
26. Mette S et al. Distribution of integrin cell adhesion receptors on normal bronchial epithelial cells and lung cancer cells in vitro and in vivo. Am J Respir Cell Mol Biol 1993; 8: 562-572.
27. Greber U et al. Stepwise dismantling of adenovirus 2 during entry into cells. Cell 1993; 75: 477-486.
28. Philipson L, Lonberg-Holm K, Pettersson U. Virus-receptor interaction in an adenovirus system. J Virol 1968; 2: 1064-1075.
29. Engelhardt J et al. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat Genet 1993; 4: 27-34.