Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster

Journal of Heredity

Volumn 87, Issue 3, 1996, Pages 175-190

  Wright, T R F ^a,b,c,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b YALE UNIVERSITY   (United States)

^c Wesleyan University ^*

^d WESLEYAN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; CATECHOLAMINE; MELANIN;

CATECHOLAMINE METABOLISM; CONFERENCE PAPER; CUTICLE; DROSOPHILA MELANOGASTER; GENE CLUSTER; GENE LOCUS; GENE MUTATION; LARVAL DEVELOPMENT; MELANOGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PSEUDOTUMOR; SKIN PIGMENTATION; ANIMAL; ENZYMOLOGY; GENE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MULTIGENE FAMILY; MUTATION; PIGMENTATION; REVIEW;

DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER;

ANIMALS; CATECHOLAMINES; DOPA DECARBOXYLASE; DROSOPHILA MELANOGASTER; GENES, INSECT; MULTIGENE FAMILY; MUTATION; PHENOTYPE; PIGMENTATION;

EID: 0030139169     PISSN: 00221503     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jhered.a022983     Document Type: Conference Paper

References (99)

1. Beall CJ and Hirsh J, 1984. High levels of intron-containing RNAs are associated with expression of the Drosophila DOPA decarboxylase gene. Mol Cell Biol 4: 1669-1674
2. Beall CJ and Hirsh J, 1986 Drosophila melanogaster Ddc gene transcripts are not expressed at high levels during early embryogenesis. Dev Biol 114:258-259.
3. Beall CJ and Hirsh J, 1987. Regulation of neuronal and glial expression of the Drosophila dopa decarboxylase gene. Genes Dev 1:510-520.
4. DE1, a mutant differentially affecting both stage and tissue specific expression of dopa decarboxylase in Drosophila. Genetics 115:477-491
5. Black BC, 1988. Studies of the genetics and biochemistry of catecholamine metabolism using Drosophila behavioral mutants. In: Progress in catecholamine research, part A: basic aspects and peripheral mechanisms (Dahlstrom A, Belmaker RH, and Sandler M, eds). New York: Alan R Liss; 297-302
6. Black BC, Pentz ES, and Wright TRF, 1987. The alpha methyl dopa hypersensitive gene, l(2)amd, and two adjacent genes in Drosophila melanogaster Physical location and direct effects of amd on catecholamine metabolism Mol Gen Genet 209:306-312
7. Bray SJ, Burke B, Brown NH, and Hirsh J, 1989. Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory element. Genes Dev 3:1130-1145.
8. Bray SJ, Johnson WA, Hirsh J, Heberlem U, and Tjian R, 1988. A cis-acting element and associated binding factor required for CNS expression of the Drosophila melanogaster dopa decarboxylase gene. EMBO J 7 177-188.
9. Brown CS and Nestler C, 1985. Catecholamines and indolalkylamines. In: Comparative insect physiology, biochemistry and pharmacology, vol. 11 (Kerkut GA and Gilbert LI, eds). New York Pergamon; 435-496.
10. Buchner E, 1991. Genes expressed in the adult brain of Drosophila and effects of their mutations on behavior: a survey of transmitter- and second messenger-related genes. J Neurogenet 7:153-192.
11. Budnik V and White K, 1987. Genetic dissection of dopamine and serotonin synthesis in the nervous system of Drosophila melanogaster J Neurogenet 4.309-314.
12. Budnik V and White K, 1988. Catecholamine-containing neurons in Drosophila melanogaster: distribution and development. J Comp Neurol 268:400-413.
13. Budnik V, Martin-Morris L, and White K, 1986. Perturbed pattern of catecholamine-containing neurons in mutant Drosophila deficient in the enzyme dopa decarboxylase. J Neurosci 6:3682-3691.
14. Budnik V, Wu C-F, and White K, 1989. Altered branching of serotonin-containing neurons in Drosophila mutants unable to synthesize serotonin and dopamine. J Neurosci 9:2866-2877.
15. Burg MG, Sarthy PV, Koliantz G, and Pak WL, 1993. Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis. EMBO J 12:911-919.
16. Clark WC, Doctor J, Fristrom JW, and Hodgetts RB, 1986. Differential response of the Dopa Decarboxylase gene to 20-OH-ecdysone in Drosophila melanogaster. Dev Biol 114:141-150
17. Cooper JR, Bloom FE, and Roth RH, 1991. The biochemical basis of neuropharmacology, 6th ed. New York: Oxford University Press.
18. 1 phenol oxidase of Drosophila Genome 31:192.
19. Estelle MA and Hodgetts RB, 1984a. Genetic elements near the structural gene modulate the level of dopa decarboxylase during Drosophila development. Mol Gen Genet 195:434-441.
20. Estelle MA and Hodgetts RB, 1984b. Insertion polymorphisms may cause stage specific variation in mRNA levels for dopa decarboxylase in Drosophila. Mol Gen Genet 195:442-451
21. Eveleth DD and Marsh JL, 1986a. Sequence and expression of the Cc gene, a member of the dopa decarboxylase cluster of Drosophila: possible translational regulation. Nucleic Acids Res 14:6169-6183.
22. Eveleth DD and Marsh JL, 1986b Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila. Genetics 114:469-483.
23. Eveleth DD and Marsh J, 1987. Overlapping transcription units in Drosophila: sequence and structure of the Cs gene. Mol Gen Genet 209:290-298.
24. Freeman ME, 1989. The molecular organization of the distal gene subcluster in the Dopa Decarboxylase region of Drosophila melanogaster (PhD dissertation). Charlottesville: University of Virginia.
25. Fristrom D and Fristrom JW, 1993 The metamorphic development of the adult epidermis. In: The development of Drosophila melanogaster (Bate M and Martinez-Arias A, eds). Plainview. New York: Cold Spring Harbor Press; 843-897.
26. Geiger HR and Mitchell HK, 1966. Salivary gland function in phenol oxidase production in Drosophila melanogaster. J Insect Physiol 12:747-754.
27. Gietz RD and Hodgetts RB, 1985. An analysis of Dopa Decarboxylase expression during embryogenesis in Drosophila melanogaster Dev Biol 107:142-155.
28. Gilbert D and Hirsh J, 1981. The Dopa Decarboxylase gene locus of Drosophita melanogaster orientation of the gene and preliminary mapping of genetic markers. In: Developmental biology using purified genes (Brown DD, ed). New York: Academic Press; 11-16.
29. Gilbert D, Hirsh J, and Wright TRF, 1984 Molecular mapping of a gene cluster flanking the Drosophila dopa decarboxylase gene. Genetics 106:679-694.
30. Hankins GR, 1991. Analysis of a Drosophila neuroblastoma gene (PhD dissertation) Charlottesville: University of Virginia.
31. Harper RA and Armstrong FB, 1974. Alkaline phosphatase of Drosophila melanogaster. III. Tyrosine-O-phosphate as a substrate. Biochem Genet 11:177-180.
32. Hepburn HR, 1985. Structure of the integument. In: Comparative insect physiology, biochemistry and pharmacology, vol. 3 (Kerkut GA and Gilbert LI, eds). New York. Pergamon, 1-58.
33. Hirsh J, 1989. Molecular genetics of Dopa Decarboxylase and biogenic amines in Drosophila. Dev Genet 10: 232-238.
34. Hirsh J and Davidson N, 1981. Isolation and characterization of the Dopa Decarboxylase gene of Drosophila melanogaster. Mol Cell Biol 1:475-485.
35. Hirsh J, Morgan B, and Scholnick S, 1986. Delimiting regulatory sequences of the Drosophila melanogaster Ddc gene. Mol Cell Biol 6:4548-4557
36. Hodgetts RB, 1975. The response of Dopa Decarboxylase activity to variations in gene dosage in Drosophila. a possible location of the structural gene Genetics 79: 45-54.
37. Hodgetts RB, Clark WC, Gietz RD, Sage BA, and O'Conner JD, 1986. Stage-specific mechanisms regulate the expression of the Dopa Decarboxylase gene during Drosophila development Arch Insect Biochem Physiol Suppl 1.97-104.
38. Hopkins TL and Kramer KJ, 1992. Insect cuticle sclerotization. Annu Rev Entomol 24:127-222.
39. Huntley MD, 1978. The genetics of catecholamine metabolizing enzymes in Drosophila melanogaster (PhD dissertation). Charlottesville: University of Virginia.
40. Jackson FR, 1990. Prokaryotic and eukaryotic pyridoxal-dependent decarboxylases are homologous J Mol Evol 31:325-329.
41. Johnson WA and Hirsh J, 1990. Binding of a Drosophita POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons. Nature (Lond) 343:467-470.
42. Johnson WA, McCormick CA, Bray SJ, and Hirsh J, 1989 A neuron specific enhancer of the Drosophila dopa decarboxylase gene. Genes Dev 3:676-686.
43. Konrad KD and Marsh JL, 1987. Developmental expression and spatial distribution of Dopa Decarboxylase in Drosophila Dev Biol 122:172-185.
44. Konrad KD, Wang D, and Marsh JL, 1993. Vitelline membrane biogenesis in Drosophila requires the activity of the alpha-methyl dopa hypersensitive gene (l(2)amd) in both the germline and follicle cells. Insect Mol Biol 1:179-187.
45. Kraminsky GP, Clark WC, Estelle MA, Gietz RD, Sage BA, O'Conner JD, and Hodgetts RB, 1980. Induction of translatable mRNA for dopa decarboxylase in Drosophila: an early response to ecdysterone Proc Natl Acad Sci USA 77:4175-4179.
46. Kullman J, 1989. A molecular genetic characterization of the proximal gene subcluster in the Dopa Decarboxylase region of Drosophila melanogaster (PhD dissertation). Charlottesville: University of Virginia.
47. Lindsley DL, Sandler L, Baker BS, Carpenter ATC, Denell RE, Hall JC, Jacobs PA, Miklos GLG, Davis BK, Gethmann RW, Hardy RW, Hessler A, Miller SM, Nozawa H, Parry DM, and Gould-Somero M, 1972. Segmental aneuploidy and the genetic gross structure of the Drosophila genome. Genetics 71:157-184.
48. Lindsley DL and Zimm GG, 1992. The genome of Drosophila melanogaster. San Diego: Academic Press.
49. Livingstone MS and Tempel BL, 1983. Genetic dissection of monoamine neurotransmitter synthesis in Drosophila Nature (Lond) 303:67-70.
50. Lunan KD and Mitchell HK, 1969. The metabolism of tyrosine-O-phosphate in Drosophila. Arch Biochem Biophys 132:450-456.
51. Lundell M and Hirsh J, 1994. Regulation of the dopa decarboxylase gene during Drosophila development. Adv Dev Biochem 3:55-86.
52. Marsh JL, Erfle MP, and Leeds CA, 1986. Molecular localization, developmental expression and nucleotide sequence of the alpha-methyldopa hypersensitive gene of Drosophila Genetics 114:453-467.
53. Marsh JL, Gibbs PDL, and Timmons PM, 1985. Developmental control of transduced dopa decarboxylase genes in D melanogaster Mol Gen Genet 198:393-403.
54. Marsh JL and Wright TRF, 1980. Developmental relationship between dopa decarboxylase, dopamine acetyltransferase, and ecdysone in Drosophila. Dev Biol 80:379-387.
55. Marsh JL and Wright TRF, 1986. Evidence for regulatory variants of the dopa decarboxylase and alpha methyl dopa hypersensitive loci in Drosophila. Genetics 112: 249-265
56. Martinez-Arias A, 1993. Development and patterning of the larval epidermis of Drosophila. In: The development of Drosophila melanogaster (Bate M and Martinez-Arias A. eds). Plainview, New York: Cold Spring Harbor Press; 517-608.
57. McClung JK, King RL, Walker LS, Danner DB, Nuell MJ, Stewart DA, and Dell'Orco RT, 1992. Expression of prohibitin, an antiproliferative protein. Exp Gerontol 27: 413-417.
58. McCrady E and Tolin DJ, 1994. Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila J Exp Zool 268.469-476.
59. Morgan B, Johnson WA, and Hirsh J, 1986. Regulated splicing produces different forms of dopa decarboxylase in the central nervous system and hypoderm of Drosophila melanogaster EMBO J 5:3335-3342.
60. Nagatsu T, 1973 Biochemistry of catecholamines. Baltimore: University Park Press.
61. Neckameyer WS and White K, 1993. Drosophila tyrosine hydroxylase is encoded by the pale locus. J Neurogenet 8:189-199
62. Nuell MJ, Stewart DA, Walker L, Friedman V, Wood CM, Owens GA, Smith JR, Schneider EL, Dell'Orco R, Lumpkin CK, Danner DB, and McClung JK, 1991. Prohibitin, an evolutionary conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells Mol Cell Biol 11.1372-1381
63. Pearlson NJ, 1991 The molecular genetics of l(2)37Bd (MS thesis) Chariottesville: University of Virginia.
64. Pentz ES, Black BC, and Wright TRF, 1986. A diphenol oxidase gene is part of a cluster of genes in catecholamine metabolism and sclerotization in Drosophila. I. Identification of the biochemical defect in Dox-A2 [l(2)37Bf] mutants. Genetics 112:823-841.
65. Pentz ES, Black BC, and Wright TRF, 1990. Mutations affecting phenol oxidase activity in Drosophila: quick-silver and tyrosinase-1 Biochem Genet 28:151-171.
66. Pentz ES and Wright TRF, 1986. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the DOX-A2 coding region. Genetics 112:843-849.
67. - transplantation antigen, P91A. Gene 103:239-242.
68. Pichon Y and Manaranche R, 1985. Biochemistry of the nervous system In: Comparative insect physiology, biochemistry and pharmacology (Kerkut GA and Gilbert LI, eds). New York; Pergamon; 10:417-450.
69. Restifo LL and White K, 1990. Molecular and genetic approaches to neurotransmitter and neuromodulator systems in Drosophila. Adv Insect Physiol 22:115-219.
70. Rizki TM, Rizki RM, and Bellotti RA, 1985. Genetics of Drosophila phenoloxidase Mol Gen Genet 201:7-13.
71. Sato T, Saito H, Swensen J, Olifant A, Wood C, Danner D, Sakamoto T, Takita K, Kasumi F, Miki Y, Skolnick M, and Nakamura Y, 1992. The human prohibitin gene located on Chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res 52:1643-1646.
72. Scholnick SB, Bray SJ, Morgan BA, McCormick CA, and Hirsh J, 1986. Distinct central nervous system and hypoderm regulatory elements of the Drosophila melanogaster dopa decarboxylase gene. Science 234:998-1002.
73. Scholnick SB, Morgan BA, and Hirsh J, 1983. The cloned Dopa Decarboxylase gene is developmentally regulated when reintegrated into the Drosophila genome. Cell 34: 37-45.
74. Seybold WD, Meltzer PS, and Mitchell HK, 1975. Phenol oxidase activation in Drosophila: a cascade of reactions. Biochem Genet 13:85-108.
75. Shaaya E and Sekeris CE, 1965 Ecdysone during insect development. III Activities of some enzymes of tyrosine metabolism in comparison with ecdysone titer during the development of the blowfly, Calliphora erythrocephala Meig. Gen Comp Endocrinol 5.35-39.
76. Shen J, Beall CJ, and Hirsh J, 1993. Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock Mol Cell Biol 13:4549-4555.
77. Shen J and Hirsh J, 1994 cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene. Mol Cell Biol 14.7385-7393.
78. Sherald AF and Wright TRF, 1974 The analog inhibitor, α-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase in Drosophila melanogaster Mol Gen Genet 133:25-36
79. Sparrow JC and Wright TRF, 1974 The selection for mutants in Drosophila melanogaster hypersensitive to α-methyl dopa, a dopa decarboxylase inhibitor. Mol Gen Genet 130:127-141.
80. Spencer CA, Gietz RD, and Hodgetts RB, 1986a. Analysis of the transcription unit adjacent to the 3′-end of the DOPA decarboxylase gene in Drosophila melanogaster Dev Biol 114:260-264.
81. Spencer CA, Gietz RD, and Hodgetts RB, 1986b. Overlapping transcription units in the dopa decarboxylase region of Drosophita Nature (Lond) 322.279-281.
82. Stathakis DG, Pentz ES, Freeman M, Kullman J, Hankins GR, Pearlson NJ, and Wright TRF, 1995. The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster Genetics 141:629-655.
83. Steward R, McNally FJ, and Schedl P, 1984. Isolation of the dorsal locus of Drosophila. Nature (Lond) 311:262-265.
84. Valles AM and White K, 1986. Development of the neurons committed to serotonin differentiation in mutant Drosophila unable to synthesize serotonin. J Neurosci 6:1482-1491
85. Valles AM and White K, 1988. Serotonin-containing neurons in Drosophila melanogaster development and distribution. J Comp Neurol 268:414-428.
86. Valles AM and White K, 1990. Serotonin synthesis and distribution in Drosophila Dopa Decarboxylase genetic mosaics J Neurosci 10:3646-3652.
87. Walter MF, Black BC, Afshar G, Kermabon A-Y, Wright TRF, and Biessmann H, 1991. Temporal and spatial expression of the yellow gene in correlation with cuticle formation and DOPA decarboxylase activity in Drosophila development Dev Biol 147:32-45.
88. Wang D and Marsh JL, 1995. Developmental regulation of the α-methyldopa hypersensitive gene of Drosophila melanogaster. Dev Biol 168:598-612.
89. Warner CK, Grell EH, and Jacobson KB, 1975. Mechanism of suppression in Drosophila: phenol oxidase activity and the speck locus. Biochem Genet 13:353-357
90. Wright TRF, 1977. The genetics of dopa decarboxylase and α-methyl dopa sensitivity in Drosophila melanogaster Am Zool 17:707-721.
91. tsl, on viability, fertility, and dopa decarboxylase activity and thermostability in Drosophila melanogaster In: International Conference on Molecular and Developmental Biology of Insects. Heraclion, Crete, Greece, July 12-16, 1978. Hellenic Society for Biological Sciences. 43.
92. Wright TRF, 1987a. The genetics of biogenic amine metabolism, sclerotization and melanization in Drosophila melanogaster. Adv Genet 24.127-222.
93. Wright TRF, 1987b. The genetic and molecular organization of the dense cluster of functionally related, vital genes in the dopa decarboxylase region of the Drosophila melanogaster genome. In: Structure and function of eukaryotic chromosomes. Results and problems in cell differentiation (Hennig W, ed). New York: Springer; 14:95-120.
94. Wright TRF, Beermann W, Marsh JL, Bishop CP, Steward R, Black BC, Tomsett AD, and Wright EV, 1981b. The genetics of dopa decarboxylase in Drosophila melanogaster IV. The genetics and cytology of the 37B10-37D1 region Chromosoma (Berlin) 83:45-58
95. Wright TRF, Bewley GC, and Sherald AF, 1976a. The genetics of dopa decarboxylase in Drosophila melanogaster II. Isolation and characterization of dopa decarboxylase deficient mutant and their relationship to the α-methyl dopa hypersensitive mutants. Genetics 84:287-310.
96. Wright TRF, Black BC, Bishop CP, Marsh JL, Pentz ES, Steward R, and Wnght EY, 1982. The genetics of dopa decarboxylase in Drosophila melanogaster V. Ddc and l(2)amd alleles isolation, characterization and intragenic complementation. Mol Gen Genet 188:18-26.
97. Wright TRF, Hodgetts RB, and Sherald AF, 1976b. The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies of the dopa decarboxylase dosage sensitive region and the α-methyl dopa hypersensitive locus. Genetics 84: 267-285.
98. Wright TRF, Steward R, Bentley KW, and Adler PN, 1981a. The Genetics of dopa decarboxylase in Drosophila melanogaster. III. Effects of a temperature sensitive dopa decarboxylase deficient mutation on female fertility. Dev Genet 2:223-235
99. n, in Drosophila melanogaster In: XIV International Congress of Genetics. Contributed Paper Sessions Abstracts, Part I, Continuation Sections 13-20. Moscow; 615.