Will we ever have an effective pharmacotherapy for obstructive sleep apnea?

Sleep

Volumn 28, Issue 1, 2005, Pages 18-19

  Veasey, Sigrid Carlen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MIRTAZAPINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT;

BREATHING; DOSE RESPONSE; EDITORIAL; HYPOGLOSSAL NERVE; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RESPIRATION CONTROL; SLEEP; SLEEP APNEA SYNDROME; BLOOD BRAIN BARRIER; DRUG EFFECT; HUMAN; NODOSE GANGLION; NOTE; REM SLEEP; VAGUS NERVE;

ADRENERGIC ALPHA-ANTAGONISTS; BLOOD-BRAIN BARRIER; HUMANS; NODOSE GANGLION; SLEEP APNEA, OBSTRUCTIVE; SLEEP, REM; VAGUS NERVE;

EID: 17244364685     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (23)

1. Berry RB, Koch G, Hayward LF. Low dose mirtazapine increases genioglossus activity in the anesthetized rat. Sleep 2005;28(1)78-84.
2. Kubin L, Tojima H, Davies RO, Pack AI. Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neuroscience Letters. 139(2):243-8, 1992
3. Sood S, Liu X, Liu H, Nolan P, Horner RL. 5-HT at hypoglossal motor nucleus and respiratory control of genioglossus muscle in anesthetized rats. Respiratory Physiology & Neurobiology. 138:205-21, 2003.
4. Y, Kodama T, Siegel JM. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J Neurosci 21:7384-91, 2001.
5. Veasey SC, Panckeri KA, Hoffman EA, Pack AI, Hendricks JC. The effects of serotonin antagonists in an animal model of sleep-disordered breathing. Am J Respir Crit Care Med 153:776-86, 1996.
6. Jelev A, Sood S, Liu H, Nolan P, Horner RL. Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol. 532:467-81, 2001.
7. Kubin L, Reignier C, Tojima H, Taguchi O, Pack AI, Davies RO. Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain Research. 645:291-302, 1994.
8. Kubin L, Tojima H, Reignier C, Pack AI, Davies RO. Interaction of serotonergic excitatory drive to hypoglossal motoneurons with carbachol-induced, REM sleep-like atonia. Sleep. 19:187-95, 1996.
9. Fenik V, Davies RO, Kubin L. Combined antagonism of aminergic excitatory and amino acid inhibitory receptors in the XTT nucleus abolishes REM sleep-like depression of hypoglossal motoneuronal activity. Arch Italiennes de Biologie. 142:237-49, 2004.
10. Zhan G, Shaheen F, Mackiewicz M, Fenik P, Veasey SC. Single cell laser dissection with molecular beacon polymerase chain reaction identifies 2A as the predominant serotonin receptor subtype in hypoglossal motoneurons. Neuroscience. 113:145-54, 2002.
11. Fenik P, Veasey SC. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J Respir Crit Care Med 167:563-9, 2003.
12. Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K. Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Critical Reviews in Neurobiology. 12:319-38, 1998.
13. Moss IR. Maturation of respiratory control in the behaving mammal. Respiratory Physiology & Neurobiology. 132:131-44, 2002.
14. Richter DW, Manzke T, Wilken B, Ponimaskin E. Serotonin receptors: guardians of stable breathing. Trends in Molecular Medicine. 9:542-8, 2003.
15. Sutton PM. The interaction between reflex apnoea and bradycardia produced by injecting 5-HT into the nodose ganglion of the cat. Pflugers Archiv - European Journal of Physiology. 389:181-7, 1981.
16. Radulovacki M, Pavlovic S, Saponjic J, Carley DW. Intertrigeminal region attenuates reflex apnea and stabilizes respiratory pattern in rats. Brain Research. 975:66-72, 2003.
17. Yoshioka M, Goda Y, Togashi H, Matsumoto M, Saito H. Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. J Pharm Exper Therapeut. 260:917-24, 1992.
18. Radulovacki M, Trbovic SM, Carley DW. Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats. Sleep. 21:131-6, 1998.
19. Veasey SC, Chachkes J, Fenik P, Hendricks JC. The effects of ondansetron on sleep-disordered breathing in the English bulldog. Sleep. 24:155-60, 2001.
20. Lalley PM, Bischoff AM, Richter DW. Serotonin 1A-receptor activation suppresses respiratory apneusis in the cat. Neuroscience Letters. 172:59-62, 1994.
21. Wilken B, Lalley P, Bischoff AM, Christen HJ, Behnke J, Hanefeld F, Richter DW. Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist. J of Pediatrics. 130:89-94, 1997.
22. Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW. 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science. 301:226-9, 2003.
23. Okabe S, Kubin L. Role of 5HT1 receptors in the control of hypoglossal motoneurons in vivo. Sleep. 19:S150-3, 1996.