Bradykinin antagonists in human systems: Correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum

Biochemical Pharmacology

Volumn 54, Issue 2, 1997, Pages 283-291

  Wieczorek, Maciej ^a   Pilyavskaya, Anna ^a   Burkard, Michael ^a   Zuzack, John S ^a   Jones, Steven W ^a,c   Francis, Mary D ^a,d   Beckey, Virginia E ^a   Ross, Sherman E ^a   Goodfellow, Val S ^a   Fitzpatrick, Timothy D ^a,e   Marathe, Manoj V ^a   Gyorkos, Albert ^a   Spruce, Lyle W ^a   Selig, William M ^a   Stewart, John M ^b   Gera, Lajos ^b   Whalley, Eric T ^a  

^a Departments of New Leads Chemistry and Pharmacology   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d Cadus Pharmaceutical Corporation   (United States)

^e Synthetech   (United States)

Author keywords

B2 receptor; Bradykinin antagonists; Calcium flux; Human ileum

Indexed keywords

BRADYKININ ANTAGONIST; BRADYKININ B2 RECEPTOR; BRADYKININ RECEPTOR AGONIST;

ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM CONTRACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BRADYKININ; CALCIUM; DIHYDROMORPHINE; HUMANS; ILEUM; RECEPTORS, BRADYKININ; SIGNAL TRANSDUCTION;

EID: 17144475047     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00186-X     Document Type: Article

References (37)

1. Regoli D and Barabé J, Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1-46, 1980.
2. Hall JM, Bradykinin receptors: Pharmacological properties and biological roles. Pharmacol Ther 56: 131-190, 1992.
3. Farmer SG and Burch RM, Biochemical and molecular pharmacology of kinin receptors. Annu Rev Pharmacol Toxicol 32: 511-536, 1992.
4. Vavrek RJ and Stewart JM, Competitive antagonists of bradykinin. Peptides 6: 161-164, 1985.
5. Stewart JM and Vavrek RJ, Chemistry of peptide B2 bradykinin antagonists. In: Bradykinin Antagonists (Ed. Burch RM), pp. 51-96. Marcel Dekker, New York, 1991.
6. Bathon JM and Proud D, Bradykinin antagonists. Annu Rev Pharmacol Toxicol 31: 129-162, 1991.
7. Stewart JM, Gera L, Hanson W, Zuzack JS, Burkard M, McCullough R and Whalley ET, A new generation of bradykinin antagonists, Immunopharmacology 33: 51-60, 1996.
8. Burch RM, Kyle DJ and Stormann TM, Molecular Biology Intelligence Unit. Molecular Biology and Pharmacology of Bradykinin Receptors. R.G. Landes Co., Austin, 1993.
9. 7 substituted bradykinin analogues. Eur J Pharmacol (Mol Pharmacol) 227: 309-315, 1992.
10. 2 receptor antagonist. Proc Nad Acad Sci USA 91: 4693-4697, 1994.
11. 2+ stores. J Biol Chem 267: 108-118, 1992.
12. McAllister BS, Leeb-Lundberg MF, Javors MA and Olson MS, Bradykinin receptors and signal transduction pathways in human fibroblasts: Integral role for extracellular calcium. Arch Biochem Biophys 304: 294-301, 1993.
13. Hess JF, Borkowski JA, Young GS, Strader CD and Ransom RW, Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. Biochem Biophys Res Commun 184: 260-268, 1992.
14. Eggerickx D, Raspe E, Bertrand D, Vassart G and Parmentier M, Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. Biochem Biophys Res Commun 187: 1306-1313, 1992.
15. Powell SJ, Slynn G, Thomas C, Hopkins B, Briggs I and Graham A, Human bradykinin B2 receptor: Nucleotide sequence analysis and assignment to chromosome 14. Genomics 15: 435-438, 1993.
16. Murray RK and Kotlikoff MI, Receptor-activated calcium influx in human airway smooth muscle cells. J Physiol (Lond) 435: 123-144, 1991.
17. Bathon JM, Croghan JC, MacGlashan DW Jr and Proud D, Bradykinin is a potent and relatively selective stimulus for cytosolic calcium elevation in human synovial cells. J Immunol 153: 2600-2608, 1994.
18. 2+ store depletion? Mol Pharmacol 47: 509-516, 1995.
19. 2+ transient in vascular smooth muscle cells in coculture. J Biol Chem 271: 5647-5655, 1996.
20. Hulme EC and Birdsall NJM, Strategy and tactics in receptor-binding studies. In: Receptor-Ligand Interactions. A Practical Approach (Ed. Hulme EC), pp. 63-174. Oxford University Press, Oxford, 1992.
21. Chirgwin JM, Przybyla AE, MacDonald RJ and Rutter WJ, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18: 5294-5299, 1979.
22. Maniatis T, Fritsch EF and Sambrook J, Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1982.
23. Kunkel T, Roberts J and Zakour R, Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154: 367-382, 1987.
24. 1 receptor antagonist activity. J Med Chem 39: 1472-1484, 1996.
25. 2 bradykinin receptors from cultured human fibroblasts. J Biol Chem 266: 9442-9446, 1991.
26. Hallett MB, Dormer RL and Campbell AK, Cytoplasmic free calcium: Measurement and manipulation in living cells. In: Peptide Hormone Action. A Practical Approach (Eds. Siddle K and Hutton JC), pp. 115-150. Oxford University Press, New York, 1990.
27. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
28. Arunlakshana O and Schild HO, Some quantitative uses of drug antagonists. Br J Pharmacol 14: 48-58, 1959.
29. De Lean A, Munson PJ and Rodbard D, Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves. Am J Physiol 235: E97-E102, 1978.
30. 2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons. J Biol Chem 270: 13706-13710, 1995.
31. 2 receptor characterization. Trends Pharmacol Sci 11: 156-161, 1990.
32. 1 receptor antagonist, FK888. Br J Pharmacol 107: 785-789, 1992.
33. Hock FJ, Wirth K, Albus U, Linz W, Gerhards HJ, Wiemer G, Henke St, Breipohl G, König W, Knolle J and Schölkens BA, Hoe 140 a new potent and long acting bradykinin-antagonist: In vitro studies. Br J Pharmacol 102: 769-773, 1991.
34. Hanson WL, McCullough RG, Selig WM, Wieczorek M, Ross S, Whalley ET, Stewart JM and Gera L, In vivo pharmacological profile of novel, potent, stable BK antagonists at B1 and B2 receptors. Immunopharmacology 33: 191-193, 1996.
35. 2 bradykinin receptor reveal a different pattern of contacts for peptidic agonists and peptidic antagonists. J Biol Chem 271: 28277-28286, 1996.
36. Cuba W, Haessner R, Breipohl R, Henke S, Knolle J, Santagada V and Kessler H, Combined approach of NMR and molecular dynamics within a biphasic membrane mimetic: Conformation and orientation of the bradykinin antagonist Hoe 140. J Am Chem Soc 116: 7532-7540, 1994.
37. Alla SA, Quitterer U, Grigoriev S, Maidhof A, Haasemann M, Jarnagin K and Müller-Esterl W, Extracellular domains of the bradykinin B2 receptor involved in ligand binding and agonist sensing defined by anti-peptide antibodies. J Biol Chem 271: 1748-1755, 1996.