α2 Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydrothianaphtheneas a high-affinity ligand for the α(2D) adrenergic receptor [1]

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 765-768

  Ross, Tina M ^a   Jetter, Michele C ^a   McDonnell, Mark E ^a   Boyd, Robert E ^a   Connelly, Charlene D ^a   Martinez, Rebecca P ^a   Lewis, Martin A ^a   Codd, Ellen E ^a   Raffa, Robert B ^b   Reitz, Allen B ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 (4 IMIDAZOLYL)BENZO[B]THIOPHENE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; BENZOTHIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; LETTER; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; ANALGESICS, NON-NARCOTIC; ANIMALS; BINDING, COMPETITIVE; CELL LINE; IMIDAZOLES; MICE; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 17144439079     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990569e     Document Type: Letter

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