Dexmedetomidine: A general overview

International Congress and Symposium Series - Royal Society of Medicine

Volumn , Issue 221, 1998, Pages 11-22

  Duke, Peter ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002783670     PISSN: 01422367     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (30)

1. Shafer A. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Crit Care Med 1998; 26: 947-56.
2. Grippen DW. The role of sedation in the ICU patient with pain and agitation. Crit Care Clm 1990; 6: 369-92.
3. Shelly MP, Sultan MA, Bodenham A, Park GR. Midazolam infusions in critically ill patients. EurJ Anaesthesiol 1991; 8: 21-7.
4. Reisine T, Pasternak G. Opioid analgesics and antagonists. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Eds. Tbc pharmacological basis of therapeutics, 9th ed. London: McGraw-Hill; 1996: 521-33.
5. Hayashi Y, Maze M. 2-adrenoceptor agonists and anaesthesia. BrJ Anaestb 1993; 71: 108-18.
6. LomasneyJW, Cotecchia S, Lefkowitz RJ, Caron MG. Molecular biology of ot-adrenergic receptors: implications for receptor classification and for structure-function relationships. Biocbim Biopbys Acta 1991; 109S: 127-39.
7. Link RE, Desai K, Hein L et al. Cardiovascular regulation in mice lacking j-adrenergic receptor subtypes b and c. Science 1996; 273: 803-5.
8. Ganong WF. Review of medical physiology, 17th ed. Norwalk, CT: Appleton & Lange; 1995: 206-7.
9. Ghignone M, Quintin L, Duke PC et al. Effects of clonidine on narcotic requirements and haemodynamic response during induction of fentanyl anaesthesia and endotracheal intubation. Anexhesialo 1986; 64: 36-42.
10. Quintin L, Roudot R, Roux C et al. Effect of clonidine on the circulation and vasoactive hormones after aortic surgery. Br J Anacstb 1991; 66: 108-15.
11. Mangano DT, Layug EL, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N EnglJ Med 1996; 335: 1713-20.
12. Mangano DT. Cardiac anaesthesia risk management. Multicenter outcome research. J Cardiotborac Vase Anestb 1994; 8 (suppl 1): 10-12.
13. Dorman BH, Zucker JR, Verrier ED et al. Clonidine improves perioperative myocardial ischaemia, reduces anaesthetic requirement and alters haemodynamic parameters in patients undergoing coronary artery bypass surgery. J Cardiothorac Vase Anetth 1993; 7: 386-95.
14. Aanta R, Kallio A, Virtanen R. Dexmedetomidine, a novel a2-adrenergic agonist: a review of its pharmacodynamic characteristics. Drugs of the Future 1993; 18: 49-56.
15. Aantaa R, Jaakola M-L, Kallio A a al. A comparison of dexmedetomidine, an a.2adrenoceptor agonist and midazolam as i.m. premedication for minor gynaecological surgery. BrJAnaesth 1991; 67: 402-9.
16. Aantaa R, Kanto J, Scheinin M et al. Dexmedetomidine, an a2-adrenoceptor agonist, reduces anaesthetic requirements for patients undergoing minor gynecological surgery. Anestbetiology 1990; 73: 230-5.
17. Jaakola M-L, Ali-Melkkilä T, Kanto J et al. Dexmedetonudine reduces intraocular pressure, intubation responses and anaesthetic requirements in patients undergoing ophthalmic surgery. BrJAnaestb 1992; 68: 570-5.
18. Scheinin H, Jaakola MJ, Sjövall S et at. Intramuscular dexmedetomidine as premedication for general anaesthesia. A comparative multicenter study. Anestbesiology 1993; 78: 1065-75.
19. Maxwell C. Sensitivity and accuracy of the visual analogue scale: a psychophysical classroom experiment. Br J Clin Pbarmacol 1978; 6: 15-24.
20. Aho M, Scheinin M, Lehtinen A-M et al. Intramuscularly administered dexmedetomidine attenuates hemodynamic and stress hormone responses to gynecologic laparoscopy. Anestb Analg 1992; 75: 932-9.
21. Jaakola ML. Dexmedetomidine premedication before intravenous regional anaesthesia in minor outpatient hand surgery. J Clin Anesth 1994; 6: 204-11.
22. Aho MS, Erkola OA, Scheinin H et al. Effect of intravenously administered dexmedetomidine on pain after laparoscopic tubal ligaoon. Anestb Analg 1991; 73: 112-18.
23. Scheinin B, Lindgren L, Randell T et al. Dexmedetomidine attenuates sympathoadrenal responses to tracheal intubation and reduces the need for thiopentone and peroperative fentanyl. BrJAnaestb 1992; 68: 126-31.
24. Talke P, Li J, Jain U et al. Effects of perioperative dexmedetomidine infusion in patients undergoing vascular surgery. Anaesthesia 1995; 82: 620-33.
25. Talke P, Mangano DT, Li J rt al. Effect of dexmedetomidine on myocardial ischaemia in vascular surgery patients: a safety and dose escalation study. Anestbesiology 1993; 79(3A): A60.
26. Heikkilä H, Jalonen J, Hynynen M et at. Dexmedetomidine infusion and perioperative ischaemia in patients undergoing coronary artery bypass surgery. J Cardiothor and Vase Anesth 1994; 8(suppl 3): 54.
27. Erkola O, Kortrila K, Aho M et al. Comparison of intramuscular dexmedetomidine and midazolam premedicauon for elective abdominal hysterectomy. Amsth Analg 1994; 79: 646-53.
28. Anfossi G, Trovatj M. Role of catecholamines in platelet function: pathophysiological and clinical significance. Eur J Clin Invest 1996; 26: 353-70.
29. Rosenfeld BA, Faraday N, Campbell D et al Perioperative platelet reactivity and the effects of clonidine. Anesthesiology 1993; 79: 255-61.
30. Steen VM, Holmsen H, Aarbakke G. The platelet-stimulating effect of adrenaline through 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. Thromb Haemost 1993; 70: 506-13.