Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6- yl)imino]imidazoline, a potent, peripherally acting α2 adrenoceptor agonist

Journal of Medicinal Chemistry

Volumn 39, Issue 18, 1996, Pages 3533-3538

  Munk, Stephen A ^a   Harcourt, Dale ^a   Ambrus, György ^a   Denys, Lydia ^a   Gluchowski, Charles ^a   Burke, James A ^a   Kharlamb, Alexander B ^a   Manlapaz, Cynthia A ^a   Padillo, Edwin U ^a   Runde, Eileen ^a   Williams, Linda ^a   Wheeler, Larry A ^a   Garst, Michael E ^a  

^a ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGN 191103; AGN 192172; AGN 193080; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; APRACLONIDINE; CLONIDINE; OCTANOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE RESPONSE; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; HYPERTENSION; INTRACISTERNAL DRUG ADMINISTRATION; INTRAOCULAR HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; TOPICAL DRUG ADMINISTRATION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; IMIDAZOLES; INTRAOCULAR PRESSURE; MALE; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9544227359     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960359r     Document Type: Article

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