Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2339-2342

  Williamson, Rachel M ^a   Pietersma, Amy L ^a   Jameson, Geoffrey B ^a   Parker, Emily J ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

3 Deoxy D arabino heptulosonate 7 phosphate; Deoxyerythrose 4 phosphate; Erythrose 4 phosphate; Shikimate

Indexed keywords

2 DEOXYERYTHROSE 4 PHOSPHATE; 3 DEOXY DEXTRO ARABINOHEPTULOSONATE 7 PHOSPHATE SYNTHASE; BACTERIAL ENZYME; DEUTERIUM; DEUTERIUM OXIDE; SHIKIMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ENANTIOMER; ENZYME MECHANISM; ESCHERICHIA COLI; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS;

ESCHERICHIA COLI;

EID: 17144408407     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.080     Document Type: Article

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24. max for PEP was used to keep absorbances within the linear range of the spectrophotometer
25. ® (8 mL bed volume) eluted with a linear gradient of 0-500 mM ammonium bicarbonate
26. Synthesis and enzyme testing of the enantiopure (3S)-2-deoxyerythrose 4-phosphate have discounted the unlikely possibility that this product arises from reaction of PEP on the si-face of (3R)-2-deoxyE4P