Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate

Journal of the American Chemical Society

Volumn 126, Issue 32, 2004, Pages 9912-9913

  Bulloch, Esther M M ^a   Jones, Michelle A ^a   Parker, Emily J ^a   Osborne, Andrew P ^a   Stephens, Elaine ^a   Davies, Gareth M ^b   Coggins, John R ^c   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 4 DEOXYCHORISMATE SYNTHASE; 6 FLUOROSHIKIMIC ACID; ANTIINFECTIVE AGENT; CHORISMIC ACID; CHORISMIC ACID SYNTHASE; SHIKIMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CATALYSIS; COVALENT BOND; DRUG POTENCY; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME PURIFICATION; ESCHERICHIA COLI; NONHUMAN;

ANTI-INFECTIVE AGENTS; CARBON-NITROGEN LIGASES; CHORISMIC ACID; ENZYME INHIBITORS; MASS SPECTROMETRY; SHIKIMIC ACID; TRANSAMINASES;

EID: 4043179710     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja048312f     Document Type: Article

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