Adenovirus-mediated expression of β-adrenergic receptor kinase C-terminus reduces intimal hyperplasia and luminal stenosis of arteriovenous polytetrafluoroethylene grafts in pigs

Circulation

Volumn 111, Issue 13, 2005, Pages 1679-1684

  Luo, Zhengyu ^a   Akita, Geoffrey Y ^a   Date, Taro ^a   Treleaven, Christopher ^a   Vincent, Karen A ^a   Woodcock, Denise ^a   Cheng, Seng H ^a   Gregory, Richard J ^a   Jiang, Canwen ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Gene therapy; Grafting; Hemodialysis; Hyperplasia; Thrombosis

Indexed keywords

ADENOVIRUS VECTOR; BETA ADRENERGIC RECEPTOR KINASE C; POLITEF; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANGIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EXPERIMENTAL MODEL; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; GRAFT PATENCY; HISTOLOGY; JUGULAR VEIN; NONHUMAN; PATHOPHYSIOLOGY; POLITEF IMPLANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; STENOSIS; SWINE; VASCULAR ACCESS; VEIN ANASTOMOSIS; VEIN GRAFT; WOUND HEALING;

ADENOVIRIDAE; ANIMALS; ARTERIOVENOUS SHUNT, SURGICAL; CATHETERS, INDWELLING; EQUIPMENT FAILURE; GENE EXPRESSION REGULATION; GRAFT OCCLUSION, VASCULAR; HYPERPLASIA; POLYTETRAFLUOROETHYLENE; RECEPTORS, ADRENERGIC, BETA; RENAL DIALYSIS; SWINE; TRANSDUCTION, GENETIC; TUNICA INTIMA;

EID: 17144394436     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000160357.80517.92     Document Type: Article

References (26)

1. USRDS. United States Renal Data System Annual Report. Minneapolis, Minn: United States Renal Data System; 2000.
2. Feldman HI, Kobrin S, Wasserstein A. Hemodialysis vascular access morbidity. J Am Soc Nephrol. 1996;7:523-535.
3. Roy-Chaudhury P, Duncan H, Barrett W, Elson H, Narayana A, Foley J, Misra S, Lynch PM, Zuckerman D. Vascular brachytherapy for hemodialysis vascular access dysfunction: exploring an unmet clinical need. J Invasive Cardiol. 2003;15(suppl A):25A-30A.
4. Roy-Chaudhury P, Kelly BS, Zhang J, Narayana A, Desai P, Melham M, Duncan H, Heffelfinger SC. Hemodialysis vascular access dysfunction: from pathophysiology to novel therapies. Blood Purif. 2003;21:99-110.
5. Swedberg SH, Brown BG, Sigley R, Wight TN, Gordon D, Nicholls SC. Intimal fibromuscular hyperplasia at the venous anastomosis of PTFE grafts in hemodialysis patients: clinical, immunocytochemical, light and electron microscopic assessment. Circulation. 1989;80:1726-1736.
6. Rekhter M, Nicholls S, Ferguson M, Gordon D. Cell proliferation in human arteriovenous fistulas used for hemodialysis. Arterioscler Thromb. 1993;13:609-617.
7. Iaccarino G, Koch WJ. G beta gamma-mediated signaling: new therapeutic target for proliferative vascular disease. IUBMB Life. 1999;48:257-261.
8. Iaccarino G, Smithwick LA, Lefkowitz RJ, Koch WJ. Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. Proc Natl Acad Sci U S A. 1999;96:3945-3950.
9. Davies MG, Huynh TT, Fulton GJ, Lefkowitz RJ, Svendsen E, Hagen PO, Koch WJ. G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. Arterioscler Thromb Vasc Biol. 1998;18:1275-1280.
10. Indolfi C, Avvedimento EV, Rapacciuolo A, Di Lorenzo E, Esposito G, Stabile E, Feliciello A, Mele E, Giuliano P, Condorelli G, et al. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nat Med. 1995;1:541-545.
11. Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem. 1998;67:653-692.
12. Asahara T, Bauters C, Pastore C, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, Isner JM. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation. 1995;91:2793-2801.
13. Indolfi C, Avvedimento EV, Rapacciuolo A, Esposito G, Di Lorenzo E, Leccia A, Pisani A, Chieffo A, Coppola A, Chiariello M. In vivo gene transfer: prevention of neointima formation by inhibition of mitogen-activated protein kinase kinase. Basic Res Cardiol. 1997;92:378-384.
14. von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ. Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. Proc Natl Acad Sci U S A. 1995;92:1137-1141.
15. Laitinen M, Zachary I, Breier G, Pakkanen T, Hakkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Yla-Herttuala S. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther. 1997;8:1737-1744.
16. Smith RC, Branellec D, Gorski DH, Guo K, Perlman H, Dedieu JF, Pastore C, Mahfoudi A, Denefle P, Isner JM, Walsh K. p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev. 1997;11:1674-1689.
17. DeYoung MB, Dichek DA. Gene therapy for restenosis: are we ready? Circ Res. 1998;82:306-313.
18. Tsui LV, Camrud A, Mondesire J, Carlson P, Zayek N, Camrud L, Donahue B, Bauer S, Lin A, Frey D, Rivkin M, Subramanian A, Falotico R, Gyuris J, Schwartz R, McArthur JG. p27-p16 fusion gene inhibits angioplasty-induced neointimal hyperplasia and coronary artery occlusion. Circ Res. 2001;89:323-328.
19. Sriram V, Patterson C. Cell cycle in vasculoproliferative diseases: potential interventions and routes of delivery. Circulation. 2001;103:2414-2419.
20. Belanger AJ, Scaria A, Lu H, Sullivan JA, Cheng SH, Gregory RJ, Jiang C. Fas ligand/Fas-mediated apoptosis in human coronary artery smooth muscle cells: therapeutic implications of fratricidal mode of action. Cardiovasc Res. 2001;51:749-761.
21. Luo Z, Garron T, Palasis M, Lu H, Belanger AJ, Scaria A, Vincent KA, Date T, Akita GY, Cheng SH, Barry J, Gregory RJ, Jiang C. Enhancement of Fas ligand-induced inhibition of neointimal formation in rabbit femoral and iliac arteries by coexpression of p35. Hum Gene Ther. 2001;12:2191-2202.
22. Rotmans JI, Velema E, Verhagen HJ, Blankensteijn JD, Kastelein JJ, de Kleijn DP, Yo M, Pasterkamp G, Stroes ES. Rapid, arteriovenous graft failure due to intimal hyperplasia: a porcine, bilateral, carotid arteriovenous graft model. J Surg Res. 2003;113:161-171.
23. Johnson MS, McLennan G, Lalka SG, Whitfield RM, Dreesen RG. The porcine hemodialysis access model. J Vasc Interv Radiol. 2001;12:969-977.
24. Jiang C, O'Connor SP, Armentano D, Berthelette PB, Schiavi SC, Jefferson DM, Smith AE, Wadsworth SC, Cheng SH. Ability of adenovirus vectors containing different CFTR transcriptional cassettes to correct ion transport defects in CF cells. Am J Physiol. 1996;271:L527-L537.
25. Kelly BS, Heffelfinger SC, Whiting JF, Miller MA, Reaves A, Armstrong J, Narayana A, Roy-Chaudhury P. Aggressive venous neointimal hyperplasia in a pig model of arteriovenous graft stenosis. Kidney Int. 2002;62:2272-2280.
26. Feldman LJ, Steg G. Optimal techniques for arterial gene transfer. Cardiovasc Res. 1997;35:391-404.