Gβγ-mediated signaling: New therapeutic target for proliferative vascular disease

IUBMB Life

Volumn 48, Issue 3, 1999, Pages 257-261

  Iaccarino, Guido ^a   Koch, Walter J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenovirus; G protein; G protein coupled receptors; Gene therapy; MAP kinase; Vascular smooth muscle

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN INHIBITOR; RAS PROTEIN; RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ARTERY INTIMA PROLIFERATION; CELL ACTIVATION; CELL PROLIFERATION; GENE THERAPY; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELL DIVISION; GENE EXPRESSION REGULATION; GENE THERAPY; GTP-BINDING PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; SIGNAL TRANSDUCTION; VASCULAR DISEASES;

ADENOVIRIDAE;

EID: 0032745198     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/152165499306937     Document Type: Review

References (44)

1. Davies, M. G., and Hagen, P. O. (1994) Pathobiology of intimal hyperplasia. Br. J. Surg. 81, 1254-1260.
2. Lynch, C. M., Hara, P. S., Leonard, J. C., Williams, J. K., Dean, R. H., and Geary, R. L. (1997) Adeno-associated virus vectors for vascular gene delivery. Circ. Res. 80, 497-505.
3. Newton, A. C. (1995) Protein kinase C: structure, function and regulation. J. Biol. Chem. 270, 28495-28498.
4. Inglese, J., Koch, W. J., Touhara, K., and Lefkowitz, R. J. (1995) Gβγ interactions with PH domains and Ras-MAPK signaling pathways. Trends Biochem. Sci. 20, 151-156.
5. van Corven, E. J., Hordijk, P. L., Medema, R. H., Bos, J. L., and Moolenar, W. H. (1993) Pertussis toxin sensitive activation of p21ras by G protein coupled receptor agonists in fibroblasts. Proc. Natl. Acad. Sci. USA 90, 1257-1261.
6. Powell, J. S., Clozel, J. P., Muller, R. K., Kuhn, H., Hefti, F., Hosang, M., and Baumgartner, H. R. ( 1989) Inhibitors of angiotensin converting enzyme prevent myointimal proliferation after vascular injury. Science 245, 186-188.
7. Clowes, A. W., and Karnowsky, M. J. (1977) Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature 265, 625-626.
8. Fuster, V., Dyken, M. L., Vokonas, P. S., and Hennekens, C. (1993) Aspirin as a therapeutic agent in cardiovascular disease. Circulation 87, 659-675.
9. O'Malley, M. K., McDermott, E., Mehigan, D., and O'Higgins, N. J. (1989) Role for prazosin in reducing the development of rabbit intimai hyperplasia after endothelial denudation. Br. J. Surg. 76, 936-938.
10. Sarembock, I. J., Gertz, S. D., Gimple, L. W., Owen, L. W., Powers, E. R., and Roberts, W. C. (1991) Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation 84, 232-243.
11. Kauffman, R. F., Bean, J. S., Zimmerman, K. M., Brown, R. F., and Steinberg, M. I. (1991) Losartan, a nonpeptide angiotensin II (AngII) receptor antagonist, inhibits neoimima formation following balloon injury to rat carotid arteries. Life Sci. 49, PL223-228.
12. Law, R. E., Meehan, W. P., Xi, X. P., Graf, K., Wuthrich, D. A., Coats, W., Faxon, D., and Hsueh, W. A. (1996) Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia. J. Clin. Invest. 98, 1897-1905.
13. The MERCATOR Study Group. (1992) Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group. Circulation 86, 100-110.
14. Serruys, P. W., Rutsch, W., Heyndrickx, G. R., Danchin, N., Mast, E. G., Wijns, W., Rensing, B. J., Vos, J., Stibbe, J. (1991) Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2-receptor blockade. A randomized, double-blind, placebo-controlled trial. Coronary Artery Restenosis Prevention on Repeated Thromboxane-Antagonism Study (CARPORT). Circulation 84, 1568-1580.
15. Serruys, P. W., Klein, W., Tijssen, J. P., Rutsch, W., Heyndrickx, G. R., Emanuelsson, H., Ball, S. G., Decoster, O., Schroeder, E., Liberman, H., et al. (1993) Evaluation of ketanserin in the prevention of restenosis after percutaneous transluminal coronary angioplasty. A multicenter randomized double-blind placebo-controlled trial. Circulation 88, 1588-1601.
16. Caron, M. G., and Lefkowitz, R. J. (1993) Catecholamine receptors: structure, function and regulation. Recent Prog. Horm. Res. 48, 277-290.
17. Hepler, J. R., and Gilman, A. G. (1992) G proteins. Trends Biochem. Sci. 17, 383-387.
18. Clapman, D. E., and Neer, E. J. (1993) New roles for G-protein, βγ dimers in transmembrane signaling. Nature 365, 403-406.
19. Koch, W. J., Hawes, B. E., Allen, L. F., and Lefkowitz, R. J. (1994) Direct evidence that Gi-coupled receptor stimulation of mitogen-activaed protein kinase is mediated by G beta gamma activation of p21ras. Proc. Natl. Acad. Sci. USA 91, 12706-12710.
20. Eguchi, S., Matsumoto, T., Motley, E. D., Utsunomiya, H., and Inagami, T. (1996) Identification of an essential signaling cascade for mitogen activated protein kinase activation by angiotensin II in cultured rat vascular smooth muscle cells. J. Biol. Chem. 271, 14169-14175.
21. Zhang, L. M., Newman, W. H., Castresana, M. R., and Hildebrandt, J. D. (1994) The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor. Endocrinology 134, 1297-1304.
22. Kanthou, C., Kanse, S. M., Kakkar, V. V., and Benzakour, O. (1996) Involvement of pertussis toxin-sensitive and -insensitive G proteins in alpha-thrombin signalling on cultured human vascular smooth muscle cells. Cell Signal 8, 59-66.
23. Blenis, J. (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. USA 90, 5889-5892.
24. Hayashida, W., Horiuchi, M., and Dzau, V. J. (1996) Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. J. Biol. Chem. 271, 21985-21992.
25. Sadoshima, J., Qiu, Z., Morgan, J. P., and Izumo, S. (1995) Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptor activate tyrosin kinase, mitogen-activated protein kinase and 90kD S6 kynase in cardiac myocytes. Circ. Res. 76, 1-15.
26. Sakanaka, C., Ferby, I., Waga, I., Bito, H., and Shimizu, T. (1994) On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogenactivated protein kinase. Biochem. Biophys. Res. Commun. 205, 18-23.
27. Wang, Y., Pouyssegur, J., and Dunn, M. J. (1993) Endothelin stimulates mitogen-activated protein kinase p-42 activity through the phosphorylation of the kinase in rat mesangial cells. J. Cardiovasc. Pharmacol. 22(Supp. 8), S164-S167.
28. Morinelli, T. A., Zhang, L .M., Newman, W. H., and Meier, K. E. (1994) Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase. J. Biol. Chem. 269, 5693-5698.
29. Knall, C., Young, S., Nick, J. A., Buhl, A. M., Worthen, G. S., and Johnson, G. L. (1995) Interleukin-8 regulation of the ras/raf/mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem. 271, 2832-2838.
30. van Biesen, T., Luttrell, L. M., Hawes, B. E., and Lefkowitz, R. J. (1996) Milogenic signaling via G protein-coupled receptors. Endocr. Rev. 17, 698-714.
31. Alblas, J., van Corven, E. J., Hordijk, P. L., Milligan, G., and Moolenar, W. H. ( 1993) Gi mediated activation of the p21ras-mitogen-activated protein kinase pathway by α2 adrenergic receptors expressed in fibroblasts. J. Biol. Chem. 268, 22235-22238.
32. Crespo, P., Xu, N., Simonds, W. S., and Gutkind, J. S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G protein-beta gamma subunits. Nature 369, 418-420.
33. Luttrell, L. M., van Biesen, T., Hawes, B. E., Koch, W. J., Touhara, K., and Lefkowitz, R. J. (1995) G βγ subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J. Biol. Chem. 270, 16495-16498.
34. Koch, W.J., Inglese, J., Stone, W.C., and Lefkowitz, R.J. ( 1993) The binding site for the βγ subunits of heterotrimeric G proteins on the β-adrenergic receptor kinase. J. Biol. Chem. 268, 8256-8260.
35. Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M., and Lefkowitz, R. J. (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling. J. Biol. Chem. 269, 6193-6197.
36. βγ inhibitor suggests a major role of G-protein signaling in lesion development. Arterioscler. Thromb. Vasc. Biol. 18, 1275-1280.
37. Drazner, M. H., Peppel, K. C., Dyer, S., Grant, A. O., Koch, W. J., and Lefkowitz, R. J. ( 1997) Potentiation of β adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. J. Clin. Invest. 99, 288-296.
38. βγ signaling limits the development of vein graft intimal hyperplasia. Surgery 124, 177-186.
39. Iaccarino, G., Smithwick, L. A., Lefkowitz, R. J., and Koch, W. J. (1999) Targeting G beta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. Proc. Natl. Acad. Sci. USA 96, 3945-3950.
40. Nabel, E. G. (1995) Gene therapy for vascular diseases. Atherosclerosis. 118, S51-S56.
41. 2-adrenergic receptors in large arteries. J. Mol. Cell. Cardiol. 30, 1037-1045.
42. Clowes, A. W., Reidy, M. A., and Clowes, M. M. (1983) Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab. Invest. 49, 327-337.
43. Takada, M., Tanaka, H., Yamada, T., Ito, O., Kogushi, M., Yanagimachi, M., Kawamura, T., Musha, T., Yoshida, F., Ito, M., Kobayashi, H., Yoshitake, S., and Saito, I. (1998) Antibody to thrombin receptor inhibits neointimal smooth muscle cell accumulation without causing inhibition of platelet aggregation or altering hemostatic parameters after angioplasty in rat. Circ. Res. 82, 980-987.
44. Burke, S. E., Lubbers, N. L., Gagne, G. D., Wessale, J. L., Dayton, B. D., Wegner, C. D., and Opgenorth, T. J. (1997) Selective antagonism of the ET(A) receptor reduces neointimal hyperplasia after balloon-induced vascular injury in pigs. J. Cardiovasc. Pharmacol. 30, 33-41.