Targeting Gβγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 7, 1999, Pages 3945-3950

  Iaccarino, Guido ^a   Smithwick, L Ashley ^a   Lefkowitz, Robert J ^a   Koch, Walter J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; PROTEIN SUBUNIT; BETA ADRENERGIC RECEPTOR KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYBRID PROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE TRANSFER; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; RESTENOSIS; REVASCULARIZATION; SERUM; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; ADENOVIRUS; ANIMAL; AORTA; BIOSYNTHESIS; CAROTID ARTERY; CAROTID ARTERY OBSTRUCTION; CELL CULTURE; CELL DIVISION; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; GENE THERAPY; GENETICS; GRAFT OCCLUSION; HYPERPLASIA; KINETICS; MACROMOLECULE; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PHYSIOLOGY;

ADENOVIRIDAE; ANGIOPLASTY, BALLOON; ANIMALS; AORTA; BETA-ADRENERGIC RECEPTOR KINASE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CAROTID ARTERIES; CAROTID STENOSIS; CELL DIVISION; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GRAFT OCCLUSION, VASCULAR; GTP-BINDING PROTEINS; HYPERPLASIA; KINETICS; MACROMOLECULAR SUBSTANCES; MUSCLE, SMOOTH, VASCULAR; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 0033616495     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.7.3945     Document Type: Article

References (35)

1. Gruentzig, A., Senning, A. & Siegenthaler, W. E. (1979) N. Engl. J. Med. 301, 61-68.
2. DeFeyter, P. J. & Serruys, P. W. (1994) in Textbook of Interventional Cardiology, ed. Topol E. J. (Saunders, Philadelphia), pp. 274-291.
3. Grines, C. L., Browne, K. F., Marco, J., Rothbaum, D., Stone, G. W., O'Keefe, J., Overlie, P., Donohue, B., Chelliah, N. & Timmis, G. C. (1993) N. Engl. J. Med. 328, 673-679.
4. McBride, W., Lange, R. A. & Hillis, L. D. (1988) N. Engl. J. Med. 318, 1734-1737.
5. Holmes, D. R., Jr., Vlietstra, R. E., Smith, H. C., Vetrovec, G. W., Kent, K. M., Cowley, M. J., Faxon, D. P., Gruentzig, A. R., Kelsey, S. F. & Detre, K. M. (1984) Am. J. Cardiol. 53, 77c-81c.
6. Indolfi, C., Awedimento, E. V., Rapacciuolo, A., Di Lorenzo, E., Esposito, G., Stabile, E., Feliciello, A., Melc, E., Giuliano, P., Condorelli, G. & Chiariello, M. (1995) Nat. Med. 1, 541-545.
7. van Biesen, T., Luttrell, L. M., Hawes, B. E. & Lefkowitz, R. J. (1996) Endocr. Rev. 17, 698-714.
8. Neer, E. J. (1995) Cell 80, 249-257.
9. Koch, W. J., Hawes, B. E., Allen, L. F. & Lefkowitz, R. J. (1994) Proc. Natl. Acad. Sci. USA 91, 12706-12710.
10. Pitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. L., Casey, P. J., Kirn, C., Benovic, J. L., Kwatra, M. M., Caron, M. G. & Lefkowitz, R. J. (1992) Science 257, 1264-1267.
11. Koch, W. J., Inglese, J., Stone, W. C. & Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 8256-8260.
12. Koch. W. J., Hawes, B. E., Inglese, J., Luttrell, L. M. & Lefkowitz, R. J. (1994) J Biol. Chem. 269, 6193-6197.
13. Nair, L. A., Inglese, J., Stoffel, R., Koch, W. J., Lefkowitz, R. J., Kwatra, M. M. & Grant, A. O. (1995) Circ. Res. 76, 832-838.
14. Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R. A., Bond, R. A., Milano, C. A. & Lefkowitz, R. J. (1995) Science 268, 1350-1353.
15. Clowes, A. W., Reidy, M. A. & Clowes, N. M. (1983) Lab Invest. 49, 327-337.
16. Chen, L. Q., Xin, X., Eckhart, A. D., Yang, N. & Faber, J. E. (1995) J. Biol. Chem. 270, 30980-30988.
17. Drazner, M. H., Peppel, K. C., Dyer, S., Grant, A. O., Koch, W. J. & Lefkowitz, R. J. (1997) J. Clin. Invest. 99, 288-296.
18. Akhter, S. A., Skaer, C. A., Kypson, A. P., McDonald, P. H., Peppel, K. C., Glower, D. D., Lefkowitz, R. J. & Koch, W. J. (1997) Proc. Natl. Acad. Sci. USA 94, 12100-12105.
19. Gaballa, M. A., Peppel, K., Lefkowitz, R. J., Aguirre, M., Dolber, P. C., Pennock, G. D., Koch W. J. & Goldman, S. (1998) J. Mol. Cell. Cardiol. 30, 1037-1045.
20. Luttrell, L. M., van Biesen, T., Hawes, B. E., Koch, W. J., Touhara, K. & Lefkowitz, R. J. (1995) J. Biol. Chem. 270, 16495-16498.
21. Chomczynski, P. & Sacchi, N. (1987) Anal. Biochem. 161, 156-159.
22. Xiao, R. P., Tomhave, E. D., Wang, D. J., Ji, X., Boluyt, M. O., Cheng, H., Lakatta, E. G. & Koch, W. J. (1998) J. Clin. Invest. 101, 1273-1282.
23. Jalink, K., Hordijk, P. L. & Moolenar, W. H. (1994) Biochim. Biophys. Acta. 98, 185-196.
24. Isner, J. M. & Feldman, L. J. (1994) Lancet 344, 1653-1654
25. Clapham, D. E. & Neer, E. J. (1997) Annu. Rev. Pharmacol. Toxicol. 37, 167-203.
26. Feldman, L. J., Pastore, C. J., Aubailly, N., Kearney, M., Chen. D., Perricaudet, M., Steg, P. G. & Isner, J. M. (1997) Gene Therapy 4, 189-198.
27. Paris, S. & Pouyssegur, J. (1986) EMBO. J. 5, 55-60.
28. Daaka, Y., Luttrell, L. M. & Lefkowitz, R. J. (1997) Nature (London) 390, 88-91.
29. Hayashida, W., Horiuchi, M. & Dzau, V. J. (1996) J. Biol. Chem. 271, 21985-21992.
30. Sachinidis, A., Seewald, S., Epping, P., Seul, C., Ko, Y. & Vetter, H. (1997) Mol. Pharmacol. 52, 389-397.
31. Fujitani, Y. & Bertrand, C. (1997) Am. J. Physiol. 272, C1492-C1498.
32. Takada, M., Tanaka, H., Yamada, T., Ito, O., Kogushi, M., Yanagimachi, M., Kawamura, T., Musha, T., Yoshida, F., Ito, M., et al. (1998) Circ. Res. 82, 980-987.
33. Burke, S. E., Lubbers, N. L., Gagne, G. D., Wessale, J. L., Dayton, B. D., Wegner, C. D. & Opgenorth, T. J. (1997) J. Cardiovasc. Pharmacol. 30, 33-41.
34. Serruys, P. W., Rutsch, W., Heyndrickx, G. R., Danchin, N., Mast, E. G., Wijns, W., Rensing, B. J., Vos, J. & Stibbe, J. (1991) Circulation 84, 1568-1580.
35. The MERCATOR Study Group (1992) Circulation 86, 100-110.