Factor H is a dermatan sulfate-binding protein: Identification of a dermatan sulfate-mediated protease that cleaves factor H

Journal of Biochemistry

Volumn 137, Issue 2, 2005, Pages 225-233

  Saito, Akio ^a   Munakata, Hiroshi ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Complement protein; Dermatan sulfate column; Human plasma; Proteolysis

Indexed keywords

(4 AMIDINOPHENYL)METHANESULFONYL FLUORIDE; AMIDASE; COMPLEMENT FACTOR H; DERMATAN SULFATE; DERMATAN SULFATE BINDING PROTEIN; EDETIC ACID; METHANESULFONYL FLUORIDE; N ETHYLMALEIMIDE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CHEMICAL BOND; ENZYME ACTIVITY; ENZYME INHIBITION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; WESTERN BLOTTING;

AMIDOHYDROLASES; COMPLEMENT FACTOR H; DERMATAN SULFATE; HUMANS; PHENYLMETHYLSULFONYL FLUORIDE; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS;

EID: 17044431125     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvi025     Document Type: Article

References (41)

1. Kjellén, L. and Lindahl, U. (1991) Proteoglycans: structures and interactions. Annu. Rev. Biochem. 60, 443-475
2. Iozzo, R.V. and Murdoch, A.D. (1996) Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function FASEB J. 10, 598-614
3. Iozzo, R.V. (1998) Matrix proteoglycans: from molecular design to cellular function. Annu. Rev. Biochem. 67, 609-652
4. Conrad, H.E. (1989) Structure of heparan sulfate and dermatan sulfate. Ann. N. Y. Acad. Sci. 556, 18-28
5. Jackson, R.L., Busch, S.J., and Cardin, A.D. (1991) Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes. Physiol. Rev. 71, 481-539
6. Hardingham, T.E. and Fosang, A.J. (1992) Proteoglycans: many forms and many functions. FASEB J. 6, 861-870
7. Lindahl, U., K-Gullberg, M., and Kjelléns, L. (1998). Regulated diversity of heparan sulfate. J. Biol. Chem. 273, 24979-24982
8. Bandtlow, C.E. and Zimmermann, D.R. (2000) Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol. Rev. 80, 1267-1290
9. Lander, A.D. (1994) Targeting the glycosaminoglycan-binding sites on proteins. Chem. Biol. 1, 73-78
10. Hileman, R.E., Fromm, J.R., Weiler, J.M., and Linhardt, R.J. (1998) Glycoaminoglycan-protein interactions: definition of consensus sites in glycosaminoglycan binding proteins. Bioessays 20, 156-167
11. Trowbridge, J.M. and Gallo, R.L. (2002) Dermatan sulfate: new functions from an old glycosaminoglycan. Glycobiology 12, 117R-125R
12. Tollefsen, D.M., Pestka, C.A., and Monafo, W.J. (1983) Activation of heparin cofactor II by dermatan sulfate. J. Biol. Chem. 258, 6713-6716
13. Ragg, H., Ulshofer, T., and Gerewitz, J. (1990) On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans. J. Biol. Chem. 265, 5211-5218
14. 2-terminal region of apolipoprotein B is sufficient for lipoprotein association with glycosaminoglycans. J. Biol. Chem. 273, 35355-35361
15. Camejo, G., Hurt-Camejo, E., Wiklund, O., and Bondjers, G. (1998) Association of apo B lipoproteins with arterial proteoglycans: pathological significance and molecular basis. Atherosclerosis 139, 205-222
16. Shuvaev, V.V., Laffont, I., and Siest, G. (1999) Kinetics of apolipoprotein E isoforms-binding to the major glycosaminoglycans of the extracellular matrix. FEBS Lett. 459, 353-357
17. Myles, T., Church, F.C., Whinna, H.C., Monard, D., and Stone, S.R. (1998) Role of thrombin anion-binding exosite-1 in the formation of thrombin-serpin complexes. J. Biol. Chem. 273, 31203-31208
18. Shirk, R.A., Parthasarathy, N., San Antonio, J.D., Church, F.C., and Wagner, W.D. (2000) Altered dermatan sulfate structure and reduced heparin cofactor II-stimulating activity of biglycan and decorin from human atherosclerotic plaque. J. Biol. Chem. 275, 18085-18092
19. Ripoche, J., Day, A.J., Harris, T.J.R., and Sim, R.B. (1988) The complete amino acid sequence of human complement factor H. Biochem. J. 249, 593-602
20. Zipfel, P.F., Jokiranta, T.S., Hellwage, J., Koistinen, V., and Meri, S. (1999) The factor H protein family. Immunopharmacology 42, 53-60
21. Pangburn, M.K., Atkinson, M.A.L., and Meri, S. (1991) Localization of the heparin-binding site on complement factor H. J. Biol. Chem. 266, 16847-16853
22. Blackmore, T.K., Sadlon, T.A., Ward, H.M., Lublin, D.M., and Gordon, D.L. (1996) Identification of a heparin binding domain in the seventh short consensus repeat of complement factor H. J. Immunol. 157, 5422-5427
23. Blackmore, T.K., Hellwage, J., Sadlon, T.A., Higgs, N., Zipfel, P.F., Ward, H.M., and Gordon, D.L. (1998) Identification of the second heparin-binding domain in human complement factor H. J. Immunol. 160, 3342-3348
24. Saito, A., Munakata, H., and Satoh, K. (2002) Glyco-western blotting: biotinylated dermatan sulfate as a probe for the detection of dermatan sulfate binding proteins using western blotting. Connect. Tissue Res. 43, 1-7
25. Gallimore, M.J. and Priberger, P. (1982) Simple chromogenic peptide substrate assays for determining prekallikrein, kallikrein inhibition and kallikrein "like" activity in human plasma. Thromb. Res. 25, 293-298
26. Skerka, C., Horstmann, R.D., and Zipfel, P.F. (1991) Molecular cloning of a human serum protein structurally related to complement factor H. J. Biol. Chem. 266, 12015-12020
27. Estaller, C., Koistinen, V., Schwaeble, W., Dierich, M.P., and Weiss, E.H. (1991) Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule. J. Immunol. 146, 3190-3196
28. Whaley, K. and Ruddy, S. (1976) Modulation of the alternative complement pathways by beta 1H globulin. J. Exp. Med. 144, 1147-1163
29. Deepa, S.S., Umehara, Y., Higashiyama, S., Itoh, N., and Sugahara, K. (2002) Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. J. Biol. Chem. 277, 43707-43716
30. Hellwage, J., Jokiranta, T.S., Koistinen, V., Vaarala, O., Meri, S., and Zipfel, P.F. (1999) Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin. FEBS Lett. 462, 345-352
31. Timmann, C., Leippe, M., and Horstmann, R.D. (1991) Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions. J. Immunol. 146, 1265-1270
32. Skerka, C., Timmann, C., Horstmann, R.D., and Zipfel, P.F. (1992) Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes. J. Immunol. 148, 3313-3318
33. Skerka, C., Kuhn, S., Gunther, K, Lingelbach, K., and Zipfel, P.F. (1993) A novel short consensus repeat-containing molecule is related to human complement factor H. J. Biol. Chem. 268, 2904-2908
34. Skerka, C., Hellwage, J., Weber, W., Tilkorn, A., Buch, F., Marti, T., Kampen, E., Beisiege, U., and Zipfel, P.F. (1997) The human factor H-related protein 4 (FHR-4). J. Biol. Chem. 272, 5627-5634
35. McRae, J.L., Cowan, P.J., Power, D.A., Mitchelhill, K.I., Kemp, B.E., Morgan, B.P., and Murphy, B.F. (2001) Human factor H-related protein 5 (FHR-5). J. Biol. Chem. 276, 6747-6754
36. Zipfel, P.E. and Skerka, C. (1994) Complement factor H and related proteins: an expanding family of complement-regulatory proteins? Immunol. Today 15, 121-126
37. Travis, J. and Salvesen, G.S. (1983) Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709
38. Hong, K., Kinoshita, T., Dohi, Y., and Inoue, K. (1982) Effect of trypsinization on the activity of human factor H. J. Immunol. 129, 647-652
39. Alsenz, J., Lambris, J.D., Schulz, T.F., and Dierich, M.P. (1984) Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38 kDa tryptic fragment of factor H. Biochem. J. 224, 389-398
40. Koistinen, V. (1992) Limited tryptic cleavage of complement factor H abrogates recognition of sialic acid-containing surfaces by the alternative pathway of complement. Biochem. J. 283, 317-319
41. Okada, K., Fukao, H., Tanaka, H., Ueshima, S., and Matsuo, O. (1990) Purification and characterization of a plasma factor which cleaves single-chain form of t-PA and u-PA. Thromb. Res. Suppl. 10, 27-43